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Method for preparing capsaicin microcapsule

A technology for capsaicin and microcapsules, which is applied in the field of preparing capsaicin microcapsules, can solve the problems of low drug loading and encapsulation efficiency, low capsule wall strength, and complicated operation, and achieves high drug loading and encapsulation efficiency. Improve the use environment and overcome the effect of cumbersome operation

Inactive Publication Date: 2008-04-30
SHANGHAI CHEM REAGENT RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the invention: to provide a preparation method of capsaicin microcapsules to overcome the shortcomings of the preparation methods in the prior art, such as cumbersome operation, low drug loading and encapsulation efficiency, and low capsule wall strength

Method used

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  • Method for preparing capsaicin microcapsule

Examples

Experimental program
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Effect test

Embodiment 1

[0023] (1) Preparation of melamine-formaldehyde resin prepolymer

[0024] Add 189.2g (1.5mol) melamine solids and 243.2g (3.0mol) 37wt% aqueous formaldehyde solution into a 500ml reaction flask equipped with a heater, stirrer and thermometer, and adjust the pH to 8 with 10wt% aqueous sodium hydroxide solution while stirring. Heat up and react at 70±5°C for 1.5 hours. Finally, add 300ml of water to dilute at room temperature to prepare 740.6g of melamine-formaldehyde resin prepolymer.

[0025] (2) Preparation of capsaicin emulsion

[0026] Weigh 50g capsaicin and dissolve it in 100ml ethyl acetate, respectively weigh 2.0g gum arabic powder, 2.0g Tween-80, 0.5g sodium polyacrylate, 1.0g polyvinyl alcohol and dissolve in 110ml water, and mix the two phases. Emulsify with FA25-18G high-shear dispersing emulsifier (produced by Shanghai FLUKO Fluid Machinery Manufacturing Co., Ltd.) at room temperature for 40 minutes to obtain 246.0 g of capsaicin emulsion.

[0027] (3) Preparation of c...

Embodiment 2

[0030] (1) Preparation of melamine-formaldehyde resin prepolymer

[0031] Add 126.1g (1.0mol) melamine solid and 150g (2.0mol) 25% formaldehyde aqueous solution into a 500ml reaction flask with heater, stirrer and thermometer, adjust the pH to 8 with 10% sodium hydroxide aqueous solution while stirring, and heat Increase the temperature and react at 70±5°C for 1.5 hours. Finally, 200ml of water was added to dilute at room temperature to prepare 479.0g of melamine-formaldehyde resin prepolymer.

[0032] (2) Preparation of capsaicin emulsion

[0033] Weigh 50g capsaicin and dissolve it in 100ml ethyl acetate, respectively weigh 2.0g gum arabic powder, 2.0g Tween-80, 0.5g styrene-maleic anhydride copolymer (SMA), 1.0g polyvinyl alcohol to dissolve The two phases were mixed in 120 ml of water and emulsified with a high-shear emulsifier (FA25-18G) at room temperature for 30 minutes to obtain 255.6 g of capsaicin emulsion.

[0034] (3) Preparation of capsaicin microcapsules

[0035] The...

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Abstract

The invention discloses a method for preparing capsaicin microcapsules. The method of the present invention uses melamine as a raw material, reacts with formaldehyde aqueous solution under alkaline conditions to obtain a melamine-formaldehyde resin prepolymer; emulsifies an organic solution of capsaicin and an emulsifier composed of a surfactant to obtain a capsaicin emulsion; and then Using melamine-formaldehyde resin prepolymer as wall material and capsaicin emulsion as core material, capsaicin microcapsules were prepared by in-situ polymerization under acidic conditions. The yield of the capsaicin microcapsules obtained by the preparation method of the invention is greater than 86.9-90.2%, the drug loading capacity is 18.4-24.7%, and the encapsulation rate is 88.5-94.3%. Compared with the prior art, the capsaicin microcapsules obtained by the preparation method of the present invention mainly have the following advantages: avoiding the strong irritation generated during use, greatly improving the use environment, meeting the requirements of green environmental protection, and the reaction process is safe and convenient. The drug dosage and encapsulation rate are high, and it is suitable for industrial production.

Description

Technical field [0001] The invention relates to a method for preparing capsaicin microcapsules. Background technique [0002] The main component of capsaicin is N-vanillylnonamide, which is widely used in antifouling coatings for ships to prevent and control post-harvest diseases of fruits and vegetables, and protect wires, cables, communication equipment, and packaging materials from being bitten by rats by taking advantage of its special pungent and spicy taste. Damaged, the grain is lost by bird food. The structural formula of capsaicin is as follows: [0003] [0004] In order not to change the original properties of capsaicin and to facilitate its use, microcapsules are often used for coating. The principle of the microcapsule method is to use the monomer and small molecules to undergo polymerization to form a polymer film-forming material. The capsule core encloses the material to be coated in microcapsules of several micrometers to hundreds of micrometers. The commonly u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/55B01J13/02
Inventor 何扣宝施险峰
Owner SHANGHAI CHEM REAGENT RES INST
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