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Application of 1,3-2-O-gallnut acyl 1-4,6-(S)-HHDP-beta-D-glucopyranose in preparing antineoplastic medicament

A kind of technology of galloyl group and glucopyranose, applied in the field of medicine

Inactive Publication Date: 2008-04-02
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Caffeoyl, Coumaroyl, Galoyl, and Hexahydroxydiphenoyl Glucoses from Balanophora japonica. Zhi-Hong JIANG, YokoHIROSE, et. Chem. Pharm. Bull. 49(7) 887-892 (2001) Chem.), no pharmacology of these compounds Activities, uses, pharmaceuticals and other reports

Method used

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  • Application of 1,3-2-O-gallnut acyl 1-4,6-(S)-HHDP-beta-D-glucopyranose in preparing antineoplastic medicament

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0141] 【prescription】

[0142] 1,3-Di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose 20g

[0143] Microcrystalline Cellulose 48g

[0144] Soluble starch 30g

[0145] Talc powder 2g

[0146] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0147] 【Preparation】

[0148] Weigh 20g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talcum powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0149] 【Dosage】

[0150] 2-3 tablets each time, 3 times a day.

[0151] 【For people】

[0152] Applicable to various tumor patients.

example 2

[0154] 【prescription】

[0155] 1,3-Di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose 10g

[0156] Microcrystalline Cellulose 48g

[0157] Soluble starch 40g

[0158] Talc powder 2g

[0159] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0160] 【Preparation】

[0161] Weigh 10g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talcum powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0162] 【Dosage】

[0163] 2-3 tablets each time, 3 times a day.

[0164] 【For people】

[0165] Applicable to various tumor patients.

example 3

[0167] 【prescription】

[0168] 1,3-Di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose 5g

[0169] Microcrystalline Cellulose 48g

[0170] Soluble starch 45g

[0171] Talc powder 2g

[0172] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0173] 【Preparation】

[0174] Weigh 5g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0175] 【Dosage】

[0176] 2-3 tablets each time, 3 times a day.

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Abstract

The invention provides the application method of 1,3-di-O-Galloyl-acyl 1-4,6-(S)-HHDP-Beta-D-glucoseglucopyranose in preparing tumor antitumor drugs, in particular the application of glucoseglucopyranose in preparing inducing agent to inhibit the growth of tumor cells and to accelerate tumor cell apoptosis. The invention also provides a tumor antitumor drug, which contains 5 to 20 percent of 1,3-di-O-Galloyl-acyl 1-4,6-(S)-HHDP-Beta-D-glucoseglucopyranose.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of 1,3-di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose. Background technique [0002] 1,3-Di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose is obtained from the aerial part of Balanophora japonica Makino, a plant of the family Balanophoraceae. A compound isolated from the methanol extract, its chemical formula is as shown in formula I. The compound is a yellow non-crystalline powder. (Caffeoyl, Coumaroyl, Galoyl, and Hexahydroxydiphenoyl Glucoses from Balanophora japonica. Zhi-Hong JIANG, YokoHIROSE, et. Chem. Pharm. Bull. 49 (7) 887-892 (2001) Chem.), no pharmacology of these compounds Activities, uses, pharmaceuticals and other reports. [0003] Contents of the invention [0004] The purpose of the present invention is to provide a new application of 1,3-di-O-galloyl 1-4,6-(S)-HHDP-β-D-glucopyranose in pharmacy. [0005] Actually, the present invention relates to ...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P35/00
Inventor 文晓芸吴少瑜姜志宏刘中秋张嘉杰饶进军王广发徐伟吕琳吴曙光
Owner SOUTHERN MEDICAL UNIVERSITY
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