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Oligomeric glucose sulfuric ester and preparation thereof

A technology of oligoglucose and sulfuric acid ester, which is applied in the field of sugar derivative production to achieve the effect of abundant raw material sources and simple process

Inactive Publication Date: 2008-03-26
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And for utilizing the cellulose that exists in a large amount in nature, starch to prepare the research of oligoglucosulphate has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation method of oligoglucose sulfate

[0020] Measure 800ml of concentrated sulfuric acid (98%) into a beaker, place the beaker in a low-temperature thermostat at -5°C, and add 600ml of n-propanol. Weigh 40 g of dry cotton and add it to the above-mentioned prepared reaction solution, keep the temperature at 0°C, and react for 5 hours. Remove the reaction solution by suction filtration with a sand core funnel, and wash with 5 L of propanol until the washing solution no longer shows acidity. Dissolve the residue after suction filtration in 2L of water, keep the temperature at 60°C, and stir to make it uniform. Suction filtration at room temperature, the filtrate is glucose sulfate aqueous solution, 10 times the volume of ethanol is added to the above aqueous solution, and the resulting solution is centrifuged in a high-speed centrifuge at 3000rpm for 10 minutes to obtain oligoglucose sulfate precipitate. After precipitation, drying and pulverizat...

Embodiment 2

[0021] Embodiment 2: the preparation method of oligoglucose potassium sulfate

[0022] Measure 800ml of concentrated sulfuric acid (98%) into a beaker, place the beaker in a low-temperature thermostat at -5°C, and add 600ml of n-propanol. Weigh 40 g of dry cotton and add it to the above-mentioned prepared reaction solution, keep the temperature at 0°C, and react for 5 hours. Remove the reaction solution by suction filtration with a sand core funnel, and wash with 5 L of propanol until the washing solution no longer shows acidity. Dissolve the residue after suction filtration in 2L of water, keep the temperature at 60°C, stir to make it uniform, and at the same time add KOH solution dropwise to adjust its pH to 9, and stir for 2 hours. Suction filtration at room temperature, the filtrate is glucose sodium sulfate aqueous solution, 10 times the volume of ethanol is added to the above aqueous solution, and the resulting solution is centrifuged in a high-speed centrifuge at 3000 ...

Embodiment 3

[0023] Embodiment 3: the preparation method of oligoglucose potassium sulfate

[0024] Measure 800ml of concentrated sulfuric acid (98%) into a beaker, place the beaker in a low-temperature thermostat at -5°C, and add 400ml of n-propanol. Weigh 40g of dry cotton and add it to the above-mentioned prepared reaction solution, keep the temperature at 0°C, and react for 10h. Remove the reaction solution by suction filtration with a sand core funnel, and wash with 5 L of propanol until the washing solution no longer shows acidity. Dissolve the residue after suction filtration in 2L of water, keep the temperature at 90°C, stir to make it uniform, and at the same time add KOH solution dropwise, adjust its pH to 9, and stir for 4h. Suction filtration at room temperature, the filtrate is glucose sodium sulfate aqueous solution, 50 times the volume of ethanol is added to the above aqueous solution, and the resulting solution is centrifuged in a high-speed centrifuge at 3000 rpm for 15 m...

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Abstract

The present invention discloses one kind of oligoglucose sulfate and its preparation process. The oligoglucose sulfate with relatively great molecular weight is obtained through simultaneous esterification and decomposition in organic solvent dispersed concentrated sulfuric acid, and may be further hydrolyzed or enzymolyzed to reduce its molecular weight. The oligoglucose sulfate prepared with cellulose and starch as material has controllable structure, and adjustable molecular weight and sulfate radical substitution degree. It possesses immune regulating effect and anticancer activity, simple preparation process and rich material source.

Description

technical field [0001] The present invention relates to the production of carbohydrate derivatives, in particular to sulfated derivatives of oligoglucose and its preparation method. Background technique [0002] Polysaccharide sulfate (polysaccharides sulfated, PSS) refers to natural and semi-synthetic acidic polysaccharides containing sulfate groups, a type of chemical structure formed by replacing some hydroxyl groups on monosaccharide molecules in polysaccharide macromolecular chains with sulfate groups Complex polysaccharide derivatives with diverse biological activities and clear structure-activity relationships. The preparation of sulfated polysaccharides includes two ways of separation and purification from natural raw materials and artificial synthesis. Natural polysaccharide sulfates are mainly extracted from land and marine animal and plant tissues and microorganisms, mainly including heparin, chondroitin, fucoidan sulfate, and sulfated galactan; artificially synt...

Claims

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Application Information

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IPC IPC(8): C08B37/02
Inventor 陈国
Owner HUAQIAO UNIVERSITY
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