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Carmustine intravenous emulsion and its preparation method

A carmustine and intravenous infusion technology, which is applied in the field of carmustine intravenous emulsion and its preparation, can solve the problems of difficulty in popularization and instability, and achieve the effects of improving stability and reducing toxic and side effects

Inactive Publication Date: 2008-03-19
大道隆达(北京)医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The carmustine currently on the market is a small-volume injection. Although four manufacturers have production approval documents, only one produces it. Because the product is unstable at room temperature, and it needs to be transported in ice packs to keep it stable. Therefore, it is very difficult to promote

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 1.2 g of carmustine in 8 g of benzyl alcohol, and dissolve 12 g of egg yolk lecithin in 100 g of soybean oil (with 0.6 g of vitamin E added) heated to 80° C. to obtain an oil phase. Under high-speed stirring, Slowly inject the above-mentioned oil phase into water for injection (about 800ml) that has 22.5g glycerin added, and stir under the condition of 7000rpm for 30min to obtain colostrum, set the volume to 1000ml, transfer to a homogenizer for homogenization, then filter, potting and Sterilize and serve.

Embodiment 2

[0022] Dissolve 1.2g of carmustine in 8g of benzyl alcohol, and dissolve in 100g of soybean oil (with 0.6g of vitamin E added) heated to 80°C to obtain an oil phase. Inject water for injection (about 800ml) with 22.5g glycerin and 12g egg yolk lecithin, stir at 7000rpm for 30min to obtain colostrum, set the volume to 1000ml, transfer to a homogenizer for homogenization, and then filter, pot and sterilize. Get the bacteria.

Embodiment 2

[0024] Dissolve 1.2 g of carmustine in 8 g of benzyl alcohol, and dissolve 12 g of egg yolk lecithin in 100 g of soybean oil heated to 80°C (with 0.6 g of vitamin E and 0.3 g of oleic acid added) to obtain an oil phase. Under high-speed stirring conditions, slowly inject the above oil phase into water for injection (about 800ml) added with 22.5g glycerin, stir at 7000rpm for 30min to obtain colostrum, set the volume to 1000ml, transfer to a homogenizer for homogenization, and then It is obtained by filtering, potting and sterilizing.

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Abstract

The invention relates to a carmustine combination, which is used for the vein transfusion and is in a stable oil-in-water emulsion. The invention also relates to the method of mixing the carmustine into the oil to form the stable oil-in-water emulsion. The combination includes the carmustine, the oil, the water and a surfactant.

Description

field of invention [0001] The invention relates to an intravenous emulsion of carmustine and a preparation method thereof, belonging to the field of medical science and technology. Background technique [0002] At present, the number of cancer patients in my country is about 1.6 million every year, and the number of people who die from cancer every year has risen from 700,000 to 1.3 million. Cancer treatment has become one of the key points of my country's health strategy. With the rising incidence of cancer, the world's anticancer drug market has grown rapidly. In 1999, the global sales of anticancer drugs were about 23.8 billion US dollars. There are about several hundred kinds of anticancer drugs in the world, and about 80 kinds of anticancer drugs are commonly used. Among them, the use of alkylating agents to treat malignant tumors has a history of more than 30 years. Due to their very active drug properties, they can undergo alkylation reactions on the nucleophilic gro...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/17A61P35/00
Inventor 周英
Owner 大道隆达(北京)医药科技发展有限公司
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