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Method for extracting codonopsis pilosula polyoses

A technology of Codonopsis polysaccharide and extraction method, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of unreasonable selection of technical parameters, low content of Codonopsis polysaccharides, and many impurities in extracts, and achieves enhanced The effect of bone marrow hematopoietic function, good appearance and simple steps

Inactive Publication Date: 2008-02-27
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims to solve the unreasonable selection of technical parameters of the existing Codonopsis polysaccharide extraction method, the content of Codonopsis polysaccharide in the extract is relatively low, the extraction process has not examined the extraction rate and has not been purified, the extract has many impurities, poor appearance and properties, and the polysaccharide components are not clear. etc., providing a method for extracting Codonopsis polysaccharides

Method used

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  • Method for extracting codonopsis pilosula polyoses
  • Method for extracting codonopsis pilosula polyoses
  • Method for extracting codonopsis pilosula polyoses

Examples

Experimental program
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Effect test

Embodiment 1

[0018] The extraction method of Codonopsis polysaccharides includes the following steps: (1) dust removal and cleaning: 100 g of medicinal material Codonopsis pilosula is rinsed with clean water; (2) chopping: cutting Codonopsis pilosula into 2-4 cm sections; (3) Impurity removal: chopping Dangshen section, reflux 80% ethanol for 2 times, each time for 1 hour, and evaporate the ethanol; (4) water extraction: add distilled water with 8 times the weight of the drug residue to the dregs after removal of impurities, and reflux with boiling water for 2 times, each time for 1 hour, Filtrate, combine the filtrates, concentrate under reduced pressure until the relative density of the medicinal solution is 0.8g / ml, and place to cool; (5) ethanol precipitation: add ethanol to the concentrated solution that has been left to cool until the concentration of alcohol precipitation is 70%, let stand, and centrifuge to obtain Alcohol precipitation; (6) Dehydration: Wash the alcohol precipitatio...

Embodiment 2

[0023] The extraction method of Codonopsis polysaccharides includes the following steps: (1) dust removal and cleaning: 100 g of medicinal material Codonopsis pilosula is rinsed with clean water; (2) chopping: cutting Codonopsis pilosula into 2-4 cm sections; (3) Impurity removal: chopping Dangshen section, reflux 3 times with 95% ethanol, 2 hours each time, evaporate the ethanol; (4) water extraction: add distilled water with 20 times the weight of the dregs of the drug dregs after impurity removal, reflux 2 times with boiling water, 2 hours each time, Filtrate, combine the filtrates, concentrate under reduced pressure until the relative density of the medicinal solution is 1.2g / ml, and place to cool; (5) ethanol precipitation: add ethanol to the concentrated solution that has been left to cool until the alcohol precipitation concentration is 90%, leave it still, and centrifuge to obtain Alcohol precipitation; (6) Dehydration: Wash the alcohol precipitation with absolute ethan...

Embodiment 3

[0028] The extraction method of Codonopsis polysaccharides includes the following steps: (1) dust removal and cleaning: 300 g of medicinal material Codonopsis pilosula is rinsed with water; (2) chopping: cutting Codonopsis pilosula into 2-4 cm sections; (3) Impurity removal: chopping Dangshen section, reflux 3 times with 90% (or 85% ethanol) ethanol, each time for 1.5 hours, and evaporate the ethanol; (4) water extraction: add 15 times (or 10 times or 13 times or 18 times) the dregs after removing impurities ) distilled water with the weight of dregs, boiling water reflux extraction 3 times, each time for 1.5 hours, filter, combine the filtrate, concentrate under reduced pressure until the relative density of the medicinal liquid is 1.0g / ml, place to cool; (5) ethanol precipitation: place the cooled Add ethanol to the concentrated solution until the alcohol precipitation concentration is 80% (or 75% or 85%), let it stand, and centrifuge to obtain the alcohol precipitation; (6) ...

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Abstract

The invention discloses an extracting method of codonopsis pilosula polysaccharide, which comprises the following steps: dedusting; cleaning; cutting; removing impurity; refluxing the codonopsis pilosula segment through 80-95% alcohol; doing aqueous extraction; decompressing; condensing until the relative density of drug liquid is 0. 8-1. 2g / ml; placing; cooling; sedimenting through alcohol; adding alcohol into the placed and cooled condensate until the alcohol density is 70-90%; stewing; centrifuging; obtaining the alcohol sediment; dehydrating; drying; obtaining the product with content of the codonopsis pilosula polysaccharide over 70% and extracting rate at 20-30%. The invention simplifies the operation with low cost, which reduces the impurity to possess good appearance, therefore adding the subsequent purifying disposal to clarify the structural component.

Description

technical field [0001] The invention relates to a method for extracting effective components of Chinese medicinal materials, in particular to a method for extracting Codonopsis polysaccharides. Background technique [0002] Codonopsis (Radix Codonopsis) is a plant belonging to Codonopsis of Campanulaceae. The dried root is used as medicine to invigorate the middle and Qi, strengthen the spleen and lungs. For weakness of the spleen and lung, shortness of breath and palpitations, lack of appetite and loose stools, cough due to deficiency, and cough due to internal heat. [0003] Codonopsis pilosula mainly contains (1) sugars, polysaccharides and heteropolysaccharides, of which 4 heteropolysaccharides CPI-IV have been identified, mainly composed of glucose, fructose, galactose, mannose, arabinose, xylose and rhamnose Composed in different proportions. In addition, it contains more inulin and fructose. (2) Glycosides, syringin n-hexyl-β-D-glucopyranoside, ethyl-α-D-fructofura...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61P1/14A61P11/06A61P11/14C08B37/00A61K125/00
Inventor 高建平李瑞燕郑庆红漆小梅张志勇
Owner SHANXI MEDICAL UNIV
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