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Medicament spraying agent used for accelerating growth of hair

A technology of hair growth and spray, which is applied in the field of medicine, can solve the problems of poor transdermal absorption, small curative effect of local lesions, toxic and side effects, etc., and achieve the effects of improving drug efficacy, good protection, and reducing irritation

Inactive Publication Date: 2008-02-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Liposome (liposome) hair disease treatment has always had the following two important problems: 1. the lesion is limited to the hair, and after systemic administration, it is transported, distributed and metabolized in the body. The ideal therapeutic concentration will inevitably cause systemic toxic and side effects; ② Some drugs have a good curative effect when administered systemically, but once they are administered locally, the curative effect on local lesions is very small or even ineffective due to poor transdermal absorption

Method used

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  • Medicament spraying agent used for accelerating growth of hair
  • Medicament spraying agent used for accelerating growth of hair
  • Medicament spraying agent used for accelerating growth of hair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: Contain 1.5% minoxidil in the drug liposome product

[0072] Drug liposome prescription:

[0073] name

[0074] Add the prescribed amount of lecithin and minoxidil to 40ml of ethanol, heat to 45°C and stir to dissolve completely. Then slowly add the ethanol drug solution into 60ml of pure water stirred at a high speed (3000r / min) by a shearing machine, and continue to stir for 30min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized by a high-pressure extruder for 7 times at a pressure of 4Mpa to 6MPa. During the homogenization process, the temperature should not exceed 60°C to obtain a large single-chamber single-phase liposome drug solution with a particle size of 200nm±50nm . The final product after dilution is a homogeneous milky solution without precipitation or stratification. After the product is filled, it should be stored at 2°C to 15°C and protected from li...

Embodiment 2

[0075] Embodiment 2: Contain 0.5% minoxidil in the drug liposome product

[0076] Drug liposome prescription:

[0077] name

molecular weight

The molar ratio of(%)

Feed amount (g)

Lecithin

760

80

8.36

Minoxidil

209.25

20

0.5

[0078] Get the prescribed amount of lecithin, minoxidil, add 24ml of ethanol, heat and stir until fully dissolved. Slowly add the ethanol drug solution to 76ml of pure water stirred at high speed (3000r / min) by a shearing machine, and continue to stir for 35min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized by a high-pressure extruder for 6 times at a pressure of 4-6MPa. During the homogenization process, the temperature should not exceed 60°C to obtain a large single-chamber single-phase liposome drug with a particle size of 200nm±35nm solution. The final product is a homogeneous milky solutio...

Embodiment 3

[0112] Embodiment 3: Contain 1% minoxidil in the drug liposome product

[0113] Drug liposome prescription:

[0114] name

[0115] Add 24ml of ethanol to the prescribed amount of lecithin, minoxidil, azone, vitamin E, and peppermint oil, heat and stir until completely dissolved. Slowly add the ethanol drug solution to 76ml of pure water stirred at high speed (3000r / min) by a shearing machine, and continue to stir for 35min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized by a high-pressure extruder for 6 times at a pressure of 4-6MPa. During the homogenization process, the temperature should not exceed 60°C to obtain a large single-chamber single-phase liposome drug with a particle size of 200nm±35nm solution. The final product is a homogeneous milky solution without precipitation or stratification. After the product is filled, it should be stored at 2°C to 15°C and protected from ligh...

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Abstract

The invention discloses a drug spray to accelerate the growth of hair, which comprises the following parts: minuodier, lecithine, vitamin E, natural essential oil and alcohol, wherein all or part of the components can be applied to prepare spray agent with alcohol liposome minuodier, which is covered by liposome to solve the solubility of minuodier and uniformity of drug in the water to strengthen the percutaneous absorption and drug effect after transmitting the drug into derma. The invention avoids side effect to reduce the toxicity for blood circulating system and stimulation for skin, which protects skin effectively.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medicine spray preparation, in particular to a medicine spray for promoting hair growth. Background technique [0002] Hair loss is a common clinical and frequently-occurring disease. Although it is not life-threatening, it has a great impact on patients' social interaction and mental health. Most of the products on the market today are ineffective, as evidenced by the fact that the FDA has only certified two treatments for hair loss [1] . At present, hair tissue engineering and hairy skin tissue engineering have not been completely successful, and there are still many difficulties. Therefore, aiming at the difficult hair regeneration in skin beauty, it is of great significance to develop highly effective, specific and small side effect drugs for the treatment of hair loss. [0003] Minoxidil (minoxidil) Minoxidil [2] It is a pyrimidine derivative (2,4-diamino-3-hydroxy-6-piperidine py...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K9/12A61K9/127A61K47/22A61K47/24A61P17/14
Inventor 杨壮群屠军波薛瑛宋勇陈涛傅经国
Owner XI AN JIAOTONG UNIV
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