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Pharmaceutical composition containing triacetyl andrographolidume and medical use of the same

A technology of andrographolide and triacetyl, used in immunosuppressive and anti-tumor drugs, in the field of preparation of anti-inflammatory

Inactive Publication Date: 2008-02-27
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, the pharmacological activity of triacetylandrographolide has not been reported yet, the inventor has conducted in-depth research on this, and in vivo experiments have shown that triacetylandrographolide has anti-inflammatory, immunosuppressive and anti-tumor purposes

Method used

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  • Pharmaceutical composition containing triacetyl andrographolidume and medical use of the same

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Experimental program
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Embodiment Construction

[0006] 1. Preparation of triacetylandrographolide

[0007]

[0008] Add 5g (14.3mmol) of andrographolide (1), 20mL of acetic anhydride, and 2g of newly molten zinc chloride into a 100mL single-necked flask in sequence, attach a reflux condenser, and heat in an oil bath at 80°C. After the reaction solution was clarified, the reaction was stopped, and the reaction solution was poured into a beaker filled with 80 mL of ice water, stirred vigorously, filtered with suction, and the filter cake was washed with water to pH7. The filter cake was crystallized with ethanol to obtain 4.7 g of white needle crystals with a yield of 67.8%. m.p.128°C. IR (cm -1 ): 2976, 2955, 2925, 2868, 1753, 1736, 1680, 1450, 1375, 1251, 1026, 908. MS (ESI) m / z: 476.3M + , 477.3(M+1) + , 499.3 (M+Na) + . 1 H-NMR (CDCl 3 , δ): 7.01 (1H, t, J=5.2, 12-H), 5.91 (1H, d, J=6.0, 14-H), 4.90, 4.53, (each 1H, s, 17-H), 4.60 (1H, dd, J=6.1, 11.2, 15-H), 4.55 (1H, dd, J=5.0, 11.2, 15-H), 4.38, 4.14 (each ...

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Abstract

The invention discloses an application of triacetyl andrographolide to prepare antiphlogistic, immune inhibition and antineoplastic drug, which can be drug composition of medically acceptable carrier as active component.

Description

technical field [0001] The invention relates to the use of triacetylandrographolide in the preparation of anti-inflammatory, immunosuppressive and anti-tumor drugs. The present invention further relates to a pharmaceutical composition containing triacetylandrographolide as an active ingredient and a pharmaceutically acceptable carrier, and its use in the preparation of anti-inflammatory, immunosuppressive and anti-tumor drugs. Background technique [0002] Andrographis panniculata (Burm.f.) Nees is the dry aerial part of Andrographis panniculata (Burm.f.) Nees. Originally produced in India, it is cultivated in East China, Central South and Southwest my country. Bitter in the mouth, cold in nature, Guixin, lung, large intestine, bladder meridian. It has the effects of clearing heat and detoxifying, cooling blood and reducing swelling. It is used for cold and fever, sore throat, aphtha of the mouth and tongue, sudden cough and overworked cough, diarrhea and dysentery, astri...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P29/00A61P37/06C07D307/58
Inventor 韩光许启泰刘蕾谢松强杜钢军谭宏
Owner HENAN UNIVERSITY
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