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Konjak portuguese gansu polyose gel microsphere and method for preparing same

A technology of konjac glucomannan and gel microspheres, which is applied in the preparation of microspheres, microcapsule preparations, etc., can solve the problems of complex operation, strict requirements, and complex reaction equipment in the reaction process, and achieve simplified sphere-forming process steps, The effect of shortening the production cycle and expanding the separation range

Active Publication Date: 2008-01-30
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Japanese scholars [JP Zhao 62-236839, JP Ping 1-94949] once used konjac glucomannan to synthesize a chromatography medium, but the process route is lengthy, the production cycle is about five or six days, and a large amount of solvent is consumed. Not only expensive, but also difficult to industrial production
The Chengdu Branch of Chenguang Chemical Industry Research Institute of the Ministry of Chemical Industry [CN 1078724A] has developed a preparation method of bead-shaped cross-linked dextran that can be used as a gel filtration medium. Although this method can be used for industrial production, the reaction equipment of this method Complicated, the reaction process is complex and demanding, which is not conducive to large-scale industrial production, and the produced product is a gel-type structure. Only the gel medium containing chemical pores formed by cross-linking has been studied, resulting in biological macromolecules with a molecular weight greater than 100,000. Molecular separation is limited
With the in-depth study of konjac glucomannan as a gel medium, it is necessary to further improve and improve the previous process route, and develop a new series of konjac glucomannan products to overcome the shortcomings of the traditional preparation methods and the resulting Brings defects such as limited application

Method used

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  • Konjak portuguese gansu polyose gel microsphere and method for preparing same
  • Konjak portuguese gansu polyose gel microsphere and method for preparing same
  • Konjak portuguese gansu polyose gel microsphere and method for preparing same

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Experimental program
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Effect test

Embodiment 1

[0034] Preparation of aqueous solution of konjac glucomannan.

[0035] In a 1000ml reactor, mix 45.6ml of 0.5M HCl and 272.7g of water evenly, pour 56.7084g of commercially available konjac fine powder into the mixture, and stir evenly. Seal the reactor, put it in an autoclave, and degrade it at 113°C for 40 minutes. After the degradation is complete, take out the reactor. After the temperature drops to room temperature, pour 125g of 40% NaOH into it to dissolve it. Yellow 10% solid content konjac glucomannan aqueous solution. According to this method, an aqueous solution of konjac glucomannan with a solid content of 6% and 15% can be prepared for future use.

Embodiment 2

[0037] Preparation of konjac glucomannan gel microspheres in xylene system.

[0038] In a 250ml reactor with a stirring device, add 235ml of xylene mixed with 1.67g of ethyl cellulose and 0.83g of Span 60, heat up to 50°C, and add a 6% glucomannan aqueous solution under stirring 100g, dropwise add 50ml of cross-linking agent epichlorohydrin, dropwise for 2 hours. After the dropwise addition, the temperature was raised to 60° C. for 8 hours, and the microspheres solidified. The microspheres are filtered out, the dispersion medium is recovered, and the microspheres are washed repeatedly with a large amount of water. Light round microspheres with a particle size of 200-300um. The optical microscope photos of the gel microspheres are shown in Figure 2.

Embodiment 3

[0040] Preparation of Konjac Glucomannan Gel Microspheres in Liquid Paraffin System.

[0041]In a 250ml reactor with a stirring device, add 150ml of liquid paraffin mixed with 1.5g of Span 80, raise the temperature to 50°C, add 50g of glucomannan aqueous solution with a concentration of 6% under stirring, and add the crosslinking agent dropwise Add 25ml of epichlorohydrin dropwise for 1 hour. After the dropwise addition is completed, heat up to 60°C for 8 hours. The microspheres solidify, filter out the microspheres, and wash the microspheres repeatedly with a large amount of water to obtain a particle size of 120-200um. between the microspheres.

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Abstract

The invention discloses macroporous konjac glucomannan granules, specific surface area and pore volume of which are respectively 5-15m2 / g and 0.1-0.8 ml / g. The invention also discloses a preparation method of konjac glucomannan granules. Pore-foaming agent is added in konjac glucomannan aqueous solution; macroporous konjac glucomannan granules of different specifications and pore volumes can be prepared by adjusting the content of pore-foaming agent. The preparation method provided by the invention that adopts balling and crosslinking one step reaction shortens production period and simplifies balling process steps, which results in that only 5-12 hours and simple reaction device can produce; besides, the macroporous konjac glucomannan granules provided by the invention can be widely applied to the separation and the purification of the protein.

Description

technical field [0001] The present invention relates to a kind of konjac glucomannan gel microsphere, more specifically, the present invention relates to a kind of macroporous konjac glucomannan gel microsphere and the preparation method of konjac glucomannan gel microsphere . Background technique [0002] Konjac is a plant of the Araceae family Amorpho phallus konjac K.Koch as a corm. The main component is polysaccharides, which are polysaccharides linked by glucose and mannose through β1,4-glucosidic bonds, and the ratio of mannose to glucose in the molecular chain is 2:1. Dextran has been widely used as a natural polysaccharide chromatography medium. Konjac glucomannan is very similar to dextran in structure, and it has many characteristics of dextran as an ideal medium: high hydrophilicity, containing more The hydroxyl group is activated and non-specific adsorption does not occur with biomacromolecules, so the preparation of glucomannan gel microspheres can be applied ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/02B01J13/14
Inventor 马光辉苏志国王佳兴葛佳丽
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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