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Acid-alkaline buffering composition

An acid-base buffering and composition technology, applied in the directions of drug combination, drug delivery, pill delivery, etc., can solve the problems of lack of human experimental data, support and proof, and high requirements for preparation process.

Active Publication Date: 2010-05-12
BEIJING COMPETITOR SPORTS SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation process is very demanding, and there is no clear support and proof of human experimental data in terms of buffering body fluid pH, improving body acidity, improving exercise capacity and anti-fatigue

Method used

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  • Acid-alkaline buffering composition

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Experimental program
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Effect test

Embodiment 1

[0041] The ingredients are taken as follows (weight in g): sodium bicarbonate 100, sodium citrate 100, potassium hydrogen phosphate 100, calcium chloride 100, magnesium oxide 100, carnosine 1000, anserine 1000, glutamine 1000, stearic acid Magnesium 1000. The above ingredients are sieved (40 mesh), the impurities in the residue on the sieve are removed, and the large particles are pulverized with a pulverizer and then sieved. Then fully stir the material, pour it into the capsule filling mold, plan the powder on the surface of the capsule, pack it separately, add desiccant and cotton, then seal the electromagnetic induction film, screw the cap, and sterilize to obtain the acid-base buffer capsule of the present invention agent.

Embodiment 2

[0043] The ingredients are taken as follows (weight in g): 350,000 sodium bicarbonate, 50,000 sodium carbonate, 100 potassium dihydrogen phosphate, 650,000 carnosine hydrochloride, 820,000 anserine sulfate, 420,000 glutamine, 500,000 starch, 500,000 dextrin, Sucrose powder 4,000,000. The above ingredients are sieved (40 mesh), the impurities in the residue on the sieve are removed, and the large particles are pulverized with a pulverizer and then sieved. Then the materials are fully stirred, and 80% ethanol is used as a binder to obtain a suitable soft material, and the above soft material is granulated by a YK-160 swing granulator with a 12-mesh mesh to make wet granules. Divide the wet granules equally, and after the alcohol is completely volatilized, put the bulk material into the DPL-30 multifunctional granulator, and boil and dry at 50°C for about an hour, so that the moisture content of the final product is controlled within 5%. Afterwards, the granules are sized and pa...

Embodiment 3

[0045] The ingredients are taken as follows (weight in g): sodium bicarbonate 35000, magnesium citrate 100, potassium dihydrogen phosphate 9800, sodium chloride 100, carnosine tartrate 65000, anserine lactate 82000, glutamine 42000, starch 500000, dextrin 40000, sucrose powder 10000. The above ingredients are sieved (40 mesh), the impurities in the residue on the sieve are removed, and the large particles are pulverized with a pulverizer and then sieved. Add 5% HPMC and CMS-Na, mix the above materials, add an aqueous solution containing 30% ethanol and stir thoroughly to make a soft material. The above soft materials are granulated by a YK-160 oscillating granulator with 12 meshes to make wet granules. After the ethanol is completely volatilized, the bulk material is placed in a DPL-30 multifunctional granulator, and boiled and dried at 60°C to make dry granules. A small amount of magnesium stearate is added to the granules, and compressed into tablets with a tablet machine....

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Abstract

The invention provides an acid alkaline buffering compound, which takes basic salt, glutamine, karnosin and anserine as its main ingredients. The compound is able to balance the acid alkaline environment of body fluid, enhance the pH value of blood, alleviate the slowdown of motion capability due to the deposition of lactic acid, ease the fatigue of human body and improve the motion capability.

Description

technical field [0001] The invention relates to a buffer composition, in particular to an acid-base buffer composition for regulating physiological acid-base balance. Background technique [0002] A constant acid-base balance is one of the important conditions for maintaining the normal metabolism of cells. Although a normal human body often takes in or produces various acidic or alkaline products in the metabolic process, the plasma pH is constant in the range of 7.35 to 7.45. There are several mechanisms for maintaining a constant pH: one is to rely on the buffer system in the body to make the blood [H + ] Not only can it be kept at a very low concentration, but also quite constant; the second is to rely on the kidneys, on the one hand, the kidneys can maintain the total amount of buffered bases by regulating the reabsorption of bicarbonate, and on the other hand, they can achieve acid-base levels by excreting acids or bases In addition, the movement of ions inside and ou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/197A61K38/16A61K33/06A61K47/38A61K9/08A61K9/20A61K9/48A61P3/12
Inventor 杨则宜焦颖白厚增张云龙魏冰
Owner BEIJING COMPETITOR SPORTS SCI & TECH
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