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Method for preparation of fermentation cordyceps active site and the application thereof in the aspect of respiratory disease

A technology for fermenting Cordyceps fungus powder and active parts, applied in the field of medicine, can solve problems such as influence on clinical curative effect, interference, etc., and achieve the effects of easy control of active ingredient content, reduced dosage, and increased curative effect

Inactive Publication Date: 2008-01-02
王勤科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When Cordyceps is used for a specific disease such as chronic bronchitis, a large number of ineffective chemical components dissolved by it will interfere and affect its clinical efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0019] Preparation Example 1: CO Fermented Cordyceps Powder 2 Preparation of effective active parts or active components by supercritical extraction

[0020] Method 1: Put the fermented Cordyceps powder or Cordyceps cephalosporin powder into the extraction tank, extract at T: 60-70°C, P: 25-35Mpa for 60-90 minutes, and collect the initial extraction liquid. After the first extraction, the Cordyceps mycelium was incubated at 60-70°C for 6-24 hours, and then CO 2 Supercritical extraction was performed for 60-90 minutes, and the second extraction liquid was collected. The combined extracts are vacuum filtered and then concentrated under reduced pressure until the density is 1.1 to 1.3. 2 The supercritical extract is yellowish-brown pseudo-oil.

[0021] Method 2: Put the fermented Cordyceps powder or Cordyceps cephalosporin powder into the extraction cylinder, put it into a supercritical extraction kettle, the extraction temperature is 45°C, the extraction pressure is 20Mpa, an...

preparation example 2

[0021] Method 2: Put the fermented Cordyceps powder or Cordyceps cephalosporin powder into the extraction cylinder, put it into a supercritical extraction kettle, the extraction temperature is 45°C, the extraction pressure is 20Mpa, and after cyclic extraction, keep constant temperature and pressure for 2hrs to obtain supercritical extract. Preparation Example 2: Fat-soluble organic solvent extraction / extraction of fermented Cordyceps fungus powder to prepare its effective active parts or active components

[0022] Method 1: Beat the fermentation product produced by the fermented Cordyceps mycelia, that is, Paecilomyces strain Cs-4, into a coarse powder, add a certain amount of ethanol, and add diethyl ether or Petroleum ether was refluxed twice, each time for 1 hr, and the filtrates were filtered and combined to recover diethyl ether or petroleum ether, and dried under reduced pressure to remove residual solvents, and the effective active site was prepared as a brown oil.

...

preparation example 3

[0024] Method 3: Beat the mycelium of Cordyceps sinensis into a coarse powder, add 95% ethanol to reflux twice, the first time for 1.5 hours, the second time for 1 hour, filter respectively, combine the filtrates, and concentrate under reduced pressure to form a liquid extract. Diethyl ether or petroleum ether was added at a ratio of 1:3, extracted twice, the extracts were combined, the ether or petroleum ether was recovered, and the residual solvent was removed by drying under reduced pressure to obtain an effective active site. Preparation Example 3: Preparation of Volatile Components of Fermented Cordyceps Powder by Steam Distillation

[0025] The Cordyceps fungus powder was distilled with 10 times the volume (V / W) of water for 5 hours, and the volatile oil was collected to obtain a yellow transparent oil.

[0026] The above preparation examples are used to further illustrate the preparation method of the present invention, but they are not intended to limit the scope of th...

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PUM

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Abstract

The invention relates to a method for preparing active part of fermented Cordyceps sinensis bacteria powder and its application for treating respiratory disease. Said active part is fat soluble active part of fermented Cordyceps sinensis bacteria powder, and can be called Cordyceps sinensis oil or fermented Cordyceps sinensis bacteria powder oil, which comprises nonpolar component such as unsaturated fatty acid, saturated fatty acid, ester, alkane and polar component with macromolecular weight. The method comprises three kinds of processes: CO2 supercritical flow extraction and separation; extraction with fat soluble organic dissolvent such as ether and ligroine; water steam evaporation. The active part can prevent and treat chronic obstructive pulmonary disease such as asthma, chronic bronchitis and pneumonectasis, allergic rhinitis and cough. It can be produced into medicine, health-care foodstuff and foodstuff addictive. The active part of fermented Cordyceps sinensis bacteria powder greatly increases the effect for treating respiratory disease, and is characterized by defined treating effect, small intake dose, easy to controllable effective component content and easier absorption.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicine, a health care product or the active part made from the active part of fermented Cordyceps fungus powder, which is directly used as a food additive for the treatment and prevention of asthma, chronic bronchitis or emphysema, etc. Chronic obstructive pulmonary disease (COPD), allergic rhinitis, cough. Background technique [0002] Asthma is a common chronic allergic airway inflammatory disease that requires long-term control with drugs. In my country, the incidence rate of asthma in adults is 0.7%-1.5%, and that in children is 1.1-2.3%. That is to say, there are 10 million to 20 million patients nationwide, most of whom are young adults and children. Clinical treatment mainly uses chemical drugs such as hormones and receptor agonists to control the symptoms of asthma. Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic bron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61K9/08A61K9/16A61K9/20A61K9/48A61K9/70A61K9/00A61P11/04A61P11/06A61P11/14A61P11/00
Inventor 王勤科葛凯勤陆丽莉吴大勇江礼发
Owner 王勤科
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