Application of rosmarinic acid in the preparation of medicines for treating or preventing liver fibrosis and kidney fibrosis

A technology of rosmarinic acid and liver fibrosis, applied in the application field of medicine, can solve problems such as unreported pharmacological effects and the like

Inactive Publication Date: 2008-01-02
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the pharmacological effects of rosmarinic acid in the preparation of prevention or treatment of liver fibrosis and renal fibrosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Preparation of rosmarinic acid freeze-dried powder for injection

[0011] Take 50.0g of rosmarinic acid, add 2000ml of water for injection to dissolve it, adjust the pH to 5.5-7.5 with NaOH, add 8g of mannitol, stir to dissolve, ultra-filter to obtain a pyrogen-free clear solution, pour it into a 10ml vial, 2ml / piece, freeze-dried according to the freeze-dried powder injection process to make each freeze-dried powder injection containing 50.0mg of rosmarinic acid.

Embodiment 2

[0012] Example 2 Preparation of Rosmarinic Acid Tablets

[0013] prescription:

[0014] Rosmarinic acid 100.0g

[0015] Powdered sugar 35.0g

[0016] Lactose 40.0g

[0017] Sodium carboxymethyl starch 23.0g

[0018] 3% PVP K30 Aqueous solution

[0019] Magnesium Stearate 2.0g

[0020]

[0021] A total of 1000 pieces were made

[0022] Operation: Weigh the prescription amount of rosmarinic acid, powdered sugar, lactose and sodium carboxymethyl starch, mix well and pass through a 100-mesh sieve, add 3% PVP K30 Appropriate amount of water solution to make soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, granulate with 18-mesh sieve, add the prescribed amount of magnesium stearate, mix well, punch out tablets with dimples, adjust the weight of the tablets to about 200mg, and get ready.

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PUM

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Abstract

The invention provides the application of rosmarinic acid for preparing medicine that treats or prevents liver and kidney fibrosis. The medicine can be oral liquid or injection, and the dosage for injection is 50 -1500mg, and for oral liquid is 100-3000mg.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to the application of rosmarinic acid in the preparation of medicines for preventing or treating liver fibrosis and kidney fibrosis. Background technique: [0002] Liver fibrosis is an important pathological feature of chronic liver disease. Viruses, ethanol, autoimmune diseases and other etiologies can cause liver cell necrosis, regeneration and persistent fibrous proliferation, eventually leading to cirrhosis. It has been confirmed that liver fibrosis is a reversible disease, while liver cirrhosis is irreversible. Therefore, in the treatment of chronic liver disease, the prevention and treatment of liver fibrosis plays an important role. [0003] Renal fibrosis (including renal interstitial fibrosis and glomerulosclerosis) is the main pathological basis of the final stage of renal damage caused by various reasons. The proliferation and activation of stromal cells are related to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P1/16A61P13/12
CPCA61K9/19A61K9/2018A61K9/2027A61K31/192A61P1/16A61P13/12A61P43/00
Inventor 蒋王林曲桂武田京伟
Owner SHANDONG LUYE PHARMA CO LTD
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