Anti-cancer composition containing estramustine
A technology of estramustine and composition, applied in the field of anticancer composition, can solve the problems of enhanced tolerance, treatment failure and the like
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Embodiment 1
[0118] Put 80, 80 and 80 mg of p(BHET-EOP / TC) (BHET-EOP: TC is 80: 20) copolymers into three containers of A, B and C respectively, and then add 100 ml of dichloromethane to each , after dissolving and mixing, add 20mg dasatinib, 20mg estramustine, 10mg dasatinib and 10mg estramustine respectively, shake up again and prepare 20% dasatinib, 20 % estramustine, and 10% dasatinib and 10% estramustine microspheres for injection. Then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension-type sustained-release injection. The release time of the slow-release injection in physiological saline in vitro is 65-75 days, and the release time in mice subcutaneously is more than 65 days.
Embodiment 2
[0120] The method step of being processed into slow-release injection is identical with embodiment 1, but difference is that used auxiliary material is the p(BHET-EOP / TC) of 50: 50, containing anticancer active ingredient and weight percent thereof are:
[0121] (1) Estramustine 10%; or
[0122] (2) A combination of 10% tipifarnib and 10% estramustine.
Embodiment 3
[0124] Put 70 mg of p(LAEG-EOP) with a peak molecular weight of 10,000-25,000 into three containers of A, B, and C, respectively, and then add 100 ml of dichloromethane to each, dissolve and mix well, and pour into the three containers respectively Add 30mg sunitinib, 30mg estramustine, 20mg sunitinib and 10mg estramustine, shake up again and use spray drying method to prepare 30% sunitinib, 30% estramustine, 20 % sunitinib and 10% estramustine injection microspheres. The dried microspheres are suspended in physiological saline containing 1.5% sodium carboxymethylcellulose to prepare the corresponding suspension-type sustained-release injection. The release time of the slow-release injection in physiological saline in vitro is 65-68 days, and the release time in mice subcutaneously is about 65 days.
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