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Hot expansion continuous microflow high pressure gradient pump for high-performance liquid chromatographer

A high-performance liquid chromatography and thermal expansion technology, applied in the field of thermal expansion continuous micro-flow high-pressure gradient pump, can solve problems such as difficulty, change of split ratio, and reduction of solvent usage.

Inactive Publication Date: 2007-10-24
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, traditional liquid-phase pumps have great difficulty in accurately delivering micro-flow flow
Current commercial instruments often use split technology, but there are also some defects that are difficult to overcome, such as changes in the front pressure of the column can easily cause changes in the split ratio; moreover, the split technology does not really reduce the amount of solvent used

Method used

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  • Hot expansion continuous microflow high pressure gradient pump for high-performance liquid chromatographer
  • Hot expansion continuous microflow high pressure gradient pump for high-performance liquid chromatographer
  • Hot expansion continuous microflow high pressure gradient pump for high-performance liquid chromatographer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] 1. Prepare a pump cavity of a stainless steel tube with an inner diameter of 5 mm and a length of 56 mm, and the volume of the pump cavity is 1100 μL.

[0047] 2. Using a fused silicon capillary with an inner diameter of 250 μm as the liquid storage capillary, the design length is 3 m, and the liquid storage volume is 147.2 μL. A single pump can work for more than one hour without switching at a flow rate of 2 μL.

[0048] 3. The liquid storage bottle is connected to the ten-way valve 6 through a polytetrafluoroethylene tube with a filter on the head. The ten-way valve, three-way, four-way and pressure sensor are all connected by 7μm inner diameter stainless steel pipes, and the length should be as short as possible.

[0049] 4. Computers, sampling devices, chromatographic columns, detectors, etc. use common products, use control circuit boards to communicate with temperature sensors, pressure sensors and computers, and use micro-flow pump control software to make the m...

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Abstract

The invention belongs to instrument technical field, in particular to a thermal expansion continuous micro-flow high-pressure gradient pump of high-effect liquid spectrometer, composed of a pressure-resistance heating pump, a micro-flow pump control system, a switch valve, a pressure sensor, and a liquid bottle connected in turn. The invention uses the theory of liquid thermal expansion, via pre / real-time calculation to control the heating process of heated liquid, to obtain micro-flow at 10-5 to 10-9L / min level via increasing temperature, as constant flow, linear gradient liquid flow and other types, and the output pressure can reach 10-35MPa. And the invention uses a valve switch system to realize automatic alternative operation of two pump groups, to confirm continuous output of micro flow, and realize at least binary flow equal / gradient watch, and uses dual-pressure balance point exchange technique, to confirm stable flow speed and stable pressure in pump switch.

Description

technical field [0001] The invention belongs to the technical field of instruments and meters, and in particular relates to a thermal expansion continuous microflow high-pressure gradient pump for microcolumn or capillary high-performance liquid chromatography. technical background [0002] The progress of micro-electro-mechanical processing technology (MEMS) has greatly promoted the development of miniaturization of analytical instruments. In the "Frontier Technology of Modern Scientific Instruments and Analytical Science - The 140th Symposium of Xiangshan Science Conference" (May 2000), Many academicians and professors also agreed that the development direction of the entire analytical instrument in the future is mainly miniaturization, integration, and intelligence on this basis. [0003] For high performance liquid chromatography (HPLC), miniaturization has particular significance. Compared with conventional liquid chromatography, the micro-column high-performance liqui...

Claims

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Application Information

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IPC IPC(8): G01N30/34G01N30/36
Inventor 张祥民陶芊纪杰
Owner FUDAN UNIV
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