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Compound coenzyme Q10 medicine prepn and its prepn process and application

A pharmaceutical preparation, coenzyme technology, applied in the field of medicine, to achieve the effect of stable quality and good appearance

Inactive Publication Date: 2007-08-22
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] It has been reported that coenzyme Q10 deficiency is particularly prone to occur in patients with aging and ischemic heart disease, elderly cardiosclerosis and hypertension

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: (1) prescription: A medicine 10g B medicine 500g mannitol 500g

[0026] (2) Add an appropriate amount of water for injection to the above three drugs, stir to dissolve, adjust the pH value, add water for injection to the specified amount, mix well, add 0.5% activated carbon for needles, boil for 30 minutes, coarse filter, fine filter, filtrate Subpackaging, freeze-drying, the equilibrium time of the first stage when the equilibrium freezing temperature is 0°C is 2.5 hours, that is, the time when the shelf temperature is basically consistent with the product temperature; the second stage freezing temperature is from 0°C to the lowest eutectic temperature- At 16°C, the equilibrium time between the shelf temperature and the product temperature is 2.5 hours; the third stage continues to cool down to -45°C, which takes about 2 hours, and maintains this temperature for 2 hours until the product is completely frozen, that is, starts vacuuming and enters drying Pr...

Embodiment 2

[0029] Embodiment 2: (1) prescription: A medicine 10g B medicine 100g mannitol 100g

[0030] (2) Add an appropriate amount of water for injection to the above three drugs, stir to dissolve, adjust the pH value, add water for injection to the specified amount, mix well, add 0.5% activated carbon for needles, boil for 30 minutes, coarse filter, fine filter, filtrate Subpackaging, freeze-drying, the equilibrium time of the first stage when the equilibrium freezing temperature is 0°C is 2.5 hours, that is, the time when the shelf temperature is basically the same as the product temperature; the second stage freezing temperature is from 0°C to the lowest eutectic temperature- At 16°C, the equilibrium time between the shelf temperature and the product temperature is 2.5 hours; the third stage continues to cool down to -45°C, which takes about 2 hours, and maintains this temperature for 2 hours until the product is completely frozen, that is, it starts vacuuming and enters drying Pro...

Embodiment 3

[0033] Embodiment 3: (1) prescription: A medicine 8g B medicine 24000g

[0034](2) Take the above two medicines, add an appropriate amount of water for injection to dissolve, add 0.5% activated carbon according to the volume, boil, keep boiling slightly for 30 minutes, filter slightly cold, add water for injection to the filtrate to the specified amount, and then boil after adjusting the pH value. Refrigerate overnight at 4°C, coarsely filter, finely filter, add water for injection, subpackage, seal and sterilize to obtain the injection.

[0035] A Drug: Coenzyme Q10

[0036] Drug B: troxerutin, inosine, ATP, glycerol fructose, coenzyme A, amino acids, citicoline

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PUM

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Abstract

The present invention is one kind of compound coenzyme Q10 medicine preparation and its preparation process and application. The compound coenzyme Q10 medicine preparation is prepared with coenzyme Q10 and one or two of troxerutin, inosine, ATP, glyceryl fructose, coenzyme A, amino acid, nicholin and vitamins. It is used mainly for improving energy metabolism, assisting treatment of cardiac and cerebral vascular diseases, such as ischemic heart disease, senile myocardial sclerosis, etc, and promoting the synthesis of ATP.

Description

technical field [0001] The invention relates to a compound coenzyme Q10 pharmaceutical preparation and its preparation method and application, belonging to the technical field of medicines. technical background [0002] It has been reported that Coenzyme Q10 deficiency is particularly prone to occur in patients with aging and ischemic heart disease, elderly myocardial sclerosis and hypertension. From the perspective of improving energy metabolism, medical scientists have been exploring the clinical application value of coenzyme Q10 since the 1960s. Coenzyme Q10 is now on the market as a drug, including tablets, capsules and injections. It is mainly used to improve the energy metabolism of the body and cooperate with the treatment of cardiovascular and cerebrovascular diseases, such as: ischemic heart disease, senile myocardial sclerosis, hypertensive heart disease etc. And it has the effect of promoting the body to synthesize ATP. Troxerutin, inosine, ATP, glycerol fructos...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/7076A61K31/7004A61K31/195A61K31/714A61K31/7068A61K9/00A61K9/08A61K9/20A61P9/10A61P9/12A61K31/122
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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