Compound preparation of antimalarial and its preparing method

A prescription and filler technology, applied in the field of medicine, can solve the problems of missed doses by patients, inability to guarantee patient compliance with treatment, and protection of drug resistance, etc., so as to improve the dissolution rate, improve bioavailability, and avoid direct contact. Effect

Inactive Publication Date: 2007-07-18
桂林制药有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With this packaging method, patients often miss a certain drug, and the patient's compliance with treatment cannot be guaranteed, thus affecting the protection of drug resistance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] 1. Prescription of amodiaquine hydrochloride layer granules

[0063] Prescription composition dosage use

[0064] Amodiaquine Hydrochloride 200mg active ingredient

[0065] Starch 10% Bulking agent

[0066] Sucrose 7% Bulking agent

[0067] Polysorbate 80 0.05% Solubilizer

[0068] Starch Paste 3% Binder

[0069] Hypromellose 3% Disintegrant

[0070] Microcrystalline Cellulose 3% Disintegrant

[0071] Magnesium Stearate 1% Lubricant

[0072] 2. Isolation layer particle prescription

[0073] Prescription composition dosage use

[0074] I Starch 60% Filler

[0075] Sucrose 15% Bulking agent

[0076] Dextrin 20% Bulking

[0077] Rouge 0.1‰ colorant

[0078] Starch Paste 3% Binder

[0079] Magnesium Stearate 1% Lubricant

[0080] II Ethylcellulose 0.8% Coating material

[0081] Polyvinylpyrrolidone 0.2% Coating material

[0082] 3. Prescription of artesunate layer granules

[0083] Prescription composition dosage use

[0084] I Artesunate 50mg active ingre...

Embodiment 2

[0107] 1. Prescription of amodiaquine hydrochloride layer granules

[0108] Prescription composition dosage use

[0109] Amodiaquine Hydrochloride 200mg active ingredient

[0110] Starch 7% Bulking agent

[0111] Dextrin 6% Bulking

[0112] Sodium Lauryl Sulfate 1% Solubilizer

[0113] Starch paste 5% binder

[0114] Hypromellose 3% Disintegrant

[0115] Microcrystalline Cellulose 3% Disintegrant

[0116] Sodium starch glycolate 3% Disintegrant

[0117] Magnesium Stearate 1% Lubricant

[0118] 2. Isolation layer particle prescription

[0119] Prescription composition dosage use

[0120] I Starch 40% Bulking agent

[0121] Sucrose 30% Bulking agent

[0122] Dextrin 25% Bulking

[0123] Carmine 0.1‰ colorant

[0124] Starch Paste 3% Binder

[0125] Magnesium Stearate 1% Lubricant

[0126] II Hypromellose 0.9% Coating material

[0127] Polyethylene glycol 4000 0.1% Coating material

[0128] 3. Prescription of artesunate layer granules

[0129] Prescription compo...

Embodiment 3

[0144] 1. Prescription of amodiaquine hydrochloride granules

[0145] Prescription composition dosage use

[0146] Amodiaquine Hydrochloride 200mg active ingredient

[0147] Starch 6% Bulking agent

[0148] Dextrin 5% Bulking

[0149] Polysorbate 80 0.1% Solubilizer

[0150] Hypromellose Solution 4% Binder

[0151] Hydroxypropyl Cellulose 4% Disintegrant

[0152] Microcrystalline Cellulose 4% Disintegrant

[0153] Sodium starch glycolate 4% Disintegrant

[0154] Magnesium Stearate 1% Lubricant

[0155] 2. Isolation layer particle prescription

[0156] Prescription composition dosage use

[0157] I starch 50% filler

[0158] Lactose 30% Filler

[0159] Dextrin 12% Bulking

[0160] Indigo 0.1‰ colorant

[0161] Powdered Sugar Starch Paste 6% Binder

[0162] Magnesium Stearate 1% Lubricant

[0163] II Acrylic resin No. IV 0.8% Coating material

[0164] Castor oil 0.2% Coating material

[0165] 3. Prescription of artesunate layer granules

[0166] Prescription co...

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PUM

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Abstract

A three-layer compound antimalarial tablet is composed of an amodiaquine hydrochloride layer, an isolating layer and an artesunate layer. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an antimalarial drug and a preparation method thereof. Background technique [0002] Malaria (malaria), also known as the pendulum, is a parasitic disease that is widely prevalent in the world. It is a vicious infectious disease caused by Plasmodium through mosquito vectors. After infected female mosquitoes bite people, Plasmodium enters the human body The blood circulates, then invades the liver and reproduces, enters the blood again after 9-16 days, and begins to infect red blood cells, resulting in periodic periodic episodes of chills, high fever, sweating and fever reduction, as well as symptoms and signs such as anemia and splenomegaly. Four species of Plasmodium species cause malaria, the deadliest of which is malaria falciparum, the world's most devastating human parasitic infection. [0003] The unique diseases caused by each Plasmodium show different morphological characteristic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/20A61K31/4706A61K31/357A61P33/06
Inventor 严啸华龚秋燕庞丽凌广才潘梅郑清四
Owner 桂林制药有限责任公司
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