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Medicine for treating benign prostate hyperplasia and method of its preparation

A prostatic hyperplasia and benign technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as urethral extrusion, dysuria, etc., achieve reduced wet weight and dry weight, and high bioavailability , the effect of reducing residual urine volume

Inactive Publication Date: 2009-10-14
ZHEJIANG CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difficulty urinating due to increased prostate tissue that presses against the urethra

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation of capsules

[0055] Weigh according to the prescription: 300g astragalus, 180g peach kernel, 180g zedoary, 20g rhubarb, 240g smilax, 400g coix seed, 300g motherwort, 300g prunella vulgaris, 120g cinnamon, 180g bellflower, 180g bean root, and 180g achyranthes bidentata.

[0056] Take cinnamon, rhubarb, coix seed (50% or 200g), and peach kernel (5% or 9g), mix and grind them into fine powder; extract the volatile oil from Curcuma with steam distillation for 8 hours, put the aqueous solution in a container for later use, and keep the medicinal residue. Take the volatile oil and use 6 times the amount of β-cyclodextrin to get inclusions; decoct and extract Astragalus three times, adding 8 times water each time, decocting for 1.5 hours, combining three decoctions, filtering, and concentrating until the relative density is 1.05-1.35 (measured at 70°C), take it out, let it cool, add ethanol to make the ethanol content reach 60%, leave it for 24 hours, filter, and ...

Embodiment 2

[0058] Weigh according to the prescription: Astragalus 310g, peach kernel 200g, curcuma 190g, rhubarb 20g, Smilax 250g, coix seed 400g, motherwort 310g, Prunella vulgaris 300g, bellflower 152g, cinnamon 0g, bean root 258g, Sichuan achyranthes bidentata 190g.

[0059] Take cinnamon, rhubarb, coix seed 50% (ie 200g), and peach kernel 5% (ie 10g) and mix and grind into fine powder; Zedoary decoction pieces are steam-distilled to extract volatile oil for 6 hours, put the aqueous solution in a container for later use, and keep the drug residue. Take the volatile oil, and use 5 times the amount of β-cyclodextrin to get inclusions; decoct and extract Astragalus three times, add 6 times of water each time, decoct for 1 hour, combine three decoctions, filter, and concentrate to a relative density of 1.05-1.35 (measured at 70°C), take it out, let it cool, add ethanol to make the ethanol content reach 40%, leave it for 18 hours, filter, and get ethanol liquid; the remaining peach kernel 1...

Embodiment 3

[0061] Tablet preparation

[0062] Weigh according to the prescription: 516g of astragalus, 51.6g of peach kernel, 258g of curcuma, 0g of rhubarb, 77.4g of Smilax tuckahoe, 619.2g of coix seed, 129g of motherwort, 516g of Prunella vulgaris, 206.4g of cinnamon, 77.4g of bellflower, 51.6g of bean root, Sichuan Achyranthes bidentata 77.4g.

[0063] Take 61.92 g of cinnamon, rhubarb, coix seed, and 15.48 g of peach kernel, mix and grind them into fine powder; extract the volatile oil from curcuma decoction pieces by steam distillation for 8 hours, put the aqueous solution in a container for later use, and keep the drug residue. Take the volatile oil, and use 7 times the amount of β-cyclodextrin to get inclusions; Astragalus is decocted and extracted three times, adding 10 times of water each time, decocting for 3 hours, combining three decoctions, filtering, and concentrating until the relative density is 1.05-1.35 (measured at 70°C), take it out, let it cool, add ethanol to make...

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Abstract

The invention relates to a medicine for treating benign prostatic hyperplasia and a preparation method thereof. Composed of pharmaceutical excipients. The preparation method is to crush cinnamon, rhubarb, coix seed, and peach kernel into fine powder; extract volatile oil from curcuma decoction pieces; Decoction pieces, zedoary dregs, water-extracted filtrate and astragalus ethanol liquid are combined and concentrated to make a dry paste, crushed, sieved, added zedoary volatile oil and fine powder of cinnamon and other drugs, and made into various preparations with medicinal excipients. The preparation can obviously inhibit the hyperplasia of prostate tissue induced by testosterone, significantly reduce the wet weight and dry weight of each leaf of the prostate, has no obvious toxic effect, and is safe and reliable; the preparation method has high bioavailability, good drug effect, stable quality and easy control.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation and a preparation method thereof, in particular to a medicine for treating benign prostatic hyperplasia and a preparation method thereof. The name of the medicine is Huang'e Tongguan Capsule. Background technique [0002] The prostate gland is made up of glands and muscles that grow with age. Their overgrowth can cause benign prostatic hyperplasia. Difficulty urinating due to the increase in prostate tissue, causing compression on the urethra. As the pace of life continues to accelerate, the number of patients with benign prostatic hyperplasia is increasing day by day. According to data, patients with benign prostatic hyperplasia tend to be younger. BPH is not cancer, nor can it turn into cancer; these benign growths of the prostate gland are slow and do not spread to other parts of the body. However, the two diseases may coexist at the same time. Modern medical research b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/899A61K36/896A61K36/73A61K36/708A61K36/59A61K36/54A61K36/536A61K36/533A61K36/481A61K36/34A61K36/21A61P13/08
Inventor 贾金铭
Owner ZHEJIANG CONBA PHARMA
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