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Medicine for treating senile dementia and its preparing process

An senile dementia and senile technology, applied in pharmaceutical formulations, drug combinations, drug delivery and other directions, it can solve the problems of limited patient ratio and duration, and the effect is not very obvious, and achieve the effect of small single dose, suitable taste and stable quality.

Inactive Publication Date: 2009-07-22
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Dementia patients often have decreased cholinergic nerve function, so currently cholinesterase inhibitors are mainly used for treatment, which can reduce the degradation of acetylcholine and increase the local acetylcholine content, so as to achieve the purpose of controlling certain symptoms, and often have different degrees of adverse reactions , in terms of preventing the decline of patients' cognitive function, the proportion and duration of benefited patients are extremely limited
[0005] Traditional Chinese medicine and natural medicines for dementia are mainly intelligence-inducing and improving cerebral blood flow, and the effect is not very obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Weigh the raw materials according to the following ratio:

[0047] Codonopsis 7.5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg, Poria 7.5kg

[0048] The production method is as follows:

[0049] Take cassia twigs and add water to distill to obtain volatile oil, and volatile oil is re-distilled 3 times to obtain refined volatile oil; take other raw materials, add water to soak, combine the medicinal residues after extracting volatile oil, decoct and extract twice, separate the extracts, combine, and filter The filtrate is concentrated under reduced pressure to a relative density of about 1.10 (50°C), and allowed to cool; take the above-mentioned concentrated solution, add ethanol until the alcohol content reaches 75%, let it stand, and filter; the filtrate recovers ethanol under reduced pressure, and concentrates to a relative density of about 1.24 (80°C); take the above concentrate, add volatile oil, appropriate amount of aspartame sugar, add water to 10000ml, stir w...

Embodiment 2

[0051] Weigh the raw materials according to the following ratio:

[0052] Codonopsis 7.5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg, Poria 7.5kg

[0053] Dried ginger 5kg Polygala 4.5kg Shichangpu 5kg keel 15kg and oyster 15kg

[0054] The production method is as follows:

[0055] Take cassia twig and dried ginger, add water to distill to produce volatile oil, volatile oil redistilled 3 times to get refined volatile oil; take other raw materials, soak in water, combine the medicinal residues after extracting volatile oil, decoct and extract twice, separate the extracts, combine , filtered; the filtrate was concentrated under reduced pressure to a relative density of about 1.10 (50°C), and allowed to cool; the above concentrated solution was taken, added ethanol until the alcohol content reached 75%, left standing, and filtered; the filtrate was decompressed to recover ethanol and concentrated to The relative density is about 1.24 (80°C); take the above concentrated solut...

Embodiment 3

[0057] Weigh the raw materials according to the following ratio:

[0058] Codonopsis 5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg

[0059] Poria cocos 5kg dried ginger 5kg polygala 3kg stone calamus 5kg

[0060] and oysters 15kg;

[0061] The production method is as follows:

[0062] Take the above raw materials and crush them into particles. Take cinnamon sticks and dried ginger, and use supercritical CO 2 Extraction, separate the aromatic oil; Add water and dynamic heating to extract the medicinal residues and other raw materials for 2 hours, separate the extract, filter; take the filtrate, concentrate under reduced pressure to a relative density of about 1.09 (50°C), let cool; take the above concentrated liquid, add ethanol until the alcohol content reaches 75%, let it stand, and filter; the filtrate recovers ethanol under reduced pressure, and concentrates to a relative density of about 1.22 (80°C); take the above concentrated solution, add aromatic oil, appropriat...

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Abstract

The invention discloses a new medicine for treating senile dementia, which is composed of Codonopsis pilosula, Guizhi, Radix Paeoniae Alba, Poria cocos and licorice as main raw materials and / or pharmaceutically acceptable carriers. The medicine of the present invention is also effective for vascular dementia. The invention also discloses a preparation method of the medicine.

Description

technical field [0001] The invention relates to a medicine for treating senile dementia, specifically a Chinese patent medicine prepared from traditional Chinese medicine, and also relates to a preparation method of the medicine. Background technique [0002] Senile dementia (AD) is a neurodegenerative disease that seriously endangers the health of the elderly in today's society. At present, the number of patients worldwide has reached 12 million. In my country, there are more than 5 million elderly patients with dementia, most of whom are Alzheimer's. [0003] The pathogenesis of senile dementia has not yet been fully elucidated. The main clinical feature is the slow emergence of mental decline, including the decline of memory, thinking, understanding, judgment, calculation and other functions and varying degrees of personality changes, but there is no disturbance of consciousness. Senile dementia has become the fourth leading cause of death of the elderly after heart disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K36/71A61K36/69A61K36/54A61K36/484A61K36/344A61K36/076A61K35/56A61K35/02A61K9/08A61K9/10A61P25/28
Inventor 林水淼赵伟康张宁周如倩
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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