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Fresh cordate medicinal preparation and preparing method therefor

A technology of fresh Houttuynia cordata preparations, which is applied in the fields of pharmaceutical formulations, pill delivery, antibacterial drugs, etc., can solve the problems of limited application, no single flavor fresh Houttuynia cordata preparations, and difficulty in preservation of fresh Houttuynia cordata. Achieve the effect of increasing dissolution rate, retaining medicinal value, improving bioavailability and curative effect

Inactive Publication Date: 2009-06-03
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral preparations include Compound Houttuynia Tablets, Compound Houttuynia Dropping Pills, Compound Houttuynia Granules and Houttuyniatin Sodium Tablets, but there is no single fresh Houttuynia preparation
According to our pharmacy and pharmacological experiments, we found that fresh Houttuynia cordata has strong anti-inflammatory effect. Clinical practice found that the curative effect of fresh Houttuynia cordata preparation is obviously better than that of dried Houttuynia cordata preparation, but fresh fish Houttuynia cordata is difficult to preserve, which limits its clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Take fresh Houttuynia cordata extract, add appropriate amount of water, place on a macroporous resin polyamide column, elute with 0% to 95% gradient ethanol, collect the total flavonoids, then recover ethanol, concentrate, and vacuum dry, Pass through an 80-mesh sieve to obtain 200 g of total flavonoid compound dry powder. Take another volatile oil of fresh Houttuynia cordata, with the mass ratio of volatile oil and β-cyclodextrin 1:4, slowly drop the volatile oil into saturated β-cyclodextrin aqueous solution, keep the temperature at 60°C, stir for 4 hours, let stand, overnight, Filter and dry, and pass through a 60-mesh sieve to obtain 40 g of inclusion compounds of volatile oil. Take 100 g of total flavonoid dry powder and 30 g of volatile oil clathrate, mix well, granulate, dry, sieve, put into capsule shells, and make 1000 capsules.

Embodiment 2

[0021] Example 2: Take fresh Houttuynia cordata extract, add appropriate amount of water, place on a polyamide column, elute with 0% to 95% gradient ethanol, collect total flavonoids, then recover ethanol, concentrate, vacuum dry, pass through 80 mesh Sieve to obtain dry powder 320g of total flavonoids. Take another volatile oil of fresh Houttuynia cordata, with the mass ratio of volatile oil and β-cyclodextrin 1:10, slowly drop the volatile oil into saturated β-cyclodextrin aqueous solution, keep the temperature at 60°C, stir for 4 hours, let it stand, overnight, Filter and dry, and pass through a 60-mesh sieve to obtain 100 g of inclusion compounds of volatile oil. Take 200 g of dry powder of total flavonoids and 60 g of volatile oil clathrate, mix well, granulate, granulate, compress into tablets, and make 1000 tablets.

Embodiment 3

[0022] Example 3: Take fresh Houttuynia cordata extract, add appropriate amount of water, place on a silica gel column, elute with 0% to 95% gradient ethanol, collect total flavonoids, then recover ethanol, concentrate, vacuum dry, and pass through a 80-mesh sieve Obtain 200 g of dry powder of total flavonoids. Take another volatile oil of fresh Houttuynia cordata, with the mass ratio of volatile oil and β-cyclodextrin 1:6, slowly drop the volatile oil into saturated β-cyclodextrin aqueous solution, keep the temperature at 60°C, stir for 4 hours, let stand, overnight, Filter and dry, and pass through a 60-mesh sieve to obtain 60 g of inclusion compounds of volatile oil. Take 250g of total flavonoid dry powder and 75g of volatile oil clathrate, mix well, granulate, dry, sieve, put into capsule shells, and make 1000 capsules.

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PUM

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Abstract

The present invention discloses a fresh houttuynia oral preparation and its preparation method. The active component of the described preparation is formed from dried powder of total flavone compound extracted from fresh houttuynia extract and fresh houttuynia volatile oil inclusion compound. Said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a fresh houttuynia medicinal preparation and a preparation method thereof. Background technique [0002] Houttuynia cordata is the aerial part of Houttuynia cordata Thumb., a plant of the family Tribaceae. It is a medicinal material for both medicine and food. It mainly contains volatile oils, flavonoids, organic acids, amino acids and other compounds. Spicy and cold in nature, it has the effects of clearing away heat and detoxification, eliminating carbuncle and expulsion of pus, diuresis and treating stranguria. The research on dried Houttuynia cordata has confirmed its immune function and good phlegm-resolving, cough-relieving, asthma-relieving and diuretic effects. . In the spring of 2003 when the SARS virus was prevalent, Houttuynia cordata injection was listed as one of the eight anti-SARS Chinese patent medicines, so its efficacy is certain. Existing Houttuynia cordata preparati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/16A61K9/20A61K9/48A61P31/04
Inventor 洪佳璇孙静芸汪柏尧高雅文冯丙江
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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