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Meso-porous nanometer particle of calcium phosphate, preparation method and application thereof

A mesoporous calcium phosphate and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of poor biodegradability and biological activity, difficult to identify mononuclear phagocytes, and reduce the content of drugs in other tissues, achieving low prices and abundant sources of drugs. , the effect of high drug loading

Inactive Publication Date: 2009-02-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The properties of materials have an important influence on the release and absorption of drugs. Studies have shown that organic polymer materials have the following defects as drug carriers: first, their solubility in the body is low, which affects absorption; and proteins in blood are easily adsorbed to The surface of the carrier causes the burst release of the drug; in addition, it will be swallowed by the reticuloendothelial system, reducing the drug content in other tissues, and the hydrophilic inorganic material can reduce the burst release and is not easily recognized by mononuclear phagocytes
Although mesoporous silica and carbon nanotubes are good for drug loading, they are poor in biodegradability and bioactivity

Method used

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  • Meso-porous nanometer particle of calcium phosphate, preparation method and application thereof
  • Meso-porous nanometer particle of calcium phosphate, preparation method and application thereof
  • Meso-porous nanometer particle of calcium phosphate, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 14g of dodecyl phosphate and dissolve in the mixed solution of 30ml deionized water and 30ml ethanol, add 15ml 0.5mol·L -1 Ca 2+ solution and 15ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 2mol·L -1 NaOH solution to adjust the pH value to 10, and then evaporate and reflux at 90°C for 24 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:

[0031] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , Dodecyl Phosphate 0.88mol L -1 .

[0032] TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 40-100 nm and a length of 5-10 μm (Fig. 1(a), Fig. 1(b)). The pores are evenly distributed, which is conducive to drug loading. The specific surface area is 160m 2 g -1 , with an average pore size of 3.5nm ( Figure 4 ), the pore volume is 0.21cm 3 g -1 . XRD...

Embodiment 2

[0035] Weigh 12g of cetyl phosphate and dissolve it in a mixed solution of 20ml deionized water and 20ml ethanol, and add 10ml of 0.5mol·L -1 Ca 2- solution and 10ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 3mol·L -1 NaOH solution to adjust the pH value to 8, and then evaporate and reflux at 100°C for 12 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:

[0036] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , cetyl phosphate ester 0.93mol L -1 .

[0037] The specific surface area of ​​the obtained mesoporous calcium phosphate nanopowder is 210m 2 g -1 , the pore volume is 0.23cm 3 g -1 , the average pore size is 5.2nm.

[0038] The TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 90-120nm and a length of 6-8μm, and the pores are evenly distributed, ...

Embodiment 3

[0040] Weigh 16g of octadecyl phosphate and dissolve it in a mixed solution of 25ml deionized water and 25ml ethanol, and add 12ml of 0.5mol·L -1 Ca 2+ solution and 12ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 4mol·L -1 NaOH solution to adjust the pH value to 9, and then evaporate and reflux at 110° C. for 36 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:

[0041] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , Octadecyl Phosphate 0.91mol·L -1 .

[0042] The specific surface area of ​​the obtained mesoporous calcium phosphate nanopowder is 240m 2 g -1 , with a pore volume of 0.25 cm 3 g -1 , with an average pore size of 7.5nm.

[0043] The TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 100-120nm and a length of 8-7μm. The pores are evenly dist...

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Abstract

The invention dis closes a nanomater granule of mesoporous calcium phosphate which is used as medicine carrier. It comprises Ca10(PO4)6(OH)2, the crystalline is nanometer banded shape, the width of band is 40-150 nm, length is 5-10 um, specific surface area is 160-280 m2.g-1 and the acverage bore diameter is 3-8 nm. The said prepartion process comprises following steps: adding phosphate radical solution, calcium ion solution in order into solution containing surface active agent and cosurfactant, getting mixing solution; dripping alkaline liquor slowly and stirring at the same into mixing solution to regulate pH to 8-11; stirring for reaction for 1-48 hours and getting reaction product of white deposition; washing white deposition with organic dissolvent and water and getting nanomater granule of mesoporous calcium phosphate. The product is characterized by no toxicity, good biocompatibility, high medicine carrying amount and a certain degradability.

Description

technical field [0001] The invention relates to a nano material, in particular to a mesoporous calcium phosphate nano particle. [0002] The present invention also relates to a preparation method of the above-mentioned nanoparticles. [0003] The present invention also relates to the application of the mesoporous calcium phosphate nanoparticles Background technique [0004] Drug carrier is a kind of biomaterial product that gradually rises with the development of biomaterial science, clinical medicine and pharmacology. The drug enters the human body through the carrier, and the adsorption, encapsulation and bonding of the drug by the carrier make the drug release site, speed and mode etc. selective and controllable, realizing the slow release and targeted delivery of the drug, so as to better play the role of drug therapy Effect. The rapid development of nano-biotechnology provides important enlightenment and opportunities for its application in the field of biomedicine. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02C01B25/32
Inventor 王迎军张淑花魏坤
Owner SOUTH CHINA UNIV OF TECH
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