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Water gel containing natural high molecule and its radiation preparing method

A technology of natural polymer and hydrogel, applied in the field of hydrogel, can solve the problems of unsatisfactory formula and process, and achieve the effects of good absorption, good biocompatibility and good biodegradability

Inactive Publication Date: 2008-05-21
厦门凝赋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention is an early technology in the development of hydrogel wound dressings. Similar processes have been put into production in China, Japan, Poland and other countries. capability has put forward higher requirements, and the formula and process involved in this invention can no longer meet these requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] After mixing polyvinyl alcohol / carboxyethyl chitosan / water in a weight ratio of 10 / 3 / 87, inject it into a mold, vacuum seal it, and irradiate 25kGy with an electron beam. The resulting hydrogel has antibacterial properties and a water absorption rate of 20000%, reaching swelling balance in 2 hours, and the tensile strength and elongation at break are more than doubled compared with pure polyvinyl alcohol gel.

Embodiment 2

[0024] After mixing polyvinylpyrrolidone / carboxymethylcellulose / water at a weight ratio of 5 / 5 / 90, pour it into a mold, vacuum seal it, and irradiate 25kGy with γ-rays, the obtained hydrogel has ideal strength without air bubbles , The water absorption rate is 10000%.

Embodiment 3

[0026] After mixing carboxymethyl cellulose / activated carbon / water at a weight ratio of 15 / 5 / 80, injecting into a mold, vacuum packaging, and irradiating 25kGy with γ-rays, the strength of the hydrogel containing inorganic materials obtained is comparable to that of pure carboxymethyl Compared with cellulose (CMC) hydrogel, it is more than 2 times higher, without air bubbles, and its water absorption capacity is equivalent to that of pure CMC hydrogel.

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Abstract

The present invention provides one kind of water gel containing natural high molecular material and its preparation process. The water gel has cross-linking degree of 70-95 % and water absorption of 500-80000 %, and contains natural high molecular material or its derivative selected from chitin, chitin derivative, chitosan, chitosan derivative, carrageenin, etc. The water gel may have synthetic high molecular material, inorganic filler, cross-linking sensitizer, medicine and other assistant added. It is prepared through radiation cross-linking, with the radiation dosage being 10-40 kGy. The water gel of the present invention has high water absorption, high flexibility, good medicine slow releasing performance, and may be used in wound dressing, etc.

Description

technical field [0001] The invention relates to a hydrogel, in particular to a hydrogel containing a natural polymer and a preparation method thereof. The hydrogel is suitable for but not limited to the field of biomedical materials. Background technique [0002] Hydrogel is a polymer material similar to living tissue. It is composed of a polymer network that is insoluble in water but swellable and water. Large heat capacity and other properties, widely used in food, medicine and other fields. One of the important uses of medical hydrogel is as a wound dressing. This kind of wound dressing suitable for wound protection of wounds, burns and surgical incisions has many advantages compared with traditional dressings such as gauze, and is known as the "ideal dressing". , these advantages include: (1) transparent, strong and elastic; (2) can fully absorb body fluid and prevent its loss; (3) can effectively shield bacteria; (4) has good adhesion to the skin but is beneficial to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08L1/08C08L89/00C08L39/06C08L29/04C08L71/08C08K3/00A61K31/715A61P29/00A61P31/00
Inventor 翟茂林许零彭静魏根拴李久强
Owner 厦门凝赋生物科技有限公司
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