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System and method of perfusion imaging and ultrasonic control releasing based-on capsule microbubble

A technology of perfusion imaging and microbubbles, which is applied in ultrasonic therapy, echo/ultrasound imaging agent, ultrasonic/acoustic/infrasonic diagnosis, etc. It can solve the problems of high development cost, high hardware requirements, complex composition, etc., and improve the extraction accuracy , Intuitive image, small calculation effect

Inactive Publication Date: 2008-05-07
XI AN JIAOTONG UNIV
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Problems solved by technology

Combining the respective advantages of the above imaging modes, some new imaging technologies have been developed, such as pulse inversion harmonic power Doppler imaging, multi-pulse release imaging and other imaging modes. These imaging methods have high requirements for hardware and their composition is relatively complex. , higher development cost

Method used

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  • System and method of perfusion imaging and ultrasonic control releasing based-on capsule microbubble
  • System and method of perfusion imaging and ultrasonic control releasing based-on capsule microbubble
  • System and method of perfusion imaging and ultrasonic control releasing based-on capsule microbubble

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preparation example Construction

[0069] The present invention does not involve the preparation of coated microbubbles, and the coated microbubbles mentioned in the present invention can be commercial contrast microbubbles, such as Levovist from Schering in Germany, SonoVue from Bracco in Italy, etc.

[0070] The present invention also does not involve the preparation of drug-carrying contrast agent, and its preparation method can adopt the Chinese invention patent "Ultrasound contrast agent with concurrent drug and gene targeting carrier" ZL03114567.1 (disclosure date August 27, 2003, Publication No. 1438037) method. The present invention only provides a fine ultrasonic controlled release method of coated microbubbles.

[0071] According to the fifth aspect of the present invention, there is provided an effective cooperative targeting and destroying ultrasonic sequence control method, that is, an alternating sequence of low-amplitude continuous sine waves and low-amplitude pre-correction chirps + short-time z...

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Abstract

A system based on envelope microvesicle for perfusion imaging and ultrasonic controlled release is composed of ultrasonic imaging probe, fully digitalized ultrasonography B, RF data output port, high-speed data acquisition card, PC as main controller, any waveform generator, 3D moving unit, moving controller and single-cell transducer. On the basis of fully digitalized ultrasonography B, a blood perfusion imaging algorithm is used for making a decision to obtained original RF data and performing real-time imaging. Under the guide of perfusion image, the release of envelope microvesicles is controlled.

Description

technical field [0001] The invention belongs to the technical field of ultrasonic diagnosis and treatment equipment, and relates to a system and method integrating ultrasonic microvascular perfusion imaging and ultrasonic positioning control release of coated microbubbles guided by the perfusion image. Background technique [0002] Ultrasound microbubble contrast agent (microbubble Ultrasound Contrast Agent, mUCA) has strong echo scattering performance and unique acoustic characteristics, and is currently considered to be the best contrast material in human microvessels. In microvascular detection and tissue perfusion imaging, the use of microbubble contrast agents has the advantages of good imaging effects, real-time, easy operation, no ion radiation, non-destructive, and wide application. Perfusion imaging is of great significance to the evaluation of clinical cardiovascular disease diagnosis and treatment process. In addition to being used as diagnostic agents, ultrasoun...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B8/00A61B5/06A61K49/22G06F19/00A61N7/00
Inventor 万明习吴方刚樊华宋延淳王素品
Owner XI AN JIAOTONG UNIV
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