Compound injection from ice tablet and Danshen Root extract and its preparation thereof
A technology for injection preparations and extracts, applied in the field of compound injections, can solve the problems of low bioavailability, slow absorption of borneol, and low content of borneol
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Embodiment 1
[0046] Embodiment 1: the preparation of salvia miltiorrhiza extract
[0047] Take 10 kg of Danshen medicinal material, add 10 times the amount of water, boil and extract twice, each time for 1.0 hour, and collect the extract; then use 80% ethanol to extract twice, each time for 0.5 hour, and collect the extract. The collected extracts were concentrated, dried and mixed separately. That is, Danshen extract.
Embodiment 2
[0048] Example 2: Preparation of Danbing Injection [1]
[0049] Take 10g of borneol, grind it finely, add 1000ml of glycerin, heat and stir to dissolve completely. Take Danshen extract 10g and add 2-4L water for injection to dissolve. Slowly add the glycerol solution of borneol into the aqueous solution of the salvia miltiorrhiza extract, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 10,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.
Embodiment 3
[0050] Example 3: Preparation of Danbing Injection [2]
[0051] Take 10g of borneol, grind it finely, add an appropriate amount of absolute ethanol to dissolve it, then slowly add it to a saturated aqueous solution prepared with 600g of hydroxypropyl-β-cyclodextrin, keep warm at 40-60°C, stir or sonicate to clarify the solution. Take another 20g of Danshen extract, add appropriate amount of water for injection to dissolve. Slowly add the hydroxypropyl-β-cyclodextrin inclusion solution of borneol into the aqueous solution of the salvia miltiorrhiza extract, stir, and add an isotonic osmotic pressure regulator to dissolve when making an infusion. The osmotic pressure regulator is At least one of mannitol, sodium chloride or glucose, diluted to 20L with water for injection, and mixed well. The liquid medicine is ultrafiltered through an ultrafiltration membrane with a pore size of 30,000-100,000 molecular weight, potted, 10ml / bottle, and sterilized to obtain an injection.
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