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Compound injection from ice tablet and Danshen Root extract and its preparation thereof

A technology for injection preparations and extracts, applied in the field of compound injections, can solve the problems of low bioavailability, slow absorption of borneol, and low content of borneol

Inactive Publication Date: 2007-11-14
JIANGSU CAREFREE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The distribution half-life of borneol for intravenous administration is 2.8 minutes, and it is quickly distributed to tissues and organs to exert curative effect, while the half-life of oral elimination is 5.3 hours, indicating that borneol is absorbed slowly and has low bioavailability
The content of borneol in a few injections such as Xinnaojing injection and Qingkailing injection is also very low, it is difficult to reach the effective concentration of the drug and affect the curative effect
[0007] The compound preparation of Danshen extract combined with borneol alone has not been seen so far, and no reports have been found in relevant research literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: the preparation of salvia miltiorrhiza extract

[0047] Take 10 kg of Danshen medicinal material, add 10 times the amount of water, boil and extract twice, each time for 1.0 hour, and collect the extract; then use 80% ethanol to extract twice, each time for 0.5 hour, and collect the extract. The collected extracts were concentrated, dried and mixed separately. That is, Danshen extract.

Embodiment 2

[0048] Example 2: Preparation of Danbing Injection [1]

[0049] Take 10g of borneol, grind it finely, add 1000ml of glycerin, heat and stir to dissolve completely. Take Danshen extract 10g and add 2-4L water for injection to dissolve. Slowly add the glycerol solution of borneol into the aqueous solution of the salvia miltiorrhiza extract, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 10,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.

Embodiment 3

[0050] Example 3: Preparation of Danbing Injection [2]

[0051] Take 10g of borneol, grind it finely, add an appropriate amount of absolute ethanol to dissolve it, then slowly add it to a saturated aqueous solution prepared with 600g of hydroxypropyl-β-cyclodextrin, keep warm at 40-60°C, stir or sonicate to clarify the solution. Take another 20g of Danshen extract, add appropriate amount of water for injection to dissolve. Slowly add the hydroxypropyl-β-cyclodextrin inclusion solution of borneol into the aqueous solution of the salvia miltiorrhiza extract, stir, and add an isotonic osmotic pressure regulator to dissolve when making an infusion. The osmotic pressure regulator is At least one of mannitol, sodium chloride or glucose, diluted to 20L with water for injection, and mixed well. The liquid medicine is ultrafiltered through an ultrafiltration membrane with a pore size of 30,000-100,000 molecular weight, potted, 10ml / bottle, and sterilized to obtain an injection.

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PUM

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Abstract

A Chinese medicine in the form of injection for treating cardiovascular and cerebrovascular diseases such as cerebral infarction, cerebral ischemia, coronary heart disease, angina pectoris and myocardial infarction is proportionally prepared from borneol and red sage root through extracting their active components.

Description

technical field [0001] The invention relates to a compound injection composed of traditional Chinese medicine borneol and salvia miltiorrhiza extract in a certain proportion and a preparation method thereof. It belongs to the field of medical technology. Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among urban population, tumors accounted for the first place, and cerebrovascular diseases accounted for the second place. Disease takes second place. Ischemic cereb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K31/045A61K9/08A61K9/14A61K9/19A61P9/00
Inventor 秦引林何龙其
Owner JIANGSU CAREFREE PHARM CO LTD
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