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Wireless sensing platform for multi-analyte sensing

a multi-analyte, wireless technology, applied in the field of implantable analyte sensing systems, can solve the problems of large scale use of continuous monitoring platforms that requires fundamentally new technologies, large size, high cost, etc., and achieve the effect of minimizing cost and increasing value for chronic applications

Pending Publication Date: 2022-04-28
INTEGRATED MEDICAL SENSORS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]In accordance with the present invention, a platform based system for in-vivo multi-analyte monitoring is disclosed. The platform includes an extremely small size wireless implantable sensor enabling continuous monitoring and resulting in increased value for chronic applications due to minimal foreign body response. The components of the system can be fabricated at minimized cost by utilizing standard and scalable materials and manufacturing methods (e.g., conventional integrated circuit fabrication methods).
[0008]Lithographically integrated systems allow extreme miniaturization and can be used to produce extremely small sensors in accordance with the invention. CMOS based sensors have been proposed in other works [1]. In accordance with some embodiments of the invention, herein is presented a complete wireless health monitoring platform using a dynamic design to provide the reliability, yield and performance specifications required for clinical applications while managing environment variations and regulatory requirements. Furthermore, the presented design can be completely integrated on a unitary semiconductor platform and can provide advantages over other sensing platforms that consist of several different components to be bonded together [2], [3] in a complicated and failure-prone manner.
[0009]Some advantages of the invention presented here as compared to prior art include: (i) disclosure of a complete wireless sensing platform with design of all system components, (ii) disclosure of an integrated sensing element in close proximity to potentiostat and signal processing circuit (iii) disclosure of a dynamic, adaptively matched wireless powering and communication scheme that allows for reliable operation, (iv) disclosure of a dynamic control circuit design that keeps sensor measurement range at an optimal level throughout operation, (v) the use of standard wireless communication protocols that minimizes error rates, (vi) the use of patterned electrodes (e.g., patterned during semiconductor fabrication) that provide for higher sensor sensitivity, yield, reliability, and (vii) the use of custom functionalization methods, and processing to achieve high yield for volume production of sensors.

Problems solved by technology

However, large scale use of continuous monitoring platforms requires fundamentally new technologies.
The disadvantages of the current technologies include their high complexity, large size and high cost.
These macro (from few cm to few mm) scale devices need special implantation procedures, are prone to rejection by the body due to the immune system response, need bulky power supply systems which have a limited battery life, and have high manufacturing costs associated with utilizing and integrating discrete components.

Method used

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  • Wireless sensing platform for multi-analyte sensing
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Examples

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Embodiment Construction

[0054]The present invention is directed to a sensing platform that can be used in a variety of in-vitro, ex-vivo and in-vivo applications providing continuous measurement of one or more types of health or biological markers (e.g., metabolites and / or analytes). For purposes of illustration and without loss of generality, in-vivo electrochemical measurement of one or more analytes are referred to in this example. As a person having ordinary skill in the art will appreciate, the described devices, systems and methods can be more generally applied to other analyte and sensing modalities; including but not limited to wired sensors; sensors with power storage capability, sensors powered with other modalities such as those described elsewhere in this document, industrial sensors; sensors comprising optical, capacitive, or mechanical sensing elements; physical measurements such as temperature, vibration, pressure, light, electromagnetic radiation, or sound of any frequency including but not...

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Abstract

Monitoring of one or more key indicators can provide powerful insights into operation and state of different physical systems. For example, continuous monitoring of multiple analyte in body will allow for detailed insights into personal health and will allow for preventative health management. In this application, we present an ultra-small scale wireless sensing platform capable of long-term wireless in-vivo sensing. The key for extreme miniaturization lies in ultra-low-power compact design and lithographic integration of key system components. The key to low cost is using standard technologies and scalable manufacturing. For example, using standard semiconductor technologies for sensing, processing and wireless operation paves way to a low-cost integrated wireless sensing technology. Modern semiconductor technologies provide the capability to provide low-power and yet powerful electronics functionality in a small (mm-scale) size and wireless operation at high frequency. Furthermore, these technologies also present the possibility of integrating different components through wafer-scale lithographic integration. This application presents optimal design and processing methods for a small wireless multi-analyte sensing platform that can be used to monitor multiple analyte such as glucose, lactate, Urea and other physicochemical quantities and operates wirelessly. The design techniques and processing methods presented in this application can be used for a multitude of other applications and are not limited to those described here.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of U.S. application Ser. No. 16 / 612,391, filed on Nov. 10, 2019, entitled “WIRELESS SENSING PLATFORM FOR MULTI-ANALYTE SENSING,” currently pending; which is a National Phase of PCT International Application No. PCT / US2018 / 031629 filed on May 8, 2018; which claims priority to U.S. Provisional Application No. 62 / 527,525, filed Jun. 30, 2017. The entire contents of all the above applications is hereby incorporated by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH[0002]This invention was made with government support under contract no. R43DK109811-01, and no. R43DK111001-01 awarded by the National Institutes of Health, and contract no. 1621991 awarded by the National Science Foundation. The government has certain rights in the invention.BACKGROUNDTechnical Field of the Invention[0003]The present invention is directed to implantable analyte sensing systems and more specifically to a low-cost...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/00A61B5/145A61B5/1473
CPCA61B5/0031A61B5/002A61B2560/0219A61B5/1473A61B5/7275A61B5/14532A61B5/14546
Inventor NAZARI, MEISAM HONARVARMUJEEB-U-RAHMAN, MUHAMMADSENCAN, MEHMET
Owner INTEGRATED MEDICAL SENSORS INC
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