Multilayer Compositions, Coated Devices And Use Thereof
a technology of coating device and composition, applied in the direction of viruses/bacteriophages, antibody medical ingredients, dna/rna vaccination, etc., can solve problems such as conversion and instability, and achieve the effects of reducing the risk of developing pathology, and reducing the severity
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[0111]In this Example, rapid hypodermic-needle-free DNA delivery was demonstrated, using microneedle patches that implant multi-layer polymer films into the epidermis following a brief application to skin. Biodegradable multi-layer films carrying DNA, a polymeric transfection agent, and adjuvant molecules implanted in murine skin both efficiently transfected cells in the local tissue and elicited immune responses comparable to in vivo electroporation of plasmid DNA (pDNA), one of the most promising current technologies for DNA vaccine delivery.
[0112]To substantially enhance DNA vaccine delivery, an approach was designed to simultaneously (i) improve targeting of DNA to tissues rich in immune response-governing dendritic cells, (ii) promote sustained transfection without toxicity, (iii) and provide supporting inflammatory cues to enhance the induction of a potent immune response. To this end, a strategy was developed using microneedles to rapidly and painlessly implant biodegradable ...
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