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Plant extracts for improving cognitive function

a technology of plant extracts and cognitive function, applied in the direction of plant/algae/fungi/lichens, biocide, drug composition, etc., can solve the problems of inconsistent findings and current cognitive health products that only show benefits

Pending Publication Date: 2016-06-16
KEMIN IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent involves using a natural plant extract called rosmarinic acid to improve cognitive health. The inventions describe how this extract can help improve memory, reasoning, attention / concentration, planning, mood, and sleep. The technical effect of this patent is to provide a more consistent and effective way to improve overall cognitive health through chronic supplementation with natural plant extracts.

Problems solved by technology

Current cognitive health products have only shown benefit in acute, cross-over study, and have inconsistent findings.

Method used

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  • Plant extracts for improving cognitive function
  • Plant extracts for improving cognitive function
  • Plant extracts for improving cognitive function

Examples

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example 1

[0048]An efficacy study was conducted on the spearmint extract in order to evaluate its potential in improving learning and memory in a SAMP8 mouse model of accelerated aging (U.S. patent application Ser. No. 13 / 962,609, filed Aug. 8, 2013, and incorporated herein by this reference). SAMP8 mice were administered spearmint extract or vehicle control. In addition, a 50% SAMP8 backcross strain served as the control which also received vehicle. After 90 days of treatment mice were tested in 3 behavioral tests which included, T-maze foot shock avoidance, object recognition and lever press. The spearmint extract improved acquisition (at both 16 and 32 mg of active / kg body weight) and retention (at all doses) in T-maze. In addition, spearmint with rosmarinic acid improved object recognition at 16 and 32 mg / kg body weight. The mouse doses of 16 and 32 mg of active / kg body weight correlate to a human equivalent dose of 91-180 mg rosmarinic acid, or 600-1200 mg of spearmint extract containing...

example 2

[0051]In a randomized, double-blind, placebo-controlled study, the effects of spearmint extract was evaluated on measures of cognitive performance, sleep, mood, and tolerability in men and women with age-associated memory impairment (AAMI). The objective of this trial was to evaluate the acute and chronic effects of two doses (600 mg or 900 mg) of a proprietary spearmint extract on aspects of cognitive function in men and women with AAMI.

[0052]Method: Participants (N=90; 67% female; age=59.4±0.6 y) were randomly assigned (n=30 / group) to consume 900, 600, or 0 mg / day spearmint extract for 90 days. A computerized assessment for cognitive performance, subjective cognition, mood, and sleep were completed on days 0, 45, and 90. Fasting blood samples, vital signs, and adverse events were collected to assess tolerability.

[0053]Results: In the current study, the quality of working memory and spatial working memory accuracy improved following supplementation with 900 mg / day spearmint extract...

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Abstract

Extracts of plants of the Lamiaceae family, including the Mentha genus, are shown to have a positive impact on overall cognitive health, including improvements in memory, reasoning, attention / concentration, planning, mood, sleep and associated behaviors.

Description

[0001]This application is a continuation application of U.S. patent application Ser. No. 14 / 855,003, filed Sep. 15, 2015, which claims priority to U.S. Patent Application 62 / 050,563, filed Sep. 15, 2014, which is incorporated herein in its entirety by this reference.BACKGROUND OF THE INVENTION[0002]There is a strong demand for products that can improve cognitive health or function and the market for these products has continued to grow in recent years despite the unfavorable economic pressures. Some of this growth can be attributed to the growth of an aging population, which is especially true in Asia and the United States. Worldwide cognitive health ingredient sales are around $455 million. Frost and Sullivan have predicted an annual growth rate in this area to 12% from 2016 to 2019.[0003]Major ingredients for cognitive health currently include phosphatidylserine (PS), CoQ10, omega-3 (marine oils / algae oils), citicoline, ginkgo and ginseng. Of the largest cognitive health ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/534A61K31/216A61K36/53
CPCA61K31/216A61K36/53A61K36/534A61P25/20A61P25/24A61P25/28A61K2300/00A61P25/00
Inventor CEDDIA, MICHAELHERRLINGER, KELLILEWIS, BRANDONFENG, SHULINNIEMAN, KRISTIN
Owner KEMIN IND INC
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