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Use of glycopyrrolate for treating tachycardia

a technology of tachycardia and glycopyrrolate, which is applied in the direction of biocide, drug composition, dispersed delivery, etc., can solve the problems of difficult to determine the rhythm's regularity, sign of digitalis toxicity, and anxiety, and achieve the effect of reducing the risk of strok

Inactive Publication Date: 2014-03-20
SOSEI R&D LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a device for inhaling a specific treatment for tachycardia. This device contains unit doses (specific amounts) of the treatment. The technical effect is that this device provides a convenient and effective way to treat or prevent tachycardia.

Problems solved by technology

It may be difficult to determine the rhythm's regularity when the rate exceeds 150 beats per minute.
It tends to be a regular, narrow complex tachycardia and may be a sign of digitalis toxicity.
In susceptible individuals, this sensation can even induce anxiety.
This can then lead to breathlessness or chest pain or in rare circumstances myocardial infarction, or acute on chronic heart failure.
Tachyarrythmias may cause dizziness, fainting and black outs etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0142]37 g of magnesium stearate are mixed with 1 kg of crystalline glycopyrronium bromide in a Turbula® blender for 5 hours. The resulting mixture is micronised using a Hosokawa Alpine® 100 AFG fluid bed opposed jet mill with the following parameters: classifier speed, 13000 rpm; milling gas pressure, 3.5 bar. The mill is equipped with 3 nozzles of 1.9 mm diameter.

[0143]The resulting mixture has a median particle size of about 3 micron (x90=7 micron, x50=3 micron, x10=1 micron). The magnesium stearate is well distributed over the drug substance surface.

[0144]Lactose carrier particles (99.7% w / w of final composition) are admixed to give an inhalable dry powder.

example 2

[0145]Drug substance 1: 50 g of magnesium stearate are mixed with 1 kg of crystalline glycopyrronium bromide in a Turbula® blender for 5 hours. The resulting mixture is micronised using a Hosokawa Alpine® 100 AFG fluid bed opposed jet mill (equipped with 3 nozzles of 1.9 mm diameter) with the following parameters: classifier speed, 13000 rpm; milling gas pressure, 3.5 bar, to give particles that have an average particle size of less than 5 microns.

[0146]Drug substance 2: 1 kg of crystalline glycopyrronium bromide is micronised using a Hosokawa Alpine® 100 AFG fluid bed opposed jet mill (equipped with 3 nozzles of 1.9 mm diameter) with the following parameters: classifier speed, 13000 rpm; milling gas pressure, 3.5 bar, to give particles that have an average particle size of less than 5 microns.

[0147]These drug substances are used to prepare the following formulations:

[0148]Formulation 1: Lactose carrier particles (99% w / w of final composition) are admixed with drug substance 2 to gi...

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Abstract

The invention relates to a novel use of the antimuscarinic agent glycopyrrolate, for example the salt glycopyrronium bromide. In particular, the invention relates to glycopyrrolate for use as a heart rate lowering agent and more particularly, but not exclusively, for use in patients suffering from respiratory conditions such as chronic obstructive pulmonary disease.

Description

FIELD OF THE INVENTION[0001]The invention relates to a novel use of the antimuscarinic agent glycopyrrolate, for example the salt glycopyrronium bromide. In particular, the invention relates to glycopyrrolate for use as a heart rate lowering agent and more particularly, but not exclusively, for use in patients suffering from respiratory conditions such as chronic obstructive pulmonary disease.BACKGROUND OF THE INVENTION[0002]Tachycardia is a type of arrhythmia which presents with a high heart rate, typically above 100 for an adult. The disorder results in a speeding of normal heart rhythm which is known as sinus tachycardia and which may be brought about by a number of factors, such as exercise, anemia, fever, anxiety, pregnancy or drugs. Alternatively, sinus tachycardia may be caused by an underlying pathological condition as a result of an arrhythmia.[0003]An electrocardiogram (ECG) is typically used to classify the type of arrhythmia. Tachycardias may be classified as either narr...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K45/06A61M15/00
CPCA61K31/40A61K45/06A61M15/0028A61K9/0075A61K31/167A61K31/4704A61M15/0045A61M15/009A61M2202/064A61K9/0078A61P11/00A61P43/00A61P9/00A61P9/06A61K2300/00A61K9/14
Inventor SNAPE, SUSANTANSLEY, ROBERT
Owner SOSEI R&D LIMITED
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