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Methods for treating hepatocellular carcinoma

a hepatocellular carcinoma and composition technology, applied in the field of compositions for the treatment of hepatocellular carcinoma, can solve the problems of hyper-stabilization of the microtubule structure, limited effectiveness of most chemotherapeutic agents, and inability to improve the survival rate of patients, so as to promote the assembly of microtubules, promote the activity of molecule activity, and promote the effect of microtubules

Inactive Publication Date: 2014-03-20
ABRAXIS BIOSCI LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018]The methods described herein can be used for any one or more of the following purposes: alleviating one or more symptoms of HCC, delaying progressing of HCC, shrinking tumor size in HCC patient, inhibiting HCC tumor growth, prolonging overall survival, prolonging disease-free survival, prolonging time to HCC disease progression, preventing or delaying HCC tumor metastasis, reducing (such as eradiating) preexisting HCC tumor metastasis, reducing incidence or burden of preexisting HCC tumor metastasis, preventing recurrence of HCC.

Problems solved by technology

Nevertheless, most chemotherapeutic agents show limited effectiveness and have not been able to improve patient survival.
Paclitaxel binds to the β subunit of tubulin, the building blocks of microtubules, causing hyper-stabilization of the microtubule structures.
Although paclitaxel has been shown to be effective against various malignant tumor cells such as breast cancer, melanoma, and ovarian cancer, its effectiveness against HCC has been questioned.

Method used

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  • Methods for treating hepatocellular carcinoma
  • Methods for treating hepatocellular carcinoma
  • Methods for treating hepatocellular carcinoma

Examples

Experimental program
Comparison scheme
Effect test

example 1

Evaluation of Efficacy of Nanoparticle (Nab-Paclitaxel) in In Vitro and In Vivo Hepatocellular Carcinoma (HCC) Models

[0175]This example demonstrates the activity of Nab-paclitaxel in in vitro and in vivo HCC models.

Materials and Methods

Expression Profiling and Informatic Analysis

[0176]Gene expression profiling on 43 paired HCC tumors and adjacent non-tumoral livers was performed according to method described by Wong N. et al., Clinical Cancer Research 11:1319-26 (2005). Demographic information of cases studied is shown in Table 1. Normal liver RNA from three individuals were pooled and used as reference control in array hybridisation (Ambion, Austin, Tex.; Clontech Laboratory Inc., Palo Alto, Calif.; and Strategene, La Jolla, Calif.). Briefly, reverse-transcribed RNA from test sample and normal liver pool were differentially labelled with fluorescent Cy5-dCTP or Cy3-dCTP. Labelled cDNAs were co-hybridised onto 19K cDNA arrays (Ontario Cancer Institute, Canada). Hybridised signals ca...

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Abstract

The present invention provides methods and compositions for treating hepatocellular carcinoma (HCC) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating HCC comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent, such as an agent that inhibits microtubule disassembly.

Description

TECHNICAL FIELD[0001]The present invention relates to methods and compositions for the treatment of hepatocellular carcinoma (HCC) by administering compositions comprising nanoparticles that comprise a taxane and an albumin.BACKGROUND[0002]Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. See Parkin D. M., Lancet Oncology 2:533-43 (2001). The disease is often diagnosed late in the course of clinical manifestation. As a result, only 10-15% of patients are candidates for curative surgery. For the majority of HCC patients, systemic chemotherapies or supportive therapies are the mainstay treatment options. Nevertheless, most chemotherapeutic agents show limited effectiveness and have not been able to improve patient survival. See e.g., Yeo W. et al., J. of the National Cancer Institute 97:1532-8 (2005), Gish R. G. et al., J. of Clinical Oncology 25:3069-75 (2007), Ramanathan R. K. et al., J. of Clinical Onc...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/51A61K31/352A61K31/713A61K31/337A61K45/06
CPCA61K9/5169A61K31/337A61K45/06A61K31/713A61K31/352A61P35/00A61P35/04A61K2300/00A61K47/42A61K9/14
Inventor YEO, WINNIEWONG, NATHALIE
Owner ABRAXIS BIOSCI LLC
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