Coaxial dual function probe and method of use

Abstract

An energy delivery probe for use in tissue ablation and method of use is presented. The energy delivery device has at least a first energy delivery member and a second energy delivery member that have handle members positioned along a longitudinal axis, each handle member having a proximal and distal end. The distal end of the first handle member is releasably coupled to the proximal end of the second handle member and a portion of each member is defined in a coaxially surrounding relationship to each other along the longitudinal axis. The method of using the probe involves identifying a tissue to be ablated, providing the energy delivery probe, inserting at least a portion of the energy delivery probe into the identified tissue, delivering electrical energy through the energy delivery probe to the identified tissue, and ablating the identified tissue such that at least a first ablation zone is formed.

Description

BACKGROUND OF THE INVENTION[0001]The present application relates generally to devices and methods for tissue treatment using Irreversible Electroporation (IRE). More specifically, the application relates to devices and methods for treatment of tissue through the application of pulsed electric fields that create nonthermal cellular effects and, that can be applied at a level of sufficient strength so as to result in ablation of tissue.[0002]The application of an electric field to transiently permeabilize cells is a method known as reversible electroporation. In reversible electroporation, membrane defects are created and later reseal, allowing a time when macromolecules can be introduced across the cell membrane. This has been used, for example, to insert genes-into cells (electrogenetherapy), and to insert anti-cancer drugs into cells (electrochemotherapy). A primary goal of reversible electroporation is to lead to cellular defects that allow passage of macromolecules while still al...

AI Technical Summary

Problems solved by technology

A limitation of such commercially available IRE probes is that such devices function primarily as either a bipolar probe device or a monopolar probe device, and there is typically very little, if any, cross-functionality between such devices, such that if a practitioner desires to use one device as a bipolar device and another device as a monopolar device, one electrosurgical device may have to be removed and replaced with a different device in order to switch between a bipolar and a monopolar treatment, thereby causing disruption to the patient and increased procedure time.

Another problem associated with current IRE devices is that during a single IRE ablation, a practitioner may desire, to adjust the ablation volume of a target tissue while minimizing the potential disruption to a patient from the removal and reinsertion of all of the electrodes into the patient's tissue.

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