Bioerodible matrix for tissue involvement

Abstract

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 12 / 705,177, filed Feb. 12, 2010, which claims priority to U.S. Provisional Patent Application No. 61 / 164,344, filed Mar. 27, 2009, the entire disclosures of which are incorporated herein by this reference.FIELD OF THE INVENTION[0002]The present invention generally relates to medical implants for reconstruction, augmentation and / or wound healing and more specifically relates to such implants including a polymer component and a cellular component.BACKGROUND OF THE INVENTION[0003]Often following damage such as a surgical incision, skin can benefit from additional support to promote wound healing. This is in part because spontaneous recovery can require a long period of time and pain can continue throughout the repair process.[0004]Repair of soft tissue defects also is critical following reconstructive and augmentative surgeries. For example, more than 250,000 reconstructive procedures are p...

AI Technical Summary

Benefits of technology

The bioresorbable matrices offer immediate strength and support for incision sites, facilitate tissue replacement, and reduce the risk of malpositioning or capsular contracture around breast implants by providing a beneficial interface with host tissue, ultimately promoting effective wound healing and soft tissue reconstruction.

Problems solved by technology

This is in part because spontaneous recovery can require a long period of time and pain can continue throughout the repair process.

Women afflicted with breast cancer, congenital defects or damage resulting from trauma have very few alternatives to reconstruction.

These current materials used to promote wound healing or for soft tissue reconstruction or augmentation, however, still suffer from shortcomings such as suboptimal volume retention, donor site morbidity, and in some instances, continued poor biocompatibility.