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Methods of Delivering a Health Care Active by Administering Personal Health Care Articles Comprising a Filament

Inactive Publication Date: 2012-07-05
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0069]The personal health care articles of the present invention may also provide one or more health benefits. Non-limiting examples of health benefits can include respiratory benefits, gastrointestinal benefits, CNS benefits, anti-infection benefits, nutritional benefits, overall wellbeing benefits, and combinations thereof.

Problems solved by technology

The water in the formula adds to the weight and size of the products and translates into greater shipping and storage costs.
Additionally, these types of products also have disadvantages in terms of packaging, storage, transportation, and convenience of use.
It can also be difficult to control the dosing of liquid personal health care products.
Moreover, the presence of water in personal health care products increases susceptibility to degradation of water unstable ingredients and promotes negative interactions between two or more incompatible materials in an article.
It can be inconvenient for a user to find a drink to consume a personal health care product in this form.
However, they are not durable and tend to break when the user transports them and often have a chalky flavor.
Furthermore, pediatric and geriatric patients have difficulty swallowing larger oral dosage forms.
However, these strips have a low loading capacity which limits the variety and amount of personal health care actives that can be added to the dosage form.
Furthermore, these strips and the processes for making the strips do not offer the flexibility and rates of production that personal health care articles comprising one or more filaments offer.

Method used

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  • Methods of Delivering a Health Care Active by Administering Personal Health Care Articles Comprising a Filament
  • Methods of Delivering a Health Care Active by Administering Personal Health Care Articles Comprising a Filament
  • Methods of Delivering a Health Care Active by Administering Personal Health Care Articles Comprising a Filament

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0253]The following personal health care article can be prepared in accordance with the present invention:

ComponentWt % of Processing MixtureEthylex 2035 Starch132.13% Naproxen-Na9.64%Polyox WSR N-60K PEO20.07%Distilled Waterq.s.Total 100%1Ethylex ™ 2035 Starch available from Tate & Lyle (London, United Kingdom)2Polyox ® WSR N-60K PEO available from Dow (Midland, Michigan)

[0254]Example 1 can be made by the following procedure. The distilled water is put into an appropriately sized and cleaned vessel and then is stirred at 100-300 revolutions per minute (rpm) and heated to 80° C. The Ethylex™ 2035 and the Polyox® are weighed into a suitable container and are slowly added to the heated distilled water in small increments using a spatula. The Ethylex™ 2035 and Polyox® are added to the distilled water and continuously stirred at 80° C. until the Ethylex™ 2035 and Polyox® are dissolved resulting in the filament-forming mixture.

[0255]The filament-forming mixture is cooled to 25° C., then ...

example 2

[0258]The following personal health care article can be prepared in accordance with the present invention:

ComponentWt % of Processing MixtureCelvol 523 Polyvinyl Alcohol319.56% Doxylamine Succinate4.46%FD&C Blue #10.09%Sucrose2.13%Distilled Waterq.s.Total 100%3Celvol ® 523 available from Sekisui Corporation (Dallas, Texas)

[0259]Example 2 can be made by the following procedure. The distilled water is put into an appropriately sized and cleaned vessel and then is stirred at 100-300 rpm and heated to 80° C. The Celvol® 523 is weighed into a suitable container and is slowly added to the heated distilled water in small increments using a spatula. The Celvol® 523 is gradually added to the distilled water and continuously stirred at 80° C. until the Celvol® is dissolved resulting in the filament-forming mixture.

[0260]Then, the sucrose and blue #1 are slowly added to the filament-forming mixture. The temperature of the filament-forming mixture with the sucrose and blue #1 is maintained at 8...

example 3

[0262]The following personal health care article can be prepared in accordance with the present invention:

ComponentWt % of Processing MixtureCelvol 523 Polyvinyl Alcohol12.64%Naproxen-Na13.83%Doxylamine Succinate 0.39%Vanilla 1.10%Dextromethorphan HBr 0.94%Propylene Glycol10.11%Distilled Waterq.s.Total  100%

[0263]Example 3 can be made by the following procedure. The propylene glycol is put into an appropriately sized and cleaned vessel and then is stirred at 100-300 rpm at 25° C. The dextromethorphan HBr is weighed into a suitable container and is slowly added to the propylene glycol in small increments using a spatula. The propylene glycol and dextromethorphan HBr are stirred continuously at 100-300 rpm at 25° C. until the dextromethorphan HBr dissolves. The propylene glycol dextromethorphan HBr mixture is set aside.

[0264]In a separate vessel, the distilled water is put into an appropriately sized and cleaned vessel and then is stirred at 100-300 rpm and heated to 80° C. The Celvol...

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Abstract

A method of delivering a health care active having the steps of administering to a mammal in need of a health benefit or a treatment for a health condition a personal health care article and consuming the article. The article contains one or more filaments that contain a backbone material, a health care active and optionally aesthetic agents, extensional aids, plasticizers, and crosslinking agents.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 360,982, filed Jul. 2, 2010; U.S. Provisional Application Ser. No. 61 / 361,126, filed Jul. 2, 2010; U.S. Provisional Application No. 61 / 361,129, filed Jul. 2, 2010; U.S. Provisional Application Ser. No. 61 / 361,135, filed Jul. 2, 2010; U.S. Provisional Application Ser. No. 61 / 361,146, filed Jul. 2, 2010; U.S. Provisional Application Ser. No. 61 / 361,154, filed Jul. 2, 2010; and U.S. Provisional Application Ser. No. 61 / 361,159, filed Jul. 2, 2010.FIELD OF THE INVENTION[0002]The present invention relates to methods of delivering a health care active by administering to a mammal a personal health care article, especially those personal health care articles that can comprise one or more nonwoven webs. The nonwoven webs can comprise one or more filaments. The filaments can comprise backbone materials and health care actives. The invention further relates to methods of ...

Claims

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Application Information

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IPC IPC(8): A61M31/00
CPCA61K9/0056A61K9/7007A61K47/10A61K47/36D01F1/10A61K31/44D04H3/16D01D4/025A61K9/70A61K31/192D04H1/728A61P1/00A61P11/00A61P25/28A61P3/02A61P31/00A61K47/30D01D5/00D01D5/08
Inventor DARCY, TREVOR JOHNGILBERT, STEVEN RAYGORDON, GREGORY CHARLESCHHABRA, RAJEEVALLEN, JR., WILLIAM MAXWELL
Owner THE PROCTER & GAMBLE COMPANY
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