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Composition of extract of emblica officinalis and method of preparing the same

a technology of emblica officinalis and extract, which is applied in the field of composition of emblica officinalis extract and the same, can solve the problems of affecting the ability of older individuals to recognize and understand the symptoms of early pathology. , to achieve the effect of improving the level of hdl-c, improving memory loss and dementia

Inactive Publication Date: 2012-05-03
ANTONY BENNY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022]Another object of the present invention is to provide a method of preparing a composition of the extracts of fruits of Emblica officinalis which has an application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss, dementia especially in Alzheimer's disease.
[0023]Yet other object of the invention is to provide a method of supplementing the composition to the patients with low HDL-C level, memory loss and dementia especially in patients with Alzheimer's disease giving therapeutically beneficial effect by increasing the level of HDL-C and improving the memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss, dementia especially in Alzheimer's disease.SUMMARY OF THE INVENTION
[0024]The present invention relates to a composition of the extract of fruits Emblica officinalis consisting of liquid juice of fruits of Emblica officinalis, a powder of an alcoholic extract of fruits of Emblica officinalis, a powder of a hydro alcoholic extract of fruits of Emblica officinalis, a powder of a water extract of fruits of Emblica officinalis, a powder of a juice of fruits of Emblica officinalis, a powder of dried fruits of Emblica officinalis, a powder of a water extract of dried fruits of Emblica officinalis, and, a powder of a pectinase treated water extract of fruits of Emblica officinalis, a method of preparing such compositions of extract of fruits of Emblica officinalis, more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss, dementia especially in Alzheimer's disease.

Problems solved by technology

These aging individuals expect to lead intellectually challenging lives in an environment rich with information and reliant on rapidly changing technologies.
Still, not every older individual with memory deficits progresses to AD dementia.
The vast number of people requiring constant care and other services can severely strain medical, monetary and human resources.
The extent and complexity of Alzheimer's disease that affects numerous cells, molecules, systems and pathways, impede attempts to determine which changes are specifically associated with early pathology.
Most of the clinical trials have returned negative results.
Nearly 50,000 research reports have been published on AD, yet we aren't anywhere near a disease-modifying treatment option which simultaneously addresses the various facets of the disease.
Current approaches and proposals address one single aspect and the disappointing results largely arise because of this basic flaw.
Various treatment options presently suggested and followed are without clear understanding of the disease process itself, and quite expectedly, all have failed at the clinic.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Method of Manufacture of a Powder of an Alcoholic Extract of Fruits of Emblica officinalis

[0046]Fresh fruits of Emblica officinalis (100 kilograms) having moisture 90% was pulverized and charged into an extractor. Around 200 liters of 95% methyl alcohol was pumped into the extractor and kept for a contact time of 3 hours. Then the solvent part was collected and fresh methyl alcohol pumped again into the extractor and extraction repeated thrice. All the extracts were pooled, filtered and dried in an Agitated thin film drier (ATM) which is working under vacuum 700 mm Mercury. Dried product (5 Kg) was discharged from the bottom of the vessel then pulverized and sieved through 30 mesh to obtain of powder of an alcoholic extract of fruits of Emblica officinalis.

The powder of the alcoholic extract of fruits of Emblica officinalis was found to have the following composition.

Polyphenol content: 70% (Titration method)

Hydrolysable gallo ellagictannins: 35% (HPTLC method)

example 2

Method of Manufacture of a Powder of a Hydroalcoholic Extract of Fruits of Emblica officinalis

[0047]Fresh fruits of Emblica officinalis 100 kgs was pulverized and charged into an extractor. Around 200 liters of methyl alcohol water mixture (70:30) was pumped into the extractor and kept for a contact time of 3 hrs. Then the solvent part collected and the fresh solvent pumped again into extractor and repeated thrice. All the extracts were pooled, filtered and concentrated in an Agitated thin film evaporator (ATFE) to TDS 30.0% (Total dissolved solids). Then the concentrate was fed into vacuum stripper and dried under vacuum at above 500 mm of mercury. Dried product (5 kg) is discharged from the bottom of the vessel, then pulverized and sieved through 30 meshes to obtain a powder of hydro alcoholic extract of fruits of Emblica officinalis.

The powder of the hydro alcoholic extract of fruits of Emblica officinalis was found to have the following composition.

Polyphenol content: 65% (Tit...

example 3

Method of Manufacture of a Powder of a Water Extract of Fruits of Emblica officinalis

[0048]Fresh fruits of Emblica officinalis 100 kgs was pulverized and charged into an extractor. Around 200 Liters of water was pumped into the extractor and kept for a contact time of 3 hrs. Then the solvent part was collected and the fresh solvent pumped again into extractor and repeated thrice. All the extracts were pooled, filtered and concentrated in an evaporator, when the concentrate reaches the bottom of the vessel; the concentrate is fed into drier and dried under vacuum above 500 mm of mercury. Dried product (6 Kg) was discharged from the bottom of the vessel, then pulverized and sieved through 30 mesh to obtain a powder of a water extract of fruits of Emblica officinalis.

The powder of the water extract of fruits of Emblica officinalis was found to have the following composition.

Polyphenol content: 60% (Titration method)

Hydrolysable gallo ellagic tannins: 25% (HPTLC method)

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Abstract

The present disclosure relates to a composition of an extract of fruits of Emblica officinalis selected from the group consisting of liquid juice of fruits of Emblica officinalis, a powder of an alcoholic extract of fruits of Emblica officinalis, a powder of a hydro alcoholic extract of fruits of Emblica officinalis, a powder of a water extract of fruits of Emblica officinalis, a powder of a juice of fruits of Emblica officinalis, a powder of dried fruits of Emblica officinalis, a powder of a water extract of dried fruits of Emblica officinalis, a powder of a pectinase treated water extract of fruits of Emblica officinalis, and combinations thereof; a method of preparing such compositions of extract of fruits of Emblica officinalis, more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss especially in Alzheimer's disease.

Description

FIELD OF THE INVENTION[0001]The present disclosure relates to a composition of the extract of fruits of Emblica officinalis, a method of preparing a composition consisting of extract of fruits of Emblica officinalis more particularly which has application as a nutraceutical or pharmaceutical for increasing HDL-C levels in patients with memory loss and dementia especially in patients with neurodegenerative diseases like Alzheimer's disease and for the treatment of memory loss, dementia especially in Alzheimer's disease.DESCRIPTION OF RELATED ART[0002]In our everyday life almost all the activities in one way or other deal with memory. Loss of memory means loss of one's self. Learning will make no sense if it is not retained by the individual. It is only through memory that we are able to relate different events, experiences, conditions, people, objects etc. Memory is needed in making social relationships, mastering cognitive competencies (mental capacities) and solving various problem...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/185A61P25/00A61P25/28A61P3/00
CPCA61K36/47A61K36/185A61P25/00A61P25/28A61P3/00
Inventor ANTONY, BENNY
Owner ANTONY BENNY
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