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Use of overground part of hedychium coronarium koenig in reducing blood glucose; extracts and compositions of overground part of hedychium coronarium koenig and their uses

a technology of hedychium coronarium and overground part, which is applied in the direction of biocide, drug composition, metabolic disorder, etc., can solve the problems of increasing the amount of insulin needed, and gradually losing the ability of the pancreas to produce insulin, so as to reduce the risk of diabetes, and increase the amount of insulin

Inactive Publication Date: 2011-08-11
DEV CENT FOR BIOTECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The invention further provides a method for making an extract of an overground part of Hedychium coronarium Koenig, and the extract prepared thereby which can be used to lower blood glucose, increase insulin levels, reduce insulin resistance and prevent and / or treat diabetes.

Problems solved by technology

Persistent or uncontrolled hyperglycemia is associated with increased and premature morbidity and mortality.
As a result, an increasing amount of insulin is needed, and the pancreas gradually loses its ability to produce insulin.
Treatment with these agents is successful in some cases, but the mortality index continues to rise.
Biguanides lower blood glucose levels by reducing intestinal glucose absorption and hepatic glucose; however, they do not stimulate insulin secretion.
The major side effects of biguanidine are lactic acidosis and increased cardiovascular mortality.
Alpha glucosidase inhibitors inhibit intestinal alpha glucosidases and consequently delay the digestion of sucrose and complex carbohydrates.
However, thiazolidinediones are only effective in the presence of insulin and may cause red blood cell abnormalities and headache.

Method used

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  • Use of overground part of hedychium coronarium koenig in reducing blood glucose; extracts and compositions of overground part of hedychium coronarium koenig and their uses
  • Use of overground part of hedychium coronarium koenig in reducing blood glucose; extracts and compositions of overground part of hedychium coronarium koenig and their uses
  • Use of overground part of hedychium coronarium koenig in reducing blood glucose; extracts and compositions of overground part of hedychium coronarium koenig and their uses

Examples

Experimental program
Comparison scheme
Effect test

example

Example 1

Glucose Tolerance Test of Ethanol Extract of Leaves and Pseudostem of Hedychium Coronarium in Normal Rats

[0039]26 Sprague-Dawley rats were divided into four groups: a placebo group (7 rats administered with 10% Tween 20), a positive control group (7 rats administered with glibenclamide), a 250 mg / kg HC group (6 rats administered with 250 mg / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium) and a 750 mg / kg HC group (6 rats administered with 750 mg / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium). The rats were fasted for 7 hours and were then administered with 250 mg / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium (250 mg / kg HC group), 750 mg / Kg ethanol extract of the leaves and pseudostem of Hedychium coronarium (750 mg / kg HC group), 10 mg / kg glibenclamide (positive control group) and 10% Tween 20 (placebo group). After 30 minutes, each rat received a total of 5 g / kg of glucose (glucose was administrated...

example 2

Glucose Tolerance Test of Ethanol Extract of Leaves and Pseudostem of Hedychium Coronarium in Mice with Type II Diabetes (Short-Term Postprandial Blood Glucose)

[0041]Twelve mice with type II diabetes (db+ / db+ mice) were fasted for 12 hours and then allowed to feed freely for two hours. Subsequently, the 6 mice of the control group were orally administered with 10% Tween 20 and the 6 mice of 1.5 g / kg HC group were orally administered with 1.5 g / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium. Blood was drawn at intervals of 0 minutes, 10 minutes, 30 minutes and 60 minutes after administering the ingredients for measurement of glucose (mg / DL). The results are shown in the table below and FIG. 2:

Concentration of blood glucose (mg / DL)Group0 min10 mins30 mins60 minsControl group; N = 6397.0 ± 12.6652.2 ± 25.5  645 ± 29.8536.3 ± 40.3HC group; N = 6396.8 ± 15.1534.3 ± 47.0440.2 ± 37.2**406.5 ± 38.8*The data is expressed with mean + / − standard error (SEM).P values ar...

example 3

Intraperitoneal Glucose Tolerance Test of Ethanol Extract of Leaves and Pseudostem of Hedychium Coronarium in Normal Mice

[0043]Eight mice (db− / db− mice) were divided into two groups: a control group (4 mice administered with 10% Tween 20) and a 1.5 g / kg HC group (4 mice administered with 1.5 g / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium). The mice were fasted for 14 hours and then allowed to feed freely for two hours. Subsequently, they were orally administered with 10% Tween 20 for the control group and 1.5 g / kg ethanol extract of the leaves and pseudostem of Hedychium coronarium for the 1.5 g / kg HC group. After 30 minutes, each mouse was intraperitoneally administered with 1.5 g / kg glucose. Blood was drawn at intervals of 0 minutes, 10 minutes, 30 minutes and 60 minutes for measurement of glucose (mg / DL). The results are shown in the table below and FIG. 3:

Concentration of blood glucose (mg / dl)Group0 min10 mins30 mins60 minsControl group130.8 + / − 20.7  ...

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Abstract

The present invention is related to the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels and treating and / or preventing diabetes without overly reducing blood glucose in a subject; i.e., not reducing blood glucose in a fasting subject. The present invention also relates to an extract and composition of the overground part of Hedychium coronarium Koenig and its use in lowering blood glucose, increasing insulin levels and treating and / or preventing diabetes.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority to U.S. Provisional application Ser. No. 12 / 701,997 filed Feb. 8, 2010; the disclosure of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention is related to the use of an herb in lowering blood glucose, increasing insulin levels and treating and / or preventing diabetes. Specifically, the invention provides the use of an overground part of Hedychium coronarium Koenig in lowering blood glucose, increasing insulin levels, and treating and / or preventing diabetes, and the extract and composition of the overground part of Hedychium coronarium Koenig and its use.BACKGROUND OF THE INVENTION[0003]Diabetes is a disease process resulting from multiple causative factors and is characterized by elevated levels of plasma glucose during the fasting state or after administration of glucose during an oral glucose tolerance test. Persistent or uncontrolled hyperglycemia i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/906A61P3/10
CPCA61K36/906A61P3/10A61K2236/13A61K2236/15A61K2236/17A61K2236/30A61K2236/53
Inventor WU, REY YUHWU, YU-YUANKUAN, LUNG-YUKING, KLIM
Owner DEV CENT FOR BIOTECHNOLOGY
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