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Stable hydroalcoholic compositions

a hydroalcoholic composition and stable technology, applied in the field of compositions, can solve the problems of reducing the surface tension, difficult to form stable viscous hydroalcoholic emulsions, and affecting the effect of hydroalcoholic compositions, so as to maintain or improve the natural barrier of the skin, and improve the skin condition

Inactive Publication Date: 2011-05-12
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a new composition that can be used as a skin disinfectant, such as for surgical hand preps and patient preps. The composition has a pleasant feel and is effective at killing bacteria, fungus, and viruses. It is made without using a polymeric thickener, which means it does not have a slimy feel. The composition can be dispensed as a lotion or foam. The invention also provides a method for preparing the stable hydroalcoholic composition by combining a thickener system with a hydroalcoholic solvent. The method involves heating the thickener system and combining it with an aqueous phase, followed by adding a lower chain alcohol to the mixture. The resulting composition has a unique texture and is effective at disinfecting skin.

Problems solved by technology

In addition, these formulated soaps may contain surfactants and possibly low levels of humectants such as glycerin.
Formulating stable viscous hydroalcoholic emulsions is difficult for two reasons.
First, addition of short chain alcohols (such as ethanol) to an aqueous system decreases the surface tension dramatically.
In bulletin 51-0001-259 regarding skin care, Specialty Chemicals of ICI America of Wilmington, Del. stated that although ethanol can provide several benefits to skin care emulsions, formulators often avoid ethanol as it is difficult to prepare stable emulsions in its presence.

Method used

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  • Stable hydroalcoholic compositions
  • Stable hydroalcoholic compositions
  • Stable hydroalcoholic compositions

Examples

Experimental program
Comparison scheme
Effect test

example 1

Alkyl Polyglucoside Thickener Systems

[0127]An alkyl polyglucoside emulsifier having an alkyl chain of 16 to 18 carbons was obtained as Montanov 68 from Seppic Inc. of Fairfield, N.J. This highly crystalline emulsifier was combined with other emulsifiers to form thickener systems in a hydroalcoholic solvent. The solvent was either 60:40 or 68:32 ethanol:water by weight. 200 proof ethanol and distilled water were used. The Montanov 68 / co-emulsifier ratio was varied keeping the total emulsifier concentration fixed at 5% by weight according to the following table:

Formulation (grams)EmulsifierABCDMontanov 6821.510.5Co-emulsifier0.51.01.52.060:40 ethanol:water47.547.547.547.5

[0128]Each co-emulsifier / Montanov 68 composition was prepared using the following procedure:[0129]1. The emulsifiers were heated above their melting temperature to 75° C.[0130]2. The hydroalcoholic solvent was heated to 75° C. in a sealed jar.[0131]3. The hot hydroalcoholic solvent was rapidly added to the molten emul...

example 2

Alkyl Polyglucoside / Brij 72 Optimization

[0136]A series of 15 formulations were prepared using a three component mixture design based on the results of Example 1. The following concentration ranges were investigated using a solvent ratio of 68:32 ethanol:water.

ComponentPercent by weightMontanov 680.26-3  Brij 721.0-5.2Solvent94-98

[0137]Each formulation was prepared and subsequently tested for stability and viscosity. The viscosities of the resulting formulations ranged from less than 50 cps to 93,600 cps. Stability results ranged from 0-83%. Examples of several optimized formulations appear below:

MontanovStability68Brij 72SolventViscosity(% volumeFormulaPercent by weight(cps)separation)A0.265.2094.5465,0003B3.003.009493,6000C2.202.9294.8872,0000D2.201.9295.8830,0000E1.802.7095.530,0000F3.202.3094.550,0000

[0138]These results together with those of Example 1 indicate that the viscosity of the formula for this thickener system is dependent upon the ratio of the emulsifiers. The results ...

example 3

Alkylpolyglucoside Ternary Thickener Systems

[0139]Based on the results obtained in Example 2, formulae E and F were chosen for use as base systems to which a third emulsifier was added to further increase the viscosity. The third emulsifier was added at concentrations of 0.3, 0.8, 1.3 and 1.8% by weight keeping the ratio of Montanov 68 and Brij 72 at the ratios found effective in formulations E and F of Example 2 according to the following table:

FormulaComponentABCDEFGHAmount (grams)Montanov 680.920.920.920.921.111.111.111.11Brij 721.371.371.371.371.551.551.551.55Coemulsifier0.150.400.650.900.150.400.650.90Solvent47.5747.3247.0746.8247.1946.9446.6946.44

[0140]The solvent used was 68:32 ethanol:water. The formulations were prepared and subsequently tested for stability and viscosity. The third co-emulsifiers used were behenyl alcohol (Lanette 22, Henkel Corp.) and stearamide diethanolamine (Lipamide S, Lipo Chemical of Paterson, N.J.). The following viscosity results were found:

VISCOS...

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Abstract

Disclosed is a composition including a lower alcohol and water in a weight ratio of about 35:65 to 100:0, between at least 0.5% and 8.0% by weight thickener system comprised of at least two emulsifiers, each emulsifier present in at least 0.05% by weight and wherein each emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The composition is useful as a presurgical scrub replacement, a lotion or other hand preparation.

Description

[0001]This application is a divisional of application Ser. No. 10 / 400,597, filed Mar. 27, 2003, which is a continuation of application Ser. No. 10 / 016,264 filed on 10 Dec. 2001 (U.S. Pat. No. 6,562,360), which is a divisional of application Ser. No. 09 / 320,590 filed on May 27, 1999 (U.S. Pat. No. 6,352,701), which is a continuation of application Ser. No. 08 / 781,090, filed on Jan. 9, 1997 (U.S. Pat. No. 5,951,993), which is a continuation-in-part of application Ser. No. 08 / 493,714, filed Jun. 22, 1995 (abandoned), all of which are incorporated herein by reference.FIELD OF THE INVENTION[0002]The present invention relates to compositions useful as skin disinfectants, surgical hand preparations, patient skin preparations and antimicrobial hand lotions. More specifically the invention relates to stable hydroalcoholic compositions which are thickened using mixed emulsifier systems.BACKGROUND OF THE INVENTION[0003]Control of nosocomial infection and exposure to infectious disease is of pa...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/12A01N25/00A61K9/08A01N25/30A01N31/02A01N31/08A01N37/52A01N59/12A61K8/00A61K8/06A61K8/20A61K8/34A61K8/37A61K8/39A61K8/40A61K8/41A61K8/46A61K8/60A61K8/86A61K8/92A61K31/045A61K31/70A61Q17/00A61Q19/00A61Q19/10C11D13/00
CPCA61K8/34Y10S514/946A61K8/37A61K8/39A61K8/416A61K8/604A61K8/86A61Q17/005A61Q19/00Y10S514/944Y10S514/975Y10S514/873Y10S514/846Y10S514/945A61K8/342A61P31/00A61P31/02
Inventor SCHOLZ, MATTHEW T.ASMUS, ROBERT A.CHARPENTIER, JILL R.
Owner 3M INNOVATIVE PROPERTIES CO
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