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Electrical Impedance Myography

Inactive Publication Date: 2010-11-18
NORTHEASTERN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]Existing techniques for assessing and diagnosing neuromuscular diseases can be unreliable, subjective and sometimes painful to the patient. Embodiments of the invention relate to methods and devices that can provide a reliable, quantitative and relatively painless assessment and diagnoses of neuromuscular diseases, and for assessment of disuse atrophy. Applicant has developed generally non-invasive techniques for characterizing muscle tissue, facilitating the assessment, diagnosis, monitoring and / or treatment of characteristics and / or conditions of muscle tissue that may be indicative of one or more neuromuscular disorders, including disuse atrophy.

Problems solved by technology

Existing techniques for assessing and diagnosing neuromuscular diseases can be unreliable, subjective and sometimes painful to the patient.

Method used

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Examples

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Embodiment Construction

[0024]Embodiments of the invention relate to methods and devices for determining a characteristic of a region of tissue by applying an electrical signal to the region and, in response to applying the electrical signal, obtaining an electrical measurement of the region of tissue. Such a technique may be referred to as electrical impedance myography (EIM). Neuromuscular disorders can be assessed and diagnosed based on the measured electrical signals. In some embodiments, the quantitative nature of the techniques described herein can facilitate the evaluation of the progress of a neuromuscular disorder. For example, the effectiveness of treatments for neuromuscular disorders, such as newly-developed drugs, may be evaluated using the techniques described herein.

[0025]To perform an EIM technique, an electrical signal (e.g., electric current) may be applied to the region of tissue using electrodes applied to the skin. Various characteristics can be determined based on the electrical param...

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Abstract

Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and / or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM.

Description

RELATED APPLICATIONS[0001]This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application Ser. No. 60 / 719,426, entitled “Method and Apparatus for Electrical Impedance Myography,” filed on Sep. 21, 2005, which is hereby incorporated by reference in its entirety.FEDERALLY SPONSORED RESEARCH[0002]This invention was made with Government support under Center for Integration of Medicine and Innovative Technology (CIMIT) grant number O7-33. The Government may have certain rights in this invention.BACKGROUND OF INVENTION[0003]Neuromuscular diseases encompass a large collection of disorders, ranging from relatively mild conditions such as focal compression neuropathies and nerve root injuries, to severe and life-threatening syndromes, including amyotrophic lateral sclerosis (ALS) and muscular dystrophies. These disorders may lead to muscle atrophy and weakness, caused either by injury to or disease of the neuron (neurogenic disorders), the neuromuscular junction, or ...

Claims

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Application Information

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IPC IPC(8): A61B5/053A61B5/296
CPCA61B5/0488A61B5/053A61B2562/046A61B2562/0209A61B5/0536A61B5/389A61B5/296A61B5/0531A61B2562/164
Inventor SHIFFMAN, CARL A.AARON, RONALDRUTKOVE, SEWARD B.
Owner NORTHEASTERN UNIV
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