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Guided bone regeneration membrane and manufacturing method thereof

a bone regeneration and membrane technology, applied in the field of guided bone regeneration membranes, can solve the problems of difficult to adopt this material difficult to handle these factors, and place a not-so-light burden on a patient, so as to improve the ability to adapt to an affected area, improve the ability to adapt to a large defect area, and improve the effect of cellular initial adhesion

Inactive Publication Date: 2010-05-13
NAGOYA INSTITUTE OF TECHNOLOGY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a new type of guided bone regeneration membrane which helps improve bone formation during dental procedures. The membrane consists of two layers: one made from polylactide (PLA), designed to protect against soft tissue infection, and another coated with apatite and silicon dioxide particles, which enhance attachment to cells and promote bone growth. The membrane also contains continuous pores allowing nutrients to reach cells. It is produced using a process called electrospinning, making it easier to fit into the patient's mouth without causing discomfort or pain. Overall, this innovative membrane offers better results than existing options and may become more widely used in dental practice.

Problems solved by technology

The technical problem addressed in this patent text is to develop a bioresorbable guided bone regeneration membrane that can promote bone regeneration and reconstruction more rapidly and reliably, by using a controlled release of silicon that genetically acts on cells to promote osteogenesis. This membrane should be effective in treating bone defects and should ideally be used in oral or maxillary surgery.

Method used

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  • Guided bone regeneration membrane and manufacturing method thereof
  • Guided bone regeneration membrane and manufacturing method thereof
  • Guided bone regeneration membrane and manufacturing method thereof

Examples

Experimental program
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first embodiment

[0020]According to a preferred embodiment of the present invention, such a guided bone regeneration membrane can be manufactured through the steps of electrospinning and soaking in a simulated body fluid (SBF). In the electrospinning step, a positive high voltage is applied to a polymer solution, and the resulting polymer solution is sprayed as fibers to a negatively charged collector.

[0021]A spinning solution for the formation of the PLA layer (PLA spinning solution) is prepared by dissolving a poly(lactic acid) in chloroform (CHCl3) or dichloromethane (DCM). The PLA spinning solution preferably has a poly (lactic acid) concentration of from 4 to 12 percent by weight for easy spinning. In this connection, the poly(lactic acid) generally has a molecular weight of from about 20×104 to about 30×104. For maintaining conditions for satisfactory spinning, the PLA spinning solution may further contain dimethylformamide (DMF) and / or methanol (CH3OH) in an amount up to about 50 percent by w...

examples

[0023]Manufacturing methods of guided bone regeneration membranes according to embodiments of the present invention will be illustrated with reference to several examples below. It should be noted, however, that these examples are included merely to aid in the understanding of the present invention and are not to be construed to limit the scope of the present invention.

[0024]Raw materials used in the examples are as follows.

[0025]Silicon-releasable calcium carbonate (Si—CaCO3): Vaterite having a silicon content of 2.9 percent by weight and prepared by using slaked lime (Microstar T; purity 96% or more; Yabashi Industries Co., Ltd., Japan), methanol (analytical grade reagent; purity 99.8% or more; Kishida Chemical Co., Ltd., Japan), γ-aminopropyltriethoxysilane (TSL 8331; purity 98% or more; GE Toshiba Silicones Co., Ltd., Japan), and carbon dioxide gas (high-purity liquefied carbon dioxide gas; purity 99.9%; Taiyo Kagaku Kogyo K.K.)

[0026]Poly(lactic acid) (PLA): PURASORB PL Poly(L-l...

example 2

[0035]A spinning solution having a PLA concentration of 9.0 percent by weight was prepared by blending 9 g of PLA and 91 g of CHCl3, and using this spinning solution, a PLA layer was prepared through electrospinning.

[0036][PLA Layer Preparation Conditions]

[0037]Spinning solution feed rate: 0.05 ml / min, applied voltage: 20 kV, distance between the nozzle and collector: 15 cm, nozzle: fixed, plate collector: fixed, spinning time: 60 minutes

[0038]Independently, PLA and Si—CaCO3 were kneaded in a heating kneader at 200° C. for 15 minutes to give a Si—CaCO3 / PLA composite containing 60 percent by weight of Si—CaCO3. A spinning solution having a Si—CaCO3 concentration of 13.0 percent by weight and a PLA concentration of 8.7 percent by weight was prepared by blending 25 g of the Si—CaCO3 / PLA composite and 90 g of CHCl3, and using this spinning solution, a Si—CaCO3 / PLA layer was prepared through electrospinning.

[0039][Si—CaCO3 / PLA Layer Preparation Conditions]

[0040]Spinning solution feed rat...

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Abstract

Disclosed is a guided bone regeneration membrane including a novel mechanism that effectively induces a bone reconstruction ability. The mechanism is provided by forming a bi-layered structure of a first nonwoven fabric layer containing a silicon-releasable calcium carbonate and a poly(lactic acid) as principal components and a second nonwoven fabric layer containing a poly(lactic acid) as a principal component; and coating the first nonwoven fabric layer with an apatite. The guided bone regeneration membrane is available by using a nonwoven fabric manufacturing technique through electrospinning and a simulated body fluid soaking technique.

Description

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Claims

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Application Information

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Owner NAGOYA INSTITUTE OF TECHNOLOGY
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