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Perfume Compositions

a technology of compositions and perfumes, applied in perfume formulations, disinfection, bandages, etc., can solve the problems of non-selective antimicrobial action, urine malodor is an age-old problem, unpleasant odour, etc., and achieve the effect of reducing ammonia production and highest efficacy

Inactive Publication Date: 2009-10-15
GIVAUDAN NEDERLAND SERVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0020]Perfumes constructed according to the above design provide effective urease inhibition without being overtly strongly antimicrobial (as indicated by tests described below) and also are able to counteract urine malodour olfactorily.

Problems solved by technology

The unpleasantness of urine malodour is an age-old problem.
Urease has the ability to rapidly break down urea (constituting about 2% of human urine) into ammonia causing unpleasant odour.
The use of common deodourant actives results in a non-selective antimicrobial action exerted upon most of the skin's natural microflora.
This can represent an undesirable feature of such deodourant formulations, since the natural microflora provides a protective barrier (colonisation resistance) against invasion by potentially pathogenic bacteria.
However, many of the deodourant perfumes disclosed in the art have relatively high odour intensities that are unsuitable for use in the sanitary or incontinence product sector, and / or are not effective in counteracting or inhibiting ammonia malodour.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

MIC Estimation for Fragrance and Fragrance Ingredients

[0077]The minimum inhibitory concentration of perfumes may be determined by the following method.

[0078]Stock solutions (8% w / w) of perfume were prepared in sterile tryptone soya broth.

Test Strain:

[0079]Proteus vulgaris NCTC 4175 (National Collection of Type Cultures, Public Health Laboratory Service, Central Public Health Laboratory, 61 Colindale Avenue, London)

[0080]Cultures were grown in 10 ml of tryptone soya broth (TSB) (Oxoid, Basingstoke, UK), for 16-24 hours, in shaken flasks at 37° C. The cultures were then diluted in sterile 0.1% special peptone solution (Oxoid, Basingstoke, UK) to give a concentration of bacteria of approximately 106 colony-forming units (cfu) per ml.

[0081]Test ingredients were diluted in sterile TSB. For each test bacterial culture, each row of a standard, 96-well plastic microtitre plate (labelled A-H) was allocated to one sample, thus eight samples per plate. Row H contained only TSB for use as a bac...

example 2

Urease Assay—Estimation of Fragrance and Fragrance Ingredients Effect on Ammonia Production

[0084]The method adopted was based on the rapid method devised by C. A. Stuart, Elizabeth van Stratum and Robert Rustigan Further Studies on Urease Production by Proteus and Related Organisms J. Bacteriol. 1945, 49: 437-444.

[0085]SSR Medium: 380 ml distilled water, 364 mg KH2PO4, 380 mg Na2HPO4, 8 g Urea, 40 mg Yeast extract, 20 ml 0.02% phenol red indicator, pH 6.8, solution filter sterilised. Culture: Liquid culture of P. vulgaris NCTC4175 was prepared by adding loops of fresh culture from solid media (Tryptone Soya Agar) to sterile 0.1% special peptone solution. Absorbance of culture was adjusted to be OD610 nm>2.3

[0086]Fragrances were aseptically prepared at 2500 ppm in medium in duplicate (5 ml volumes) using solubiliser Synperonic 91 / 10 at ratio of 1:2 fragrance: solubiliser. In addition 5 ml volumes of positive and negative controls were prepared. Positive controls and all test solution...

example 3

Perfume Compositions

[0087]Fragrance formulations 3.2, 3.4, and 3.8 detailed in Table 1 were created following the creative guidelines of the present invention. Formulations, 3.1, 3.3, 3.5, 3.6 and 3.7 are comparatives that fall outside these guidelines. All examples bar numbers 3.5 and 3.6 meet the Urease Inhibition Assay target of a difference of 1.2 pH units compared to the positive control. However only Formulations 3.2, 3.4 and 3.8 achieve this effect at sub-MIC level. These three perfumes were also evaluated in a urine malodour test as described in example 3 of PCT / GB2007 / 001172 using malodour model A of example 1 therein. All three were found to be effective in reducing the perception of the urine malodour.

TABLE 1Perfume Formulations (% w / w)Ingredient3.13.23.33.43.53.63.73.8Acetyl tributyl citrate101055Allyl amyl glycolate (A)13Amyl salicylate5547Anisic aldehyde (B)540.5Bangaloltm(G)0.30.3Benzyl acetate (A)1cis-3-hexenol (A)0.50.5cis-3-hexenyl salicylate1coumarex I modtm(B)5Cy...

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Abstract

Perfume compositions comprise between 10% and 30% in total by weight of perfume ingredients selected from two groups, Group A, Group B, with the provisos that over 5% but less than 15% of the perfume composition must comprise Group A ingredients, and for compositions comprising less than 10% of Group A ingredients the agregate percentage of Group B ingredients present must be at least equal to the expression 2* / 10-A%) where A% is the total percentage of Group A ingredients in the composition.

Description

FIELD OF THE INVENTION[0001]This invention relates to perfume compositions, to consumer products containing such perfume compositions, and to the use of such perfume compositions to provide deodourant effects including in particular inhibiting and ameliorating the odour of urine. The invention is particularly concerned with perfume compositions that inhibit the bacterial generation of ammonia from urea.BACKGROUND TO THE INVENTION[0002]The unpleasantness of urine malodour is an age-old problem. When urine is excreted into absorbent articles such as clothing, diapers or incontinence pads, or onto floors surrounding urinals or WC bowls, an ammoniacal malodour may often be detected within a short time. The same problem occurs in pet litter, and may of course be relevant anywhere in the house for households including cats or dogs, etc.[0003]Urine is a clear, transparent fluid that normally has an amber color, and when fresh is generally of low odour. The average amount of urine excreted ...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/49A61K8/35A61K8/33A61L9/01A61Q13/00
CPCC11B9/0061C11B9/0076C11B9/0084C11B9/0088A01K1/0152A61L15/46A61L9/01C11B9/0015C11B9/0019C11B9/003C11B9/0034C11B9/0038A61L2300/216A61L15/20
Inventor EVANS, GORDON MICHAELPROVAN, ALAN FORBESBRADSHAW, DAVID JONATHANBEHAN, JOHN MARTINPERRING, KEITH DOUGLAS
Owner GIVAUDAN NEDERLAND SERVICES
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