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Hemostatic Composition, Apparatus, and Methods

a composition and hemostatic technology, applied in the field of hemostatic composition, apparatus, and methods, can solve the problems of affecting the patient's recovery, affecting the recovery of patients, and many dressings with only modest anti-septic abilities, and achieve excellent and broad-spectrum hemostatic capabilities, high-effective hemostatic compositions, and concurrent anti-inflammatory properties

Inactive Publication Date: 2008-07-17
EASTWOOD LINDA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0003]The present invention provides improved compositions with antiseptic and properties. The invention encompasses the recognition that certain combinations of components of the flowers of pharmaceutical chamomile (Chamomilla recutita) and the leaves of dioecious nettle (Urtica dioica) produce highly effective hemostatic compositions. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with excellent and broad spectrum hemostatic capabilities, with concurrent antiseptic and anti-inflammatory properties.

Problems solved by technology

However, available compositions and dressings typically have only a modest hemostatic effect, so that bleeding continues for several (e.g., 2-3 minutes or more) after application of composition or dressing.
Additionally, many dressings have only modest antiseptic abilities.
Also, typical dressings are prepared from materials that have a tendency to adhere to the injured surface, causing significant pain to the patient when the dressing is applied or removed.
Because of the modest hemostatic and / or antiseptic activity, standard dressings often need to be changed frequently, further exacerbating adhesion problems.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of an Inventive Chamomile / Nettle / Alginate Hemostatic Composition

[0044]The present Example describes preparation of an exemplary chamomile / nettle / alginate hemostatic composition according to the present invention.

[0045]3.55 g of pharmaceutical chamomile flowers and 1.3 g of dioecious nettle leaves are ground in a mill to a powdery consistency. 200 ml of hot, distilled water are poured over the mixture, and it is boiled for 15 minutes. The mixture is then cooled to a temperature of 40° C. and filtered. The volume of the herbal extract thus obtained is then reduced to 200 ml. 8.3 g of an alginate of sodium is added, and the mixture is maintained at room temperature for 12 hours, with occasional stirring.

example 2

Layered Textile

[0046]The present Example describes preparation of a layered textile in which a chamomile / nettle / alginate composition prepared according to Example 1 is layered on a textile material. The resulting layered textile has long-acting high hemostatic and antiseptic properties, is atraumatic, and displays good sanitary and hygenic properties.

[0047]A chamomile / nettle / alginate composition prepared according to Example 1 is evenly applied onto an 80×80 cm layer of non-woven material made of a combination of viscose and cotton fibers stitched with reinforcing thread in rows spaced in 4 mm intervals, so that 120 g of composition are applied per square meter of material. The resulting layered textile is air-dried, cut into 6×10 cm or 10×18 cm pads, packed into paper envelopes laminated in polyethylene, and subjected to sterilization by radiation at a dosage of no more than 15 kiloherz.

[0048]Application of the layered textile prepared according to this Example as a wound dressing ...

example 3

Treatment of Wounds with Inventive Layered Textile Dressing

[0050]The present Example describes use of an inventive layered textile dressing in the treatment of patients in body cavity operations, parenchymatous bleeding contexts, or other surgical procedures.

[0051]Inventive layered textile dressings prepared according to Example 2 were tested for their hemostatic quality in the surgical division of the Russian State Medical University (RGMU). Pads (60×10 cm or 10×18 cm) were applied as a local hemostatic medium to halt bleeding from small vessels. 30 patients who had undergone body cavity operations or other surgical procedures, or who suffered from parenchymatous bleeding were treated. Pads were applied to the surface of a wound for 30-40 seconds, and resulting in the halting of the bleeding. No side effects in the application of pads were observed.

[0052]Additional clinical testing of inventive layered textile dressing has been performed at the I.M. Sechenov Moscow Medical Academy ...

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Abstract

The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita) and the leaves of dioecious nettle (Urtica dioica). Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with excellent and broad spectrum hemostatic capabilities, with concurrent antiseptic and anti-inflammatory properties. The invention further provides methods of using the inventive compositions in to reduce or stop bleeding, as well as a variety of apparatuses useful in hemostatic contexts that incorporate the inventive compositions. In one particular embodiment, the invention provides hemostatic dressings in which a polymeric layer incorporating chamomile and nettle components is applied to a textile or fabric material, for example a non-woven viscose.

Description

BACKGROUND[0001]A wide variety of compositions and devices have been developed for use in controlling bleeding. However, available compositions and dressings typically have only a modest hemostatic effect, so that bleeding continues for several (e.g., 2-3 minutes or more) after application of composition or dressing. Additionally, many dressings have only modest antiseptic abilities. Also, typical dressings are prepared from materials that have a tendency to adhere to the injured surface, causing significant pain to the patient when the dressing is applied or removed. Because of the modest hemostatic and / or antiseptic activity, standard dressings often need to be changed frequently, further exacerbating adhesion problems.[0002]There remains a need for the development of improved hemostatic compositions, methods, and devices.SUMMARY OF THE INVENTION[0003]The present invention provides improved compositions with antiseptic and properties. The invention encompasses the recognition that...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K36/185A61L15/40A61P17/02
CPCA61K31/722A61K36/185A61K36/28A61K45/06A61L15/40A61L2400/04A61F13/00A61K2300/00A61P7/04A61P17/02
Inventor OLTARZHEVSKAYA, NATALIE DMITRIEVNASAVILOVA, LARISA BORISOVNAKRICHEVSKY, GERMAN EVSEEVICH
Owner EASTWOOD LINDA
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