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Packaging solutions

a technology for ophthalmic devices and packaging solutions, applied in the direction of packaging sterilisation, transportation and packaging, rigid containers, etc., can solve the problems of reducing shelf life and/or adverse reactions, limited use of surfactants in packaging solutions, and many people wearing contact lenses still experience dryness or eye irritation, etc., to achieve uniform coating of anionic polymer, preserve the sterility of solution and ophthalmic devi

Inactive Publication Date: 2008-06-26
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for preparing a package of a storable, sterile ophthalmic device by immersing the device in an aqueous packaging solution containing an anionic polymer and a non-ionic polyol, and heat sterilizing the solution. The solution has an osmolality of at least about 200 mOsm / kg and a pH of about 6 to about 9. The invention also provides a packaging system for storing the ophthalmic device in a sealed container containing the device immersed in the aqueous packaging solution. The technical effects of the invention include improved comfort for the wearer, extended wear of the lens without irritation or other adverse effects to the cornea, and better preservation of the sterility of the solution and device.

Problems solved by technology

Furthermore, the difficulties of adding a surfactant to a packaging solution, including the possibility of lowering shelf-life and / or adverse reactions during heat sterilization, have further limited the use of surfactants in a packaging solution for the purpose of providing any possible or marginal effect on lens comfort.
Nevertheless, many people who wear contact lenses still experience dryness or eye irritation throughout the day and particularly towards the end of the day.
An insufficiently wetted lens at any point in time will cause significant discomfort to the lens wearer.
This type of polyanion may not coat uniformly a surface of a contact lens, resulting in the lens being relatively uncomfortable during use.

Method used

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Examples

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example 1

[0070]A clean hilafilcon A lens, which is a copolymer composed mainly of HEMA and NVP, was soaked in a lens packaging solution within the scope of the present invention overnight and autoclaved for 30 minutes at 121° C. The ingredients and amounts of the solution are set forth in Table 2. The carboxymethylcellulose was a medium viscosity (MV) grade (viscosity no greater than 30 cp). The XPS results for the lens are set forth below in Table 4.

TABLE 2Ingredients% w / wSodium borate0.215Boric acid1.000Ethylenediaminetetraacetic0.050acid (EDTA)Carboxymethylcellulose1.000(MV)Glycerin1.000pH = 7.16Osmolality = 347 mOsm / kg

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Abstract

The present invention is directed to new and improved packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with aqueous packaging solutions to improve the comfort of the lens during wear. In particular, the present invention is directed to a packaging system for storing an ophthalmic device in an aqueous packaging solution comprising an anionic polymer and a non-ionic polyol. Such solutions can be retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.

Description

BACKGROUND OF THE INVENTION[0001]1. Technical Field[0002]The present invention generally relates to packaging solutions for ophthalmic devices such as contact lenses.[0003]2. Description of Related Art[0004]Blister-packs and glass vials are typically used to individually package each soft contact lens for sale to a customer. Saline or deionized water is commonly used to store the lens in the blister-packs, as mentioned in various patents related to the packaging or manufacturing of contact lenses. Because lens material may tend to stick to itself and to the lens package, packaging solutions for blister-packs have sometimes been formulated to reduce or eliminate lens folding and sticking. For this reason, poly(vinyl alcohol) (PVA) has been used in contact lens packaging solutions.[0005]It has been stated that if a lens is thoroughly cleaned before insertion, lacrimal fluid can adequately wet the lens. Furthermore, the difficulties of adding a surfactant to a packaging solution, inclu...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B65B55/22B65B55/12B65B55/14B65D85/00
CPCA45C11/005A61L12/08B65B25/008A61L12/147A61L12/14
Inventor XIA, ERNINGHOOK, DANIEL J.SALAMONE, JOSEPH C.
Owner BAUSCH & LOMB INC
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