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FT-0554 substance and its production

a technology of ft-0554 and substance, which is applied in the direction of biocide, antiparasitic agents, drug compositions, etc., can solve the problem of large economic burden of parasitosis

Inactive Publication Date: 2002-10-24
THE KITASATO INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0061] As explained hereinabove, FT-0554 substance of the present invention is expected to be a satisfactory and useful medicament for treatment of parasitosis.

Problems solved by technology

Recently, however, the import parasitosis, zoonotic parasitosis, opportunistic parasitosis and parasitosis originated from perishable foods are prevailing and become crucial problems, Further the parasitosis produces large economical burdens in the stock-farming and agriculture.

Method used

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  • FT-0554 substance and its production
  • FT-0554 substance and its production
  • FT-0554 substance and its production

Examples

Experimental program
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Effect test

example

[0058] A loopful of Aspergillus niger FT-0554 (FERM BP-6443) cultured in agar slant medium was inoculated into the liquid medium (pH 7.0) containing glucose 2.0%, polypeptone (Nihon Seiyaku Co.) 0.5%, agar 0.1%, yeast extract (Oriental Yeast Co.) 0.2%, magnesium sulfate 7 hydrate 0.05% and pottassium dihydrogen phosphate 0.1% dissolved in 50% natural seawater (salt concentration 3.4% natural seawater was used) and divided into 100 ml in a 500 ml Erlenmeyer flask, and shake cultured at 27.degree. C. for 2 days.

[0059] This seed culture liquid each 1 ml was inoculated into the liquid medium containing potato dextrose broth (Difco Inc.) 2.4% dissolved in 50% natural seawater (salt concentration 3.4% natural seawater was used) divided each 100 ml in a 500 ml Erlenmeyer flask (.times.30 flasks) and shake cultured at 27.degree. C. for 96 hours.

[0060] Cultured liquid medium was centrifuged and obtained mycelia was extracted with ethanol 3 lit. Ethanol was removed in vacuo. Mycelia was again...

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Abstract

The present invention is to obtain novel FT-0554 substance which is useful for treatment of helminthiasis. The present invention comprising the steps of culturing the microorganism belonging to fungi having producing activity of FT-0554 substance represented by the following formula [I] subjected to accumulation of FT-0554 substance in the cultured medium, and isolating FT-0554 substance from the said cultured mass. The medicament useful for treatment of parasitic infection, specifically helminthiasis can be obtained.

Description

[0001] This invention relates to novel FT-0554 substance useful for treatment for infection of parasite, especially helminth, and its production.PRIOR ARTS[0002] Parasitosis is reducing as a result of improvement in sanitary conditions and progress of anthelmintics. Recently, however, the import parasitosis, zoonotic parasitosis, opportunistic parasitosis and parasitosis originated from perishable foods are prevailing and become crucial problems, Further the parasitosis produces large economical burdens in the stock-farming and agriculture. For infection of helminth in the parasite, at present, avermectins, mebendazole, praziquantel, and others are used for treatment of helminth.PROBLEMS TO BE SOLVED BY THE INVENTION[0003] Anthelmintics used at present, such as avermectins, mebendazole and praziquantel, are not always sufficient for satisfactory in usefulness and toxicity, and the anthelmintics, which can solve these problems, are strongly, required.[0004] Consequently, the present ...

Claims

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Application Information

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IPC IPC(8): C07D493/04C12P17/18
CPCC07D493/04C12P17/181C12P17/18A61P33/00A61P33/10
Inventor OMURA, SATOSHISHIOMI, KAZUROMASUMA, ROKUROIWAI, YUZURU
Owner THE KITASATO INST
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