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Non-contact acoustic radiation force based (ARF-based) generation of broad bandwidth mechanical waves using air-coupled ultrasound

a technology of acoustic radiation force and broad bandwidth, applied in the direction of instruments, applications, ultrasonic/sonic/infrasonic image/data processing, etc., can solve the problem of not measuring the elastic properties of soft tissue sufficiently for diagnostic purposes

Active Publication Date: 2022-08-16
UNIV OF WASHINGTON
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Benefits of technology

The patent describes methods and systems for measuring the elastic properties of soft materials using an acoustic radiation force. This force is applied by reflecting ultrasound from an interface boundary between the soft material and air, resulting in a mechanical wave without directly contacting the soft material. The methods and systems are suitable for use in applications where a non-contact dynamic elastography approach is desirable, such as for use in a patient's cornea. The resulting propagating wave approximates a plane wave, simplifying the determination of the elastic properties from the observed propagation of the mechanical wave.

Problems solved by technology

Existing non-contact systems for generation / detection of a mechanical wave in a soft tissue, however, may fail to measure elastic properties of the soft tissue sufficiently for diagnostic purposes.

Method used

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  • Non-contact acoustic radiation force based (ARF-based) generation of broad bandwidth mechanical waves using air-coupled ultrasound
  • Non-contact acoustic radiation force based (ARF-based) generation of broad bandwidth mechanical waves using air-coupled ultrasound
  • Non-contact acoustic radiation force based (ARF-based) generation of broad bandwidth mechanical waves using air-coupled ultrasound

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Embodiment Construction

[0040]In the following description, various embodiments of the present invention will be described. For purposes of explanation, specific configurations and details are set forth in order to provide a thorough understanding of the embodiments. It will, however, also be apparent to one skilled in the art that the present invention may be practiced without the specific details. Furthermore, well-known features may be omitted or simplified in order not to obscure the embodiment being described.

[0041]Methods and systems are described herein for dynamic elastography using non-contact mechanical stimulation of a soft material (i.e., a material having an elastic modulus in a range of 1 Pa to 1 MPa) via the application of an air-coupled ultrasound pulse to induce significant transient mechanical displacement at the boundary of a soft material using reflection-based radiation force. The induced transient mechanical displacement generates a mechanical wave that propagate through the soft mate...

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Abstract

Methods and systems for measuring one or more properties of a soft material employ air transmitted ultrasound that is reflected from the soft material to generate a mechanical wave in the soft material. A method of measuring one or more properties of a soft material includes transmitting ultrasound through air to an interface boundary between the soft material and air. Force is applied to the soft material by reflecting the ultrasound from the soft material. A mechanical wave is generated in the soft material as a result of the force applied to the soft material. Propagation of the mechanical wave in the soft material is measured with an imaging system. One or more properties of the soft material is determined based on the measured propagation of the mechanical wave in the soft material.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]The present application is a U.S. 371 of International Application No. PCT / US2017 / 034801, filed May 26, 2017, which claims the benefit of U.S. Provisional Application No. 62 / 341,775, filed May 26, 2016 and U.S. Provisional Application No. 62 / 413,563, filed Oct. 27, 2016, the entire contents of which are hereby incorporated by reference in their entirety for all purposes.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT[0002]This invention was made with government support under Grant No. R01EY026532, awarded by the National Institutes of Health. The government has certain rights in the invention.BACKGROUND[0003]The stiffness of a soft tissue can be clinically valuable information with respect to diagnosis of disease, especially when combined with conventional medical imaging. Elastography is the term applied to the mapping of the elastic properties of a soft tissue. Different elastography techniq...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61B8/14A61B8/10A61B3/10A61B3/16A61B8/08A61B8/00
CPCA61B8/10A61B3/102A61B3/16A61B8/0858A61B8/4444A61B8/4488A61B8/485G01N29/26A61B5/0051A61B5/0066A61B5/442G01N29/0654G01N29/221G01N29/2456G10K11/26G01N2291/02475
Inventor AMBROZINSKI, LUKASZO'DONNELL, MATTHEWPELIVANOV, IVANYOON, SOON JOONLI, DAVIDSONG, SHAOZHENWANG, RUIKANG K.SHEN, TUENG T.GAO, LIANG
Owner UNIV OF WASHINGTON
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