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Composition of ambroxol, salt thereof and anti-infective drug

A composition and anti-infection technology, applied in the field of medicine, to achieve the effects of wide application prospects, uniform and stable drug quality, and stable indicators

Inactive Publication Date: 2007-07-04
JIANGSU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented formulation contains two components - an antimicrobial agent called Ambrolox with either amantadine hydroxyzone or other drugs like salbutamol – which can treat various diseases such as sinus inflammations associated with bacteria lung abscesses. It also includes different types of agents used together to make it more effective than each alone. Overall, this new formula provides technical benefits over existing compositions while maintaining their efficacy against these conditions.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways to improve treatment against various types of disease like infectious agents causing respiration disorders due to airborne brands called Actinosides, especially those containing beta glutenone dihydocyrate (a type of steroid), while also addressing issues related to these compounds.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] The preparation of embodiment 1 ammonium yellow composition common tablet

[0107] 1. Prescription:

[0108] Ambroxol Hydrochloride 15g

[0109] Baicalin 250g

[0110] Starch 60.0g

[0111] Microcrystalline Cellulose 20.0g

[0112] 2% HPMC aqueous solution appropriate amount

[0113] Magnesium Stearate 1.0g

[0114] Sodium starch glycolate 2.0g

[0115] A total of 1000 tablets were prepared

[0116] 2. Specific steps:

[0117] Ambroxol hydrochloride and baicalin were pulverized through a 100-mesh sieve for subsequent use. The raw materials and auxiliary materials are weighed according to the prescription amount, and the hypromellose is dissolved in water to prepare a 2% aqueous solution for subsequent use. Mix ambroxol hydrochloride, baicalin, starch, and microcrystalline cellulose evenly, add an appropriate amount of 2% HPMC aqueous solution, and stir evenly to make a suitable soft material, pass through a 20-mesh sieve ...

Embodiment 2

[0118] Example 2 Preparation of Ammonia Composition Film-Coated Tablets

[0119] 1. Prescription:

[0120] Ambroxol Hydrochloride 30g

[0121] Yanhuning 40g

[0122] Starch 50.0g

[0123] Microcrystalline Cellulose 40.0g

[0124] 2% HPMC aqueous solution appropriate amount

[0125] Magnesium Stearate 2.0g

[0126] Low-substituted hydroxypropyl cellulose 10.0g

[0127] A total of 1000 tablets were prepared

[0128] 2. Specific steps:

[0129] Grind the ambroxol hydrochloride and Yanhuning through a 100-mesh sieve for later use. The raw materials and auxiliary materials are weighed according to the prescription amount, and the hypromellose is dissolved in water to prepare a 2% aqueous solution for subsequent use. Mix ambroxol hydrochloride, Yanhuning, starch, and microcrystalline cellulose evenly, add an appropriate amount of 2% HPMC aqueous solution, stir evenly, and make a suitable soft material, pass through a 20-mesh sieve to ...

Embodiment 3

[0130] Embodiment 3 Preparation of ammonia yellow composition, ammonia inflammation composition capsule

[0131] 1. Prescription:

[0132] Ammonia Composition Prescription

[0133] Ambroxol Hydrochloride 30g

[0134] Baicalin 250g

[0135] Starch 40.0g

[0136] Microcrystalline Cellulose 20.0g

[0137] 2% HPMC aqueous solution appropriate amount

[0138] Magnesium Stearate 2.0g

[0139] A total of 1000 capsules were prepared

[0140] Ammonia Composition Prescription

[0141] Ambroxol Hydrochloride 30g

[0142] Yanhuning 20g

[0143] Starch 40.0g

[0144] Microcrystalline Cellulose 20.0g

[0145] 2% HPMC aqueous solution appropriate amount

[0146] Magnesium Stearate 2.0g

[0147] A total of 1000 capsules were prepared

[0148] 2. Specific steps:

[0149] Ambroxol hydrochloride and baicalin (or Yanhuning) are pulverized through a 100-mesh sieve for later use. The raw materials and auxiliary ma...

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Abstract

The invention belongs to the field of medical technology, and discloses a medicinal combination which contains ambroxol or its pharmaceutical acceptable salt and at least one anti-infective drug and their preparation methods and uses. Among them, the anti-infective drugs selected from: baicalin and/or 14-dehydroxylation-11, 12-two-dehydrogenating-andrographolide-3, 19-two succinic acid half ester salt, the drug combinations can be made to various pharmaceutical acceptable formulations; combinations are used to preparing and treating upper respiratory tract infection, chronic bronchitis, pneumonia and exfoliative viscous, expectoration difficulty and other disease leading by upper respiratory tract infection(such as acute, chronic bronchitis, bronchial asthma, bronchiectasis and phthisis confirmata and so on), and has synergic synergism and the stability is fine, its effect is improved greatly compared to only using same dosage alcaine ambroxol or baicalin or Yanhuning, it produces unexpected results and has extensive application prospects.

Description

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Claims

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Application Information

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Owner JIANGSU UNIV OF TECH
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