Blackberry lily isoflavone compound and its application in medical field
A kind of compound and isoflavone technology, applied in the fields of natural medicinal chemistry and medical technology
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Embodiment 1
[0016] Embodiment 1 The preparation method of Shegan total isoflavones
[0017]Shoot dry 10Kg of medicinal materials, heat extract three times with 10 times the amount of 95% ethanol, each extraction time is 100 minutes, filter, and recover the ethanol from the filtrate under reduced pressure, add water to dilute to 10 times the volume, and apply the treated AB-8 macroporous resin Column, first eluted 5 column bed volumes with water, then eluted 5 column bed volumes with 90% ethanol, collected the 90% ethanol part of the eluate, recovered ethanol under reduced pressure, concentrated and dried, and obtained 198 g of total isoflavones (Yield 2.5%). After testing, the content of isoflavones in the extract is 91%. The obtained total isoflavones are separated by silica gel, gel and other column chromatography to obtain the above 19 isoflavones. Their chemical structures were determined by spectroscopic analysis and comparison with the literature. Among them, the specific separat...
Embodiment 2
[0019] Example 2 Experiment of the effect of Shegan total isoflavones on the estrogen level in rats
[0020] 2.1 Purpose of the experiment: To study the effect of gavage administration of total isoflavones of Shegan on estrogen in female castrated rats, and plan to use it for the treatment of female menopausal syndrome in the future.
[0021] 2.2 Experimental materials:
[0022] 2.2.1 Shegan total isoflavones: self-made.
[0023] 2.2.2 Soybean Isoflavones: Handan Mailang Plant Extraction Co., Ltd., batch number: 20040412
[0024] 2.2.3 Penicillin sodium for injection: Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., batch number: 05019321
[0025] 2.2.4 0.9% normal saline: Shanghai Huayuan Changfu Pharmaceutical (Group) Co., Ltd., batch number: 05112503
[0026] 2.3 Dosage: The solvent group was given normal saline, and the dry total isoflavones were divided into three dosage groups (300mg / kg, 600mg / kg and 900mg / kg), and the positive control used soybean isoflavones 1000mg...
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