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Preparing method of gentian capsule for purging liver fire

A technology of capsule preparation and gentian purging liver, which is applied in the field of medicine and medical engineering, can solve the problems of poor stability, difficulty in dissolving, easy to absorb moisture and deteriorate, and achieve the effect of easy to dissolve, not easy to absorb moisture, and enhance stability

Inactive Publication Date: 2007-06-27
文永盛 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The existing problems in the preparation of Longdan Xiegan Capsules are: easy to absorb moisture and deteriorate, poor stability, difficult to dissolve

Method used

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  • Preparing method of gentian capsule for purging liver fire

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with preferred embodiments.

[0028] According to the State Food and Drug Administration Standard (Trial) YBZ06152005 Longdan Xiegan Capsules

[0029] [Prescription] Gentian 120g Bupleurum 120g Scutellaria baicalensis 60g Gardenia (fried) 60g

[0030] Alisma 120g Akebia 60g Plantago Seed (stir-fried with salt) 60g Angelica (stir-fried with wine) 60g

[0031] Rehmannia glutinosa 120g Licorice (honey roasted) 60g

[0032] The preparation method steps are as follows:

[0033] (1) Weigh 10 medicinal materials according to the proportion of the drug prescription, add 8 times the amount of water to decoct twice for 1.5 hours each time, filter, combine the filtrate, and concentrate the filtrate to a clear paste with a relative density of 1.25-1.28 (80°C) . This step is the best decocting scheme screened by the orthogonal experiment (the active ingredient is counted as gentiopicroside, and the transfer rat...

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Abstract

The preparation process of gentian capsule for purging liver fire with ten kinds of Chinese medicinal materials, including gentian, bupleurum root, skullcap root, cape jasmine, oriental water plantain, etc. includes the following steps: twice decoction for 1.5 hr each, filtering, merging the filtrate, concentrating to density of 1.25-1.28, adding alcohol to alcohol content of 70 %, standing for over 24 hr, filtering and recovering alcohol from the filtrate, adding dextrin to density of 1.18, spray drying to obtain extractum powder, mixing with dextrin, pelletizing, low temperature drying and encapsulating. The gentian capsule has less moisture absorption and high stability.

Description

technical field [0001] The invention relates to the fields of medicine and medical engineering, in particular to a preparation method of Longdan Xiegan capsules. Background technique [0002] For the preparation of Longdan Xiegan Capsules, granulation is the key technology in the preparation of dosage forms. The current industrial granulation methods can be divided into: extrusion granulation, wet mixing granulation, fluidized spray granulation, spray drying granulation, etc. Several types, fluidized spray granulation and spray drying granulation are mostly used for the preparation of capsule particles. See the 21st Century Higher Vocational and Technical Textbook "Pharmacology of Traditional Chinese Medicine", edited by Liu Hanqing of Nanjing University of Traditional Chinese Medicine and Ni Jian of Beijing University of Traditional Chinese Medicine, published by Science Press. The existing problems in the preparation of Longdan Xiegan Capsules are: easy to absorb moisture...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61K9/48A61P1/16
Inventor 文永盛
Owner 文永盛
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