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Metronidazole ethanolamine spray as blood flukedisease preventing and treating medicine for farm cattle and its preparing method

A technology for niclosamide ethanolamine salt and schistosomiasis, which is applied in the field of drug protective agent to prevent schistosomiasis infection of farm cattle, can solve the problems of lack of prevention and control methods for farm cattle infection with schistosomiasis, and achieves prevention of schistosomiasis infection, promotion of production and control of infection source effect

Inactive Publication Date: 2007-06-27
JIANGSU INST OF PARASITIC DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cattle are the most important source of infection for schistosomiasis. At present, there is still a lack of effective prevention and treatment methods to control the infection of schistosomiasis in cattle. It is difficult to implement measures such as replacing cattle with machines and prohibiting grazing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: the preparation of niclosamide ethanolamine salt spray

[0011] In terms of mass percentage, 5 parts of niclosamide ethanolamine salt is dissolved in 10 parts of ethylenediamine, 2 parts of azone and 1 part of Span 60 are added, stirred and added to 82 parts of absolute ethanol to obtain niclosamide Ethanolamine salt spray.

Embodiment 2

[0012] Embodiment 2: the preparation of niclosamide ethanolamine salt spray

[0013] In terms of mass percentage, 5 parts of niclosamide ethanolamine salt is dissolved in 5 parts of ethylenediamine, 2 parts of azone and 2 parts of Span 60 are added, and stirred into 86 parts of absolute ethanol to obtain niclosamide Salidamide salt spray.

Embodiment 3

[0014] Embodiment 3: the preparation of niclosamide ethanolamine salt spray

[0015] In terms of mass percentage, 0.5 parts of niclosamide ethanolamine salt is dissolved in 10 parts of dimethyl sulfoxide, 0.5 parts of azone and 1 part of Span 60 are added, stirred and added to 88 parts of absolute ethanol to obtain niclosamide Amine ethanolamine salt spray.

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PUM

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Abstract

The present invention is niclosamide ethanolamine spray as blood fluke disease preventing and treat medicine for farm cattle and its preparation process. The present invention prepares the niclosamide ethanolamine spray through dissolving niclosamide ethanolamine in 0.5-5 weight portions in cosolvent in 5-10 weight portions, adding penetant in 0.5-2 weight portions and emulsifier in 1-5 weight portions, adding anhydrous alcohol via stirring to 100 weight portions and obtain the niclosamide ethanolamine spray. The niclosamide ethanolamine spray is sprayed to the skin of farm cattle to form one lipophilic protecting medicine layer capable of preventing farm cattle against blood fluke disease in 15-30 days.

Description

technical field [0001] The invention discloses a cattle schistosomiasis protective agent-niclosamide ethanolamine salt spray and a preparation method thereof, belonging to the technical field of drug protective agents preventing cattle from being infected with schistosomiasis. Background technique [0002] Schistosomiasis japonicum is a major infectious disease that seriously endangers the health of our people, and it is a zoonotic disease. Cattle are the main source of infection of schistosomiasis. At present, there is still no effective control method to control the infection of schistosomiasis in cattle. It is difficult to implement measures such as replacing cattle with machines and prohibiting grazing. The technology of cattle schistosomiasis protective agent is to use niclosamide ethanolamine salt with high efficiency, low toxicity and low price, which has a good effect of killing schistosomiasis cercariae, and dissolve it in a co-solvent to make a spray, which is spra...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/4985A61K9/12A61P33/12
Inventor 戴建荣
Owner JIANGSU INST OF PARASITIC DISEASES
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