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Preparing process of botanical hollow enteric hard capsule

The technology of a hollow hard capsule and a production method is applied in the directions of capsule delivery, drug delivery, pharmaceutical formulation, etc., which can solve problems such as the limitation of gelatin capsules, and achieve the effects of ensuring enteric solubility, good toughness, and not easy to mold and deteriorate.

Inactive Publication Date: 2007-06-27
黄族和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Undoubtedly, gelatin capsules will be greatly limited in the future.

Method used

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Examples

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Embodiment 1

[0031] Embodiment 1, a method for preparing a plant-based enteric-coated hollow hard capsule of the present invention, a method for preparing a plant-based enteric-coated hollow hard capsule, comprising the following steps;

[0032] Step a. Glue making: use wet kelp or sargassum, add sodium carbonate, and prepare food-grade or pharmaceutical-grade powdered or granular sodium alginate at an ambient temperature of 60°C; the viscosity of the sodium alginate is 15 centipoise, PH value 6.5, transparency 7 cm, fineness 80 mesh;

[0033] Step b. Sol: Pour powdery or granular sodium alginate into a stainless steel container, add pure soft water five times the weight of sodium alginate to dissolve sodium alginate to make a glue;

[0034] Step c. Defoaming: place the container containing the glue in a water bath, and remove the bubbles by heating to boiling;

[0035] Step d. Glue dipping: Use a metal mold to dip into the glue solution at room temperature. After each mold is evenly coat...

Embodiment 2

[0046] Embodiment 2, a manufacturing method of a plant-based enteric-coated hollow hard capsule of the present invention, a manufacturing method of a plant-based enteric-coated hollow hard capsule, which comprises the following steps;

[0047] Step a. Glue making: use wet kelp or sargassum, add sodium carbonate, and prepare food-grade or pharmaceutical-grade powdery or granular sodium alginate at an ambient temperature of 65°C; the viscosity of the sodium alginate is 25 centipoise, PH value 7.5, transparency 10 cm, fineness 100 mesh;

[0048] Step b. Sol: Pour powdery or granular sodium alginate into a stainless steel container, add pure soft water 7 times the weight of sodium alginate to dissolve sodium alginate to make glue;

[0049] Step c. Defoaming: place the container containing the glue in a water bath, and remove the bubbles by heating to boiling;

[0050] Step d. Glue dipping: Use a metal mold to dip into the glue solution at room temperature. After each mold is even...

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PUM

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Abstract

The present invention discloses the preparation process of botanical hollow enteric capsule. The botanical hollow enteric capsule is prepared with sodium alginate extracted from kelp or Sargasso as material, and through the technological steps of preparing gelatin, preparing sol, debubbling, adhering, converting, purifying, stoving, cutting, etc. It is used in making medicine capsule, and has the advantages of high safety, low cost and no toxic side effect.

Description

technical field [0001] The invention relates to a method for making a hollow capsule, in particular to a method for making a plant-based enteric-coated hollow hard capsule. Background technique [0002] Empty capsule is a kind of drug carrier, which can be used to fill various powdery and granular drugs, especially for powdery and granular drugs with bitter, astringent or irritating taste, after filling with hollow capsules, the bad taste and smell of the drug will be eliminated. Covering, people will not have bad feeling when swallowing the capsule medicament, after the capsule medicament is swallowed by people, it can disintegrate in people's stomach or intestines, release medicine, and achieve the purpose of drug treatment. There are usually two types of hollow capsules. One is stomach-soluble hollow capsules. After the medicines in stomach-soluble hollow capsules enter the stomach of the human body, the capsules disintegrate, the medicines in the capsules are released, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61J3/07
Inventor 黄族和
Owner 黄族和
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