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Diterpene extract of Siegesbeckia, its preparation process and use thereof in phamacy

A technology of extract and diterpene, which is applied in the field of traditional Chinese medicine extract and its extraction, can solve the problems of large adverse reactions and achieve the effects of guaranteed drug efficacy, immune function suppression, and high content of active ingredients

Inactive Publication Date: 2007-05-16
沈斌彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment drugs for this kind of diseases include acetylsalicylic acid, indomethacin, phenylbutazone, clofenac, glucocorticoids, gold preparations, immunosuppressants, etc. Although these drugs have certain therapeutic effects, they have relatively large adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation method I of the extract of the diterpene part of Sisia chinensis

[0032] 3000g of the Chinese herbal medicine, crushed into 20 meshes, added 8 times the amount of 80% ethanol to reflux for extraction for 2 hours, filtered, and the medicinal residues were extracted twice according to the above conditions, the medicinal residues were discarded, the extracts were combined, and recovered to the original state under reduced pressure. 1 / 4 of the volume, put it at low temperature (refrigerated, about 0-4°C) for 12 hours, filter (or centrifuge) the supernatant and concentrate it to dryness under reduced pressure, add 2000ml of 10% methanol aqueous solution, first extract with petroleum ether, each time 600ml for a total of 5 times, recovering petroleum ether, discarding the petroleum ether extract, and then extracting with ethyl acetate, 600ml each time, 5 times in total, and spray drying to obtain the extract of the diterpene part of the present ...

Embodiment 2

[0033] Embodiment 2: the preparation method II of the extract of the diterpene part of Sisia chinensis

[0034] 3000g of the Chinese herbal medicine, crushed into 20 meshes, added 8 times the amount of 80% ethanol to reflux for extraction for 2 hours, filtered, and the medicinal residues were extracted twice according to the above conditions, the medicinal residues were discarded, the extracts were combined, and recovered to the original state under reduced pressure. 1 / 4 of the volume, placed at low temperature (refrigerated, about 0-4°C) for 12 hours, filtered (or centrifuged) and the supernatant recovered to the original 1 / 3 volume under reduced pressure to obtain a concentrated solution (3000ml ), purified with D101 resin, after the extract was added to the resin, it was eluted with 3 column volumes of 10% ethanol, discarded the eluent, and then eluted with 5 column volumes of 70% ethanol, collected the eluent and then reduced Pressure recovery, vacuum or spray drying, ca...

Embodiment 3

[0035] Embodiment 3: capsules

[0036] Prescription a:

[0037] Diterpene Parts Extract of Silica 200g

[0038] 80g pregelatinized starch

[0039] 65% ethanol 14ml

[0040] Crosslinked CMC-Na 12g

[0041] Magnesium Stearate 3g

[0042] Make 1000 capsules

[0043] Prescription b:

[0044] Diterpene Parts Extract of Silica 300g

[0045] Microcrystalline Cellulose 120g

[0046] 60% ethanol 18ml

[0047] Crosslinked CMC-Na 18g

[0048] Micronized silica gel 4g

[0049] Make 1000 capsules

[0050] Preparation:

[0051] (1) The extract from the diterpene part of Sisia chinensis and the microcrystalline cellulose were passed through an 80-mesh sieve and mixed evenly;

[0052] (2) prepare 60% ethanol solution as adhesive;

[0053] (3) Add 60% ethanol, pass through a 20-mesh sieve to granulate, dry at 60°C, and granulate at 20 mesh to obtain dry granules;

[0054] (4) Add the cross-linked CMC-Na and magnesium stearate or micr...

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Abstract

The invention discloses a diterpene position extract of Siegesbeckia orientalis L., wherein the content of diterpene compounds in the extract is at least 40%, the content of kirenol is at least 7%. The invention also provides the process for preparing the extract and its use in preparing medicament for the treatment of rheumatism and rheumatoid diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract and an extracting method thereof, more specifically to a diterpene extract and a preparation method thereof, as well as its application in prevention and treatment of rheumatic and rheumatoid diseases. technical background [0002] Siegesbeckia is an annual herbaceous plant of the genus Siegesbeckia in the Compositae family. It is widely distributed in tropical and temperate regions. There are five species of Siegesbeckia in the world: S. orientalis (S. , hairy stem squid (Sglabrescens), gum squid (S.gummifer), horned squid (S.joullensis). There are the first three in our country, all of which are used for medicinal purposes. [0003] The Chinese Pharmacopoeia stipulates that the traditional Chinese medicine 豨莶 is the dry aerial part of the first three original plants. Xishi is bitter, warm and cold in nature, and enters the three meridians of liver, spleen and kidney; its main effects a...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P37/02A61P19/04A61K127/00
Inventor 金耀章小永
Owner 沈斌彬
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