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Wheat bran total alkyl phenol extract and its preparation method and application

A technology of wheat bran and alkylphenols, which is applied in the field of wheat bran total alkylphenols extract and its preparation process, can solve the problems of pharmacological activity research on the absence of wheat bran alkylphenols, and achieve broadening of comprehensive applications, Guaranteeing safety and reliability, and improving the effect of ascites symptoms

Inactive Publication Date: 2007-04-18
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research on the pharmacological activity of the alkylphenols in wheat bran at home and abroad.

Method used

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  • Wheat bran total alkyl phenol extract and its preparation method and application
  • Wheat bran total alkyl phenol extract and its preparation method and application
  • Wheat bran total alkyl phenol extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Extraction of total alkylphenols from wheat bran

Embodiment 11

[0035] 1. Rinse: Rinse the wheat bran in running water for 4 minutes to remove the flour and sediment, and then drain the remaining water;

[0036] 2. Extraction: Add 8 times the weight of petroleum ether (60-90°C) solvent to wheat bran, heat and reflux at 70°C for extraction, 2 hours / time, 3 times in total. Recover the solvent to obtain the oily components of wheat bran;

[0037] 3. Saponification: the obtained oily components are saponified with 8 times the weight of a 4% potassium hydroxide methanol solution in a mass-volume ratio for 3 hours, and the methanol is recovered to obtain a saponified product;

[0038]4. Extraction: dissolve the saponified material with water, extract 3 times with ethyl acetate, backwash the ethyl acetate layer with water to neutrality, add an appropriate amount of anhydrous sodium sulfate for dehydration, filter, and recover ethyl acetate to obtain the unsaponifiable matter;

[0039] 5. Crude crystals: dissolve the unsaponifiable matter with hot pet...

Embodiment 12

[0043] 1. Rinse: Rinse the wheat bran in running water for 4 minutes to remove the flour and silt, and then drain the remaining water;

[0044] 2. Extraction: Add 8 times the weight of solvent petroleum into the wheat bran, soak and percolate for 3 days, 3 times in total. Recover the solvent to obtain the oily components of wheat bran;

[0045] 3. Saponification: the obtained oily components are saponified with 8 times the weight of 4% potassium hydroxide methanol solution for 3 hours, and methanol is recovered to obtain saponified products;

[0046] 4. Extraction: dissolve the saponified material with water, extract 3 times with ethyl acetate, backwash the ethyl acetate layer with water to neutrality, add an appropriate amount of anhydrous sodium sulfate for dehydration, filter, and recover ethyl acetate to obtain the unsaponifiable matter;

[0047] 5. Coarse crystals: dissolve the unsaponifiable matter with hot petroleum ether, crystallize after cooling, and filter to obtain cru...

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Abstract

The present invention discloses a wheat bran total alkylphenol extract and its preparation method. The alkylphenol compound content is 25%-100% of total weight of said extract. Said invention uses wheat bran as raw material, and adopts organic solvent containing water or containing no water as extraction solvent, and its extraction process includes the following steps: washing; using organic solvent to make extraction; saponification; extracting non-saponified material; using hot petroleum ether to make devitrification; finally, utilizing silica gel column to make purification; refining and recrystallization so as to obtain the invented wheat bran total alkylphenol which can be used as additive of antitumor medicine or food.

Description

1. Technical Field: [0001] The invention relates to a medicinal plant component extract, its preparation process and the pharmacological application of the extract, and belongs to the field of agricultural product processing. Specifically, it is a wheat bran total alkylphenol extract and its preparation process, and the use of the extract as an active ingredient in medicine or food additive in the treatment of cancer. 2. Technical background: [0002] Wheat bran is the seed coat of Triticum aestivum L., a gramineous plant. In the treatment of fever, sore, soup, fire, sore, flutter and congestion. "Compendium of Materia Medica": "Bran is wheat husk, which is of the same sex as floating wheat, and the antiperspirant is inferior to floating wheat, and floating wheat has no meat." The Qing "Compendium of Materia Medica" records that it can disperse blood after being processed with vinegar. It relieves pain, ironing waist and feet, arthralgia due to rheumatism, cold and damp beriberi,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/08C07C37/86C07H15/20C07C37/70A61K31/05A61K36/899A61P35/00A23L1/30A61K131/00A23L33/105
Inventor 姜东冯旭曹卫星
Owner NANJING AGRICULTURAL UNIVERSITY
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