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Oil-in-water type nanometer grassleaved sweetflag oil emulsion oral liquid and its prepn process

A technology of calamus oil and oral emulsion, applied in the field of medicine, can solve the problems of large toxic and side effects of western medicine, and achieve the effects of improving solubility, good light transmittance and delaying the disappearance time.

Inactive Publication Date: 2007-03-21
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, western medicine is mostly used in clinical treatment, but about 20% of them become refractory epilepsy, and the side effects of western medicine are relatively large, so it is necessary to develop new antiepileptic drugs from traditional Chinese medicine in our country

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 1.8g of Tween-80, 0.6g of Span-80, and 0.6g of liquid paraffin, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, add 0.1g of calamus oil directly, and stir fully, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion , continue to drop and constantly stir, when the system suddenly becomes thinner, what produces now is the stable yellow transparent oil-in-water type Shichangpu oil nanoemulsion oral liquid, and its total weight is 10.0g.

Embodiment 2

[0049] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 3.6g of polyoxyethylene hydrogenated castor oil, 0.4g of wheat germ oil, and 0.05g of vitamin E oil, put them into a beaker, and stir them by hand at room temperature of 20°C to mix them evenly. Add and stir until it is completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the system viscosity is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or oily. Water-in-water nanoemulsion, continue to drop and stir constantly, when the system suddenly becomes thinner, what is produced at this time is a stable colorless and transparent oil-in-water type calamus oil nanoemulsion oral liquid, which is said to have a total wei...

Embodiment 3

[0051] Use the oil selected by calculating the HLB value, surfactant, and co-surfactant to draw a pseudo-ternary phase diagram according to the rule of 9:1 to 1:9 to determine the optimal ratio. Accurately weigh 4.5g of polyoxyethylene hydrogenated castor oil and 0.5g of olive oil, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 25°C, add 1.0g of calamus oil directly, and stir until completely dissolved, Then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue Add dropwise and constantly stir, when the system suddenly becomes thinner, what produces now is the stable colorless transparent oil-in-water type Shichangpu oil nanoemulsion oral liquid, claiming that its total weight is 10.0g.

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Abstract

The oil-in-water nanometer grassleaved sweetflag oil emulsion oral liquid consists of surfactant, oil, grassleaved sweetflag oil and distilled water. Its preparation process includes the following steps: weighing surfactant with or without co-surfactant; calculating HLB value and selecting oil phase for reaching emulsifying HLB value near that of the surfactant phase; changing the ratio between the surfactant phase and the oil phase regularly; adding grassleaved sweetflag oil into surfactant through stirring; adding distilled water slowly at 20-25 deg.c to form clear and flowing O / W type nanometer emulsion liquid. The nanometer grassleaved sweetflag oil emulsion preparing process results in raised medicine stability, raised bioavailability, delayed in vivo metabolism time, reduced supplementary material amount, lowered production process and wide medicine market foreground.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical preparation and a preparation method thereof, in particular to a transparent and stable oil-in-water type calamus oil nanoemulsion oral liquid and a preparation method thereof. Background technique [0002] Epilepsy is a common chronic disease of the nervous system. The prevalence rate in my country is 3-7%, and the incidence rate is 5-7%. Epilepsy has the clinical characteristics of repeated seizures and difficult to heal, which causes heavy psychosomatic spasm and mental burden to the patient and the patient's family members. When an attack occurs, it can often be complicated by other injuries, even life-threatening, and has great harm to individuals and society. At present, most of them are treated with western medicine, but about 20% of them still become refractory epilepsy, and the side effects of western medicine are relatively large, so it is necessary to develop ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/107A61P25/08A61P11/06A61P7/02A61P9/10A61K125/00
Inventor 欧阳五庆吴旭锦
Owner NORTHWEST A & F UNIV
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