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Medicinal composition containing human interferon

A composition and interferon technology, applied in the field of medicine, to achieve the effect of being beneficial to use and having less side effects

Inactive Publication Date: 2007-03-14
北京金迪克生物技术有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, α, β, and γ have been studied more and used in clinical treatment; the clinical application value of other types of interferon is still under study

Method used

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  • Medicinal composition containing human interferon
  • Medicinal composition containing human interferon
  • Medicinal composition containing human interferon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] According to the method on pharmaceutics, prepare the spray, the volume of each bottle is 3.65 milliliters, wherein the active content of recombinant human interferon-α2b (Beijing Yuance Pharmaceutical Co., Ltd.) is 3,000,000 IU / ml, and the human albumin content is 0.5 %, the content of benzyl alcohol is 0.5%, the content of polysaccharide is 0.1%, and the concentration of phosphate buffer is 20mmol / L.

[0078] Each bottle of the product in this embodiment is 3 million IU / mL*3.65mL, and one preventive treatment course is 1 bottle, which is used for 3-5 days, which not only ensures the effective dose of interferon for local use, but also limits the dosage.

[0079] Tests were carried out on animals, and its irritation to mucous membranes and skin lesions was similar to that of normal saline, and no serious side effects were found. Compared with the U.S. IntronA powder injection, its side effects were moderate, while the side effects of the product of this example were neg...

Embodiment 2

[0082] According to the preparation method of the injection, add recombinant human interferon-α1a (Beijing Yuance Pharmaceutical Co., Ltd.) to a phosphate buffer solution with a pH of 7, so that the active content of the interferon is 1 million IU / mL, and add benzyl alcohol as a preservative , The weight content is 0.5%.

Embodiment 3

[0084] With reference to the method of Example 2, the obtained injection was divided into vials, 1.5 milliliters per bottle, and freeze-dried to obtain a freeze-dried powder injection.

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Abstract

The invention relates to a medicine compound with interferon. Wherein, said compound can be used to prepare the medicine that prevents and resists virus infection of respiratory tract. Said compound contains interferon and other auxiliary materials. Wherein, said interferon can be alpha2b, alpha1b, beta, Omega, k, lambada, epsilon and other I type; said auxiliary materials contains protector and baffle solution, to realize baffle, stabilize and corrosion-resistant functions.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing human interferon, which belongs to the field of medicine. Background technique: [0002] Interferon (interferons, IFNs) is a class of proteins that have broad-spectrum anti-virus, anti-cell division, immunoregulatory activities and affect cell metabolism, growth and differentiation in different ways at least in the same kind of cells. New synthesis of RNA and protein. It is an important class of cytokines. After nearly 30 years of clinical research and application, it is an important broad-spectrum antiviral and antitumor drug. [0003] type main feature Clinical Applications and Possible Clinical Uses Interferon-α It belongs to type I interferon; there are about 23 variants. There are about 13 subspecies studied in detail Type. Molecular weight of 19-26kDa, composed of 156-166 amino acids. Between 115-151 is a conserved sequence. The gene i...

Claims

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Application Information

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IPC IPC(8): A61K38/21A61K9/08A61K9/12A61K9/19A61P31/12
Inventor 候云德
Owner 北京金迪克生物技术有限责任公司
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