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Method for detecting medical polyethylene glycol

A technology of polyethylene glycol and glass rods, which is applied in thermal analysis of materials, instruments, measuring devices, etc., and can solve problems such as description of crystallization morphology

Active Publication Date: 2007-02-28
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its quality standard refers to "Chinese Pharmacopoeia" (2005 edition), but there is no description of its crystal form under the item of character identification

Method used

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  • Method for detecting medical polyethylene glycol
  • Method for detecting medical polyethylene glycol
  • Method for detecting medical polyethylene glycol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Heat medicinal polyethylene glycol 1500 to 90°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 1500. (see picture 1)

Embodiment 2

[0020] Heat medicinal polyethylene glycol 4000 to 110°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 4000. (See Figure 2)

Embodiment 3

[0022] Heat medicinal polyethylene glycol 6000 to 110°C to melt, dip a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the thickness of the liquid applied on the glass slide can be controlled at 0.02 mm-0.5mm), after cooling and solidifying, place it under an optical microscope to observe the crystal form of pharmaceutical polyethylene glycol 6000. (See Figure 3)

[0023] Fig. 4, Fig. 5 and Fig. 6 show respectively the photo of S-40, poloxamer and stearyl alcohol under the microscope (40 times of magnification); the difference.

[0024] Figure 7 shows that the Qingyan dripping pill with polyethylene glycol as the auxiliary material is heated to 110 ° C to melt, dipped in a small amount of liquid with a glass rod, and spread it thinly on the glass slide heated to the same temperature (the amount of liquid applied on the glass slide The thickness can be controlled at 0.02mm-0.5mm), after cooling and solidificatio...

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Abstract

The invention relates to a method for checking drug carbowax, wherein it comprises: heating carbowax into 90-110Deg. C to be fused; using glass rod to dip some liquid to coat the carrier plate which is heated to same temperature; cooling and solidifying, and arranging it under optical microscope to watch the crystal state of drug carbowax. The watched drug carbowax is radial arranged whose center is crystal core, while the connecting point between three crystals is Y-shape angle, which is the special state of solid carbowax, different with other drop agent. The invention can avoid pretreatment on the drug carbowax.

Description

technical field [0001] The invention relates to an identification method of pharmaceutical auxiliary materials, in particular to an identification method of polyethylene glycol, a commonly used auxiliary material for dropping pills. Background technique [0002] Polyethylene glycol (Macrogol) is a mixture of ethylene oxide and water polycondensation, and its molecular formula is HO(CH 2 CH 2 O) n H represents, wherein n represents the average number of oxyethylene groups. Commonly used solid polyethylene glycols have molecular weights of 1500, 4000, and 6000. Its quality standard refers to "Chinese Pharmacopoeia" (2005 edition), but its crystal form is not described in the item of character identification. Contents of the invention [0003] The purpose of the present invention is to provide a method for identifying medicinal polyethylene glycol. [0004] Technical scheme of the present invention is summarized as follows: [0005] A method for identifying medicinal po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N25/14G01N21/84
Inventor 郭景生王鑫
Owner 津药达仁堂集团股份有限公司第六中药厂
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